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In many real-world applications, it is common that a proportion of the data may be missing or only partially observed. We develop a novel two-sample testing method based on the Maximum Mean Discrepancy (MMD) which accounts for missing data…

统计方法学 · 统计学 2024-05-27 Yijin Zeng , Niall M. Adams , Dean A. Bodenham

Data collected in clinical trials are often composed of multiple types of variables. For example, laboratory measurements and vital signs are longitudinal data of continuous or categorical variables, adverse events may be recurrent events,…

统计方法学 · 统计学 2023-01-12 Tuo Wang , Rachel Zilinskas , Ying Li , Yongming Qu

Covariate shifts are a common problem in predictive modeling on real-world problems. This paper proposes addressing the covariate shift problem by minimizing Maximum Mean Discrepancy (MMD) statistics between the training and test sets in…

机器学习 · 计算机科学 2022-03-03 Liwen Ouyang , Aaron Key

Missing data is a common issue in many biomedical studies. Under a paired design, some subjects may have missing values in either one or both of the conditions due to loss of follow-up, insufficient biological samples, etc. Such partially…

We consider statistical procedures for hypothesis testing of real valued functionals of matched pairs with missing values. In order to improve the accuracy of existing methods, we propose a novel multiplication combination procedure.…

统计理论 · 数学 2018-01-29 Lubna Amro , Frank Konietschke , Markus Pauly

Modeling the dynamics of probability distributions from time-dependent data samples is a fundamental problem in many fields, including digital health. The goal is to analyze how the distribution of a biomarker, such as glucose, changes over…

机器学习 · 统计学 2025-09-18 Antonio Álvarez-López , Marcos Matabuena

Existing two-sample testing techniques, particularly those based on choosing a kernel for the Maximum Mean Discrepancy (MMD), often assume equal sample sizes from the two distributions. Applying these methods in practice can require…

机器学习 · 统计学 2025-12-17 Aaron Wei , Milad Jalali , Danica J. Sutherland

The maximum mean discrepancy (MMD) is a kernel-based nonparametric statistic for two-sample testing, whose inferential accuracy depends critically on variance characterization. Existing work provides various finite-sample estimators of the…

机器学习 · 统计学 2026-02-05 Shijie Zhong , Yikun Yang , Da Gong , Jiangfeng Fu

Several researchers have proposed minimisation of maximum mean discrepancy (MMD) as a method to quantise probability measures, i.e., to approximate a target distribution by a representative point set. We consider sequential algorithms that…

机器学习 · 统计学 2021-02-15 Onur Teymur , Jackson Gorham , Marina Riabiz , Chris. J. Oates

Two-sample hypothesis testing-determining whether two sets of data are drawn from the same distribution-is a fundamental problem in statistics and machine learning with broad scientific applications. In the context of nonparametric testing,…

机器学习 · 统计学 2026-04-21 Antoine Chatalic , Marco Letizia , Nicolas Schreuder , Lorenzo Rosasco

Maximum Mean Discrepancy (MMD) is a widely used concept in machine learning research which has gained popularity in recent years as a highly effective tool for comparing (finite-dimensional) distributions. Since it is designed as a…

机器学习 · 统计学 2025-06-03 Andrew Alden , Blanka Horvath , Zacharia Issa

Detecting changes is of fundamental importance when analyzing data streams and has many applications, e.g., in predictive maintenance, fraud detection, or medicine. A principled approach to detect changes is to compare the distributions of…

机器学习 · 计算机科学 2025-02-13 Florian Kalinke , Marco Heyden , Georg Gntuni , Edouard Fouché , Klemens Böhm

Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…

应用统计 · 统计学 2021-03-30 Marcos Matabuena , Alexander Petersen , Juan C. Vidal , Francisco Gude

Commonly used methods to analyze incomplete longitudinal clinical trial data include complete case analysis (CC) and last observation carried forward (LOCF). However, such methods rest on strong assumptions, including missing completely at…

Gaussian Mixture models (GMMs) are a powerful tool for clustering, classification and density estimation when clustering structures are embedded in the data. The presence of missing values can largely impact the GMMs estimation process,…

机器学习 · 统计学 2020-06-05 Alessio Serafini , Thomas Brendan Murphy , Luca Scrucca

Various statistical tests have been developed for testing the equality of means in matched pairs with missing values. However, most existing methods are commonly based on certain distributional assumptions such as normality, 0-symmetry or…

统计理论 · 数学 2016-03-02 Lubna Amro , Markus Pauly

A new robust pairwise statistic, the pairwise median scaled difference (MSD), is proposed for the detection of anomalous location/uncertainty pairs in heteroscedastic interlaboratory study data with associated uncertainties. The…

应用统计 · 统计学 2018-10-05 Stephen L. R. Ellison

We develop novel clustering algorithms for functional data when the number of clusters $K$ is unknown and also when it is prefixed. These algorithms are developed based on the Maximum Mean Discrepancy (MMD) measure between two sets of…

统计方法学 · 统计学 2025-07-16 Sourav Chakrabarty , Anirvan Chakraborty , Shyamal K. De

We present new results for consistency of maximum likelihood estimators with a focus on multivariate mixed models. Our theory builds on the idea of using subsets of the full data to establish consistency of estimators based on the full…

统计理论 · 数学 2019-02-13 Karl Oskar Ekvall , Galin L. Jones

Modern datasets commonly feature both substantial missingness and many variables of mixed data types, which present significant challenges for estimation and inference. Complete case analysis, which proceeds using only the observations with…

统计方法学 · 统计学 2023-04-10 Joseph Feldman , Daniel R. Kowal
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