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Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities caused by high-dose exposure to critical structures remain a…

Constraint-based causal discovery methods require a large number of conditional independence (CI) tests, which severely limits their practical applicability due to high computational complexity. Therefore, it is crucial to design an…

机器学习 · 计算机科学 2026-02-10 Shunyu Zhao , Yanfeng Yang , Shuai Li , Kenji Fukumizu

Leveraging external or historical data to improve the efficiency of randomized clinical trials without introducing bias or inflating the Type I error rate remains challenging. Recent work on externally trained prognostic scores, such as…

统计方法学 · 统计学 2026-05-28 Junyi Zhou , Qing Liu , May Mo , Amy Xia

Causal inference studies whether the presence of a variable influences an observed outcome. As measured by quantities such as the "average treatment effect," this paradigm is employed across numerous biological fields, from vaccine and drug…

Causal effect estimation from observational data is a crucial but challenging task. Currently, only a limited number of data-driven causal effect estimation methods are available. These methods either provide only a bound estimation of the…

统计方法学 · 统计学 2020-11-10 Debo Cheng , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Lee , Jixue Liu

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

统计方法学 · 统计学 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau

We address the problem of two-variable causal inference without intervention. This task is to infer an existing causal relation between two random variables, i.e. $X \rightarrow Y$ or $Y \rightarrow X$ , from purely observational data. As…

机器学习 · 统计学 2020-01-07 Maximilian Kurthen , Torsten A. Enßlin

We intend to create a new risk assessment methodology that combines the best characteristics of both risk score and machine learning models. More specifically, we aim to develop a method that, besides having a good performance, offers a…

机器学习 · 计算机科学 2021-10-19 Francisco Valente , Jorge Henriques , Simão Paredes , Teresa Rocha , Paulo de Carvalho , João Morais

Purpose: This study presents a Deep Learning (DL)-based quality assessment (QA) approach for evaluating auto-generated contours (auto-contours) in radiotherapy, with emphasis on Online Adaptive Radiotherapy (OART). Leveraging Bayesian…

计算机视觉与模式识别 · 计算机科学 2025-05-13 Biling Wang , Austen Maniscalco , Ti Bai , Siqiu Wang , Michael Dohopolski , Mu-Han Lin , Chenyang Shen , Dan Nguyen , Junzhou Huang , Steve Jiang , Xinlei Wang

Conditional independence (CI) testing is a fundamental task in modern statistics and machine learning. The conditional randomization test (CRT) was recently introduced to test whether two random variables, $X$ and $Y$, are conditionally…

机器学习 · 统计学 2024-12-19 Yanfeng Yang , Shuai Li , Yingjie Zhang , Zhuoran Sun , Hai Shu , Ziqi Chen , Renming Zhang

Although the widespread use of AI systems in today's world is growing, many current AI systems are found vulnerable due to hidden bias and missing information, especially in the most commonly used forecasting system. In this work, we…

机器学习 · 计算机科学 2024-07-30 Zhixuan Chu , Hui Ding , Guang Zeng , Shiyu Wang , Yiming Li

Recent methodological developments have introduced new black-box approaches to better estimate heterogeneous treatment effects; however, these methods fall short of providing interpretable characterizations of the underlying individuals who…

统计方法学 · 统计学 2025-08-19 Melody Huang , Tiffany M. Tang , Ana M. Kenney

Causal discovery is a powerful technique for identifying causal relationships among variables in data. It has been widely used in various applications in software engineering. Causal discovery extensively involves conditional independence…

软件工程 · 计算机科学 2023-09-12 Pingchuan Ma , Zhenlan Ji , Peisen Yao , Shuai Wang , Kui Ren

Collaborative causal inference (CCI) is a federated learning method for pooling data from multiple, often self-interested, parties, to achieve a common learning goal over causal structures, e.g. estimation and optimization of treatment…

机器学习 · 计算机科学 2024-07-17 Björn Filter , Ralf Möller , Özgür Lütfü Özçep

Explanatory studies, such as randomized controlled trials, are targeted to extract the true causal effect of interventions on outcomes and are by design adjusted for covariates through randomization. On the contrary, observational studies…

统计方法学 · 统计学 2022-05-02 Riddhiman Adib , Sheikh Iqbal Ahamed , Mohammad Adibuzzaman

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

机器学习 · 计算机科学 2023-04-26 Payam Dibaeinia , Saurabh Sinha

Without a control group, the most widespread methodologies for estimating causal effects cannot be applied. To fill this gap, we propose the Machine Learning Control Method, a new approach for causal panel analysis that estimates causal…

计量经济学 · 经济学 2024-10-28 Augusto Cerqua , Marco Letta , Fiammetta Menchetti

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing…

统计方法学 · 统计学 2020-02-10 Liuyi Yao , Zhixuan Chu , Sheng Li , Yaliang Li , Jing Gao , Aidong Zhang

We aim to generalize the results of a randomized controlled trial (RCT) to a target population with the help of some observational data. This is a problem of causal effect identification with multiple data sources. Challenges arise when the…

统计方法学 · 统计学 2022-06-15 Juha Karvanen

Every day, poison control centers (PCC) are called for immediate classification and treatment recommendations if an acute intoxication is suspected. Due to the time-sensitive nature of these cases, doctors are required to propose a correct…