相关论文: SubOmiEmbed: Self-supervised Representation Learni…

Vision foundation models (FMs) achieve state-of-the-art performance in medical imaging. However, they encode information in abstract latent representations that clinicians cannot interrogate or verify. The goal of this study is to…

Multimodal VAEs seek to model the joint distribution over heterogeneous data (e.g.\ vision, language), whilst also capturing a shared representation across such modalities. Prior work has typically combined information from the modalities…

Self-supervised learning has revolutionized medical imaging by enabling efficient and generalizable feature extraction from large-scale unlabeled datasets. Recently, self-supervised foundation models have been extended to three-dimensional…

Deep generative models are increasingly becoming integral parts of the in silico molecule design pipeline and have dual goals of learning the chemical and structural features that render candidate molecules viable while also being flexible…

The claims data, containing medical codes, services information, and incurred expenditure, can be a good resource for estimating an individual's health condition and medical risk level. In this study, we developed Transformer-based…

Variational auto-encoders (VAEs) have proven to be a well suited tool for performing dimensionality reduction by extracting latent variables lying in a potentially much smaller dimensional space than the data. Their ability to capture…

Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to late diagnosis and extensive heterogeneity across subtypes. Current diagnostic methods are limited in their ability to reveal underlying genomic…

Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet patient responses remain highly variable, and the biological mechanisms underlying resistance are poorly understood. While machine learning models hold promise for…

Supervised manifold learning methods learn data representations by preserving the geometric structure of data while enhancing the separation between data samples from different classes. In this work, we propose a theoretical study of…

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor…

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

This work presents an omics-driven modeling pipeline that integrates machine-learning tools to facilitate the dynamic modeling of multiscale biological systems. Random forests and permutation feature importance are proposed to mine omics…

Multi-label Learning on Image data has been widely exploited with deep learning models. However, supervised training on deep CNN models often cannot discover sufficient discriminative features for classification. As a result, numerous…

We propose a new deep learning method for tumour segmentation when dealing with missing imaging modalities. Instead of producing one network for each possible subset of observed modalities or using arithmetic operations to combine feature…

Multimodal Language Analysis is a demanding area of research, since it is associated with two requirements: combining different modalities and capturing temporal information. During the last years, several works have been proposed in the…

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

The clinical integration of deep learning models for brain tumor diagnosis in neuro-oncology is severely constrained by limited expert-annotated MRI data and substantial inter-institutional domain shift arising from variations in scanners,…

Variational Autoencoder is a scalable method for learning latent variable models of complex data. It employs a clear objective that can be easily optimized. However, it does not explicitly measure the quality of learned representations. We…

Self-supervised learning aims to learn representation that can be effectively generalized to downstream tasks. Many self-supervised approaches regard two views of an image as both the input and the self-supervised signals, assuming that…

Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly hard in an…