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Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these…

机器学习 · 计算机科学 2024-01-15 Lingchao Mao , Hairong Wang , Leland S. Hu , Nhan L Tran , Peter D Canoll , Kristin R Swanson , Jing Li

Perturbation experiments allow biologists to discover causal relationships between variables of interest, but the sparsity and high dimensionality of these data pose significant challenges for causal structure learning algorithms.…

定量方法 · 定量生物学 2024-10-21 Peiwen Li , Menghua Wu

Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and…

应用统计 · 统计学 2019-10-04 Irene Y. Chen , Monica Agrawal , Steven Horng , David Sontag

With the advances of data-driven machine learning research, a wide variety of prediction problems have been tackled. It has become critical to explore how machine learning and specifically deep learning methods can be exploited to analyse…

机器学习 · 计算机科学 2021-11-09 David Ahmedt-Aristizabal , Mohammad Ali Armin , Simon Denman , Clinton Fookes , Lars Petersson

While there are a plethora of methods for link prediction in knowledge graphs, state-of-the-art approaches are often black box, obfuscating model reasoning and thereby limiting the ability of users to make informed decisions about model…

机器学习 · 计算机科学 2024-06-05 Niraj Kumar-Singh , Gustavo Polleti , Saee Paliwal , Rachel Hodos-Nkhereanye

Effectively representing medical concepts and patients is important for healthcare analytical applications. Representing medical concepts for healthcare analytical tasks requires incorporating medical domain knowledge and prior information…

机器学习 · 计算机科学 2023-05-02 Shaodong Wang , Qing Li , Wenli Zhang

Image-based characterization and disease understanding involve integrative analysis of morphological, spatial, and topological information across biological scales. The development of graph convolutional networks (GCNs) has created the…

图像与视频处理 · 电气工程与系统科学 2022-04-22 Kexin Ding , Mu Zhou , Zichen Wang , Qiao Liu , Corey W. Arnold , Shaoting Zhang , Dimitri N. Metaxas

Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing…

人工智能 · 计算机科学 2019-03-08 Junyuan Shang , Cao Xiao , Tengfei Ma , Hongyan Li , Jimeng Sun

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

计算与语言 · 计算机科学 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Automatic radiology report generation has been an attracting research problem towards computer-aided diagnosis to alleviate the workload of doctors in recent years. Deep learning techniques for natural image captioning are successfully…

计算机视觉与模式识别 · 计算机科学 2020-02-20 Yixiao Zhang , Xiaosong Wang , Ziyue Xu , Qihang Yu , Alan Yuille , Daguang Xu

Knowledge graph embedding involves learning representations of entities -- the vertices of the graph -- and relations -- the edges of the graph -- such that the resulting representations encode the known factual information represented by…

机器学习 · 计算机科学 2023-03-21 Thomas Gebhart , Jakob Hansen , Paul Schrater

Knowledge graphs (KGs) play a crucial role in many applications, such as question answering, but incompleteness is an urgent issue for their broad application. Much research in knowledge graph completion (KGC) has been performed to resolve…

人工智能 · 计算机科学 2023-01-10 Yinyu Lan , Shizhu He , Kang Liu , Jun Zhao

In applications of graphical models, we typically have more information than just the samples themselves. A prime example is the estimation of brain connectivity networks based on fMRI data, where in addition to the samples themselves, the…

机器学习 · 统计学 2017-04-21 Yunqi Bu , Johannes Lederer

Real data collected from different applications that have additional topological structures and connection information are amenable to be represented as a weighted graph. Considering the node labeling problem, Graph Neural Networks (GNNs)…

社会与信息网络 · 计算机科学 2020-02-06 Xiaoxiao Li , Joao Saude

Automatic radiology report generation is critical in clinics which can relieve experienced radiologists from the heavy workload and remind inexperienced radiologists of misdiagnosis or missed diagnose. Existing approaches mainly formulate…

图像与视频处理 · 电气工程与系统科学 2022-11-08 Shuxin Yang , Xian Wu , Shen Ge , Shaohua Kevin Zhou , Li Xiao

Graph embedding methods aim at finding useful graph representations by mapping nodes to a low-dimensional vector space. It is a task with important downstream applications, such as link prediction, graph reconstruction, data visualization,…

机器学习 · 计算机科学 2022-09-13 Said Kerrache , Hafida Benhidour

Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a…

图像与视频处理 · 电气工程与系统科学 2021-03-11 Songxiao Yang , Xiabi Liu , Zhongshu Zheng , Wei Wang , Xiaohong Ma

The limits of molecular dynamics (MD) simulations of macromolecules are steadily pushed forward by the relentless developments of computer architectures and algorithms. This explosion in the number and extent (in size and time) of MD…

Electronic Medical Records (EMRs), while integral to modern healthcare, present challenges for clinical reasoning and diagnosis due to their complexity and information redundancy. To address this, we proposed medIKAL (Integrating Knowledge…

计算与语言 · 计算机科学 2025-02-18 Mingyi Jia , Junwen Duan , Yan Song , Jianxin Wang

This paper addresses the problems of missing reasoning chains and insufficient entity-level semantic understanding in large language models when dealing with tasks that require structured knowledge. It proposes a fine-tuning algorithm…

计算与语言 · 计算机科学 2025-08-21 Wuyang Zhang , Yexin Tian , Xiandong Meng , Mengjie Wang , Junliang Du