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This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

基因组学 · 定量生物学 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer

Current computational methods for exon-intron structure prediction from a cluster of transcript (EST, mRNA) data do not exhibit the time and space efficiency necessary to process large clusters of over than 20,000 ESTs and genes longer than…

基因组学 · 定量生物学 2010-05-11 Paola Bonizzoni , Gianluca Della Vedova , Yuri Pirola , Raffaella Rizzi

We study the Maximum Cardinality Matching (MCM) and the Maximum Weight Matching (MWM) problems, on trees and on some special classes of graphs, in the Online Preemptive and the Incremental Dynamic Graph models. In the {\em Online…

数据结构与算法 · 计算机科学 2018-01-23 Sumedh Tirodkar , Sundar Vishwanathan

The emerging mobile devices in this era of internet-of-things (IoT) require a dedicated processor to enable computationally intensive applications such as neuromorphic computing and signal processing. Vector-by-matrix multiplication (VMM)…

信号处理 · 电气工程与系统科学 2020-01-08 Shubham Sahay , Mohammad Bavandpour , Mohammad Reza Mahmoodi , Dmitri Strukov

Entity resolution (ER) is a fundamental task in data integration that enables insights from heterogeneous data sources. The primary challenge of ER lies in classifying record pairs as matches or nonmatches, which in multi-source ER (MS-ER)…

数据库 · 计算机科学 2026-04-10 Victor Christen , Peter Christen

Tree-based models underpin many modern semantic search engines and recommender systems due to their sub-linear inference times. In industrial applications, these models operate at extreme scales, where every bit of performance is critical.…

机器学习 · 计算机科学 2022-02-25 Philip A. Etter , Kai Zhong , Hsiang-Fu Yu , Lexing Ying , Inderjit Dhillon

Memory plays a key role in enhancing LLMs' performance when deployed to real-world applications. Existing solutions face trade-offs: explicit memory designs based on external storage require complex management and incur storage overhead,…

计算与语言 · 计算机科学 2025-02-25 Xiaoqiang Wang , Suyuchen Wang , Yun Zhu , Bang Liu

In highly repetitive strings, like collections of genomes from the same species, distinct measures of repetition all grow sublinearly in the length of the text, and indexes targeted to such strings typically depend only on one of these…

数据结构与算法 · 计算机科学 2015-02-24 Djamal Belazzougui , Fabio Cunial , Travis Gagie , Nicola Prezza , Mathieu Raffinot

We tackle the problem of multiscale regression for predictors that are spatially or temporally indexed, or with a pre-specified multiscale structure, with a Bayesian modular approach. The regression function at the finest scale is expressed…

统计方法学 · 统计学 2018-09-18 Michele Peruzzi , David B. Dunson

With advances in scientific computing, computer experiments are increasingly used for optimizing complex systems. However, for modern applications, e.g., the optimization of nuclear physics detectors, each experiment run can require…

机器学习 · 统计学 2025-08-08 Hwanwoo Kim , Simon Mak , Ann-Kathrin Schuetz , Alan Poon

Linear mixed models (LMM) are widely adopted in genome-wide association studies (GWAS) to account for population stratification and cryptic relatedness. However, the parameter estimation of LMMs imposes substantial computational burdens due…

统计计算 · 统计学 2025-08-08 Zhibin Pu , Shufei Ge , Shijia Wang

General Matrix Multiplication (GEMM) is a ubiquitous compute kernel in deep learning (DL). To support energy-efficient edge-native processing, new GEMM hardware units have been proposed that operate on unary encoded bitstreams using much…

The advancement of deep learning has led to the emergence of Mixture-of-Experts (MoEs) models, known for their dynamic allocation of computational resources based on input. Despite their promise, MoEs face challenges, particularly in terms…

计算与语言 · 计算机科学 2024-04-09 Alexandre Muzio , Alex Sun , Churan He

Mantaci et al. [TCS 2007] defined the eBWT to extend the definition of the BWT to a collection of strings, however, since this introduction, it has been used more generally to describe any BWT of a collection of strings and the fundamental…

数据结构与算法 · 计算机科学 2021-06-22 Christina Boucher , Davide Cenzato , Zsuzsanna Lipták , Massimiliano Rossi , Marinella Sciortino

Linear exact modeling is a problem coming from system identification: Given a set of observed trajectories, the goal is find a model (usually, a system of partial differential and/or difference equations) that explains the data as precisely…

最优化与控制 · 数学 2011-10-26 Kristina Schindelar , Viktor Levandovskyy , Eva Zerz

We give a new successor data structure which improves upon the index size of the P\v{a}tra\c{s}cu-Thorup data structures, reducing the index size from $O(n w^{4/5})$ bits to $O(n \log w)$ bits, with optimal probe complexity. Alternatively,…

数据结构与算法 · 计算机科学 2013-06-18 Sarel Cohen , Amos Fiat , Moshik Hershcovitch , Haim Kaplan

Unified Virtual Memory (UVM) relieves the developers from the onus of maintaining complex data structures and explicit data migration by enabling on-demand data movement between CPU memory and GPU memory. However, on-demand paging soon…

分布式、并行与集群计算 · 计算机科学 2023-01-11 Xinjian Long , Xiangyang Gong , Huiyang Zhou

Best match graphs (BMGs) are a class of colored digraphs that naturally appear in mathematical phylogenetics and can be approximated with the help of similarity measures between gene sequences, albeit not without errors. The corresponding…

组合数学 · 数学 2021-03-15 David Schaller , Manuela Geiß , Marc Hellmuth , Peter F. Stadler

Nowadays, Large Language Models (LLMs) have been trained using extended context lengths to foster more creative applications. However, long context training poses great challenges considering the constraint of GPU memory. It not only leads…

Data in the form of rankings, ratings, pair comparisons or clicks are frequently collected in diverse fields, from marketing to politics, to understand assessors' individual preferences. Combining such preference data with features…

统计方法学 · 统计学 2024-02-19 Emilie Eliseussen , Arnoldo Frigessi , Valeria Vitelli
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