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Because of the rapid spread of COVID-19 to almost every part of the globe, huge volumes of data and case studies have been made available, providing researchers with a unique opportunity to find trends and make discoveries like never…

机器学习 · 计算机科学 2021-10-20 Sarwan Ali , Yijing Zhou , Murray Patterson

Counterfactual inference provides a mathematical framework for reasoning about hypothetical outcomes under alternative interventions, bridging causal reasoning and predictive modeling. We present a counterfactual inference framework for…

机器学习 · 计算机科学 2025-10-22 Jingya Cheng , Alaleh Azhir , Jiazi Tian , Hossein Estiri

The current outbreak of COVID-19 has called renewed attention to the need for sound statistical analysis for monitoring mortality patterns and trends over time. Excess mortality has been suggested as the most appropriate indicator to…

应用统计 · 统计学 2020-10-13 Patrizio Vanella , Ugofilippo Basellini , Berit Lange

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

统计方法学 · 统计学 2018-01-04 Peng Ding , Fan Li

Causal inference is widely used in various fields, such as biology, psychology and economics, etc. In observational studies, we need to balance the covariates before estimating causal effect. This study extends the one-dimensional entropy…

统计方法学 · 统计学 2022-05-19 Juan Chen , Yingchun Zhou

The era of big data has witnessed an increasing availability of multiple data sources for statistical analyses. We consider estimation of causal effects combining big main data with unmeasured confounders and smaller validation data with…

统计方法学 · 统计学 2021-08-24 Shu Yang , Peng Ding

Exposure to air pollution is associated with increased morbidity and mortality. Recent technological advancements permit the collection of time-resolved personal exposure data. Such data are often incomplete with missing observations and…

Comparing counterfactual distributions can provide more nuanced and valuable measures for causal effects, going beyond typical summary statistics such as averages. In this work, we consider characterizing causal effects via distributional…

机器学习 · 统计学 2024-11-05 Kwangho Kim , Jisu Kim , Edward H. Kennedy

Multiple imputation is a highly recommended technique to deal with missing data, but the application to longitudinal datasets can be done in multiple ways. When a new wave of longitudinal data arrives, we can treat the combined data of…

统计方法学 · 统计学 2026-05-18 X. M. Kavelaars , S. van Buuren , J. R. van Ginkel

The analysis of complex longitudinal data such as COVID-19 deaths is challenging due to several inherent features: (i) Similarly-shaped profiles with different decay patterns; (ii) Unexplained variation among repeated measurements within…

Based on recent studies, some COVID-19 symptoms can persist for months after infection, leading to what is termed long COVID. Factors such as vaccination timing, patient characteristics, and symptoms during the acute phase of infection may…

机器学习 · 计算机科学 2025-04-30 Milad Leyli-abadi , Jean-Patrick Brunet , Axel Tahmasebimoradi

When pandemics like COVID-19 spread around the world, the rapidly evolving situation compels officials and executives to take prompt decisions and adapt policies depending on the current state of the disease. In this context, it is crucial…

Standard methods for estimating average causal effects require complete observations of the exposure and confounders. In observational studies, however, missing data are ubiquitous. Motivated by a study on the effect of prescription opioids…

统计方法学 · 统计学 2025-06-30 Lan Wen , Glen McGee

Unmeasured confounding presents a significant challenge in causal inference from observational studies. Classical approaches often rely on collecting proxy variables, such as instrumental variables. However, in applications where the…

统计方法学 · 统计学 2025-01-16 Xiaochuan Shi , Dehan Kong , Linbo Wang

Determinants of COVID-19 clinical severity are commonly assessed by transverse or longitudinal studies of the fatality counts. However, the fatality counts depend both on disease clinical severity and transmissibility, as more infected also…

种群与进化 · 定量生物学 2021-09-02 Sofija Markovic , Andjela Rodic , Igor Salom , Ognjen Milicevic , Magdalena Djordjevic , Marko Djordjevic

This study aims to solve the over-reliance on the rank estimation strategy in the standard tensor factorization-based tensor recovery and the problem of a large computational cost in the standard t-SVD-based tensor recovery. To this end, we…

机器学习 · 计算机科学 2023-05-22 Jingjing Zheng , Wenzhe Wang , Xiaoqin Zhang , Xianta Jiang

Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

机器学习 · 计算机科学 2023-04-18 Omer Noy , Ron Shamir

Understanding and quantifying cause and effect is an important problem in many domains. The generally-agreed solution to this problem is to perform a randomised controlled trial. However, even when randomised controlled trials can be…

机器学习 · 统计学 2023-02-22 Graham Van Goffrier , Lucas Maystre , Ciarán Gilligan-Lee

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

统计方法学 · 统计学 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

We demonstrate a comprehensive semiparametric approach to causal mediation analysis, addressing the complexities inherent in settings with longitudinal and continuous treatments, confounders, and mediators. Our methodology utilizes a…