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Sorting and separation of microparticles is a challenging problem of interdisciplinary nature. Existing technologies can differentiate microparticles by their bulk properties, such as size, density, electric polarizability, etc. The next…

软凝聚态物质 · 物理学 2018-09-03 Chenhui Peng , Taras Turiv , Yubing Guo , Qi-Huo Wei , Oleg D. Lavrentovich

Phase segregation, the process by which the components of a binary mixture spontaneously separate, is a key process in the evolution and design of many chemical, mechanical, and biological systems. In this work, we present a data-driven…

机器学习 · 计算机科学 2018-03-28 Amir Barati Farimani , Joseph Gomes , Rishi Sharma , Franklin L. Lee , Vijay S. Pande

Molecular packing, crystallinity, and texture of semiconducting polymers are often critical to performance. Although frame-works exist to quantify the ordering, interpretations are often just qualitative, resulting in imprecise and liberal…

软凝聚态物质 · 物理学 2020-05-28 Zhengxing Peng , Long Ye , Harald Ade

Crystallization is a key step in macromolecular structure determination by crystallography. While a robust theoretical treatment of the process is available, due to the complexity of the system, the experimental process is still largely one…

生物大分子 · 定量生物学 2016-08-02 Irem Altan , Patrick Charbonneau , Edward H. Snell

Phase separation is the thermodynamic process that explains how droplets form in multicomponent fluids. These droplets can provide controlled compartments to localize chemical reactions, and reactions can also affect the droplets' dynamics.…

软凝聚态物质 · 物理学 2022-09-02 David Zwicker

Cells control their size to cope with noise during growth and division. Eukaryotic cells exhibiting "sizer" control (targeting a specific size before dividing) may rely on molecular concentration thresholds, but simple implementations of…

生物物理 · 物理学 2026-05-08 Motasem ElGamel , Lucas Ribaudo , Andrew Mugler

Phase separation and transitions among different molecular states are ubiquitous in living cells. Such transitions can be governed by local equilibrium thermodynamics or by active processes controlled by biological fuel. It remains largely…

生物物理 · 物理学 2021-11-24 G. Bartolucci , O. Adame-Arana , X. Zhao , C. A. Weber

Biomolecular condensates form on timescales of seconds in cells upon environmental or compositional changes. Condensate formation is thus argued to act as a mechanism for sensing such changes and quickly initiating downstream processes,…

亚细胞过程 · 定量生物学 2025-12-09 Henry Alston , Mason Rouches , Arvind Murugan , Aleksandra M. Walczak , Thierry Mora

In order to understand the nuclei which develop during the course of protein folding and unfolding, we examine phase segregation of a single heteropolymer chain which occurs in equilibrium. These segregated conformations are characterized…

无序系统与神经网络 · 物理学 2009-10-31 Rose Du , Alexander Yu. Grosberg , Toyoichi Tanaka

Phase separation under non-equilibrium conditions is exploited by biological cells to organize their cytoplasm but remains poorly understood as a physical phenomenon. Here, we study a ternary fluid model in which phase-separating molecules…

软凝聚态物质 · 物理学 2018-02-21 Jean David Wurtz , Chiu Fan Lee

Microcanonical Monte Carlo simulations of a polydisperse soft-spheres model for liquids and colloids have been performed for very large polydispersity, in the region where a phase-separation is known to occur when the system (or part of it)…

软凝聚态物质 · 物理学 2011-08-31 L. A. Fernandez , V. Martin-Mayor , B. Seoane , P. Verrocchio

We study the problem of phase separation in systems with a positive definite order parameter, and in particular, in systems with absorbing states. Owing to the presence of a single minimum in the free energy driving the relaxation kinetics,…

凝聚态物理 · 物理学 2009-10-31 M. A. Munoz , U. Marini Bettolo Marconi , R. Cafiero

Giant unilamellar vesicles (GUVs) composed of as few as three lipid species can phase separate into small-scale lipid domains with stripes and dots patterns. These patterns have been experimentally characterized in terms of how their size…

软凝聚态物质 · 物理学 2025-05-21 Qiwei Yu , Andrej Košmrlj

The formation and dynamics of a wide variety of binary two-dimensional ordered structures and superlattices are investigated through a phase field crystal model with sublattice ordering. Various types of binary ordered phases, the phase…

软凝聚态物质 · 物理学 2019-09-25 Doaa Taha , S. R. Dlamini , S. K. Mkhonta , K. R. Elder , Zhi-Feng Huang

Molecule generation is central to a variety of applications. Current attention has been paid to approaching the generation task as subgraph prediction and assembling. Nevertheless, these methods usually rely on hand-crafted or external…

机器学习 · 计算机科学 2022-12-20 Xiangzhe Kong , Wenbing Huang , Zhixing Tan , Yang Liu

Liquid-liquid phase separation plays a major role in the formation and maintenance of various membrane-less subcellular structures in the cytoplasm and nucleus of cells. Biological condensates contain enhanced concentrations of proteins and…

软凝聚态物质 · 物理学 2023-10-03 Paul C Bressloff

Liposomes that achieve a heterogeneous and spatially organized surface through phase separation have been recognized to be a promising platform for delivery purposes. However, their design and optimization through experimentation can be…

软凝聚态物质 · 物理学 2021-11-05 Y. Wang , Y. Palzhanov , A. Quaini , M. Olshanskii , S. Majd

The smoothing distribution is the conditional distribution of the diffusion process in the space of trajectories given noisy observations made continuously in time. It is generally difficult to sample from this distribution. We use the…

概率论 · 数学 2025-03-07 Oskar Eklund , Annika Lang , Moritz Schauer

The self-organization of proteins into enriched compartments and the formation of complex patterns are crucial processes for life on the cellular level. Liquid-liquid phase separation is one mechanism for forming such enriched compartments.…

软凝聚态物质 · 物理学 2025-04-07 Antonia Winter , Yuhao Liu , Alexander Ziepke , George Dadunashvili , Erwin Frey

Phase separation of a liquid mixture embedded within an elastic network is relevant to a wide range of natural and industrial systems, including biomolecular condensates interacting with the cytoskeleton, structural colouring in bird…

软凝聚态物质 · 物理学 2025-08-14 Oliver W. Paulin , Yicheng Qiang , David Zwicker