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Background: Spatial transcriptomics have emerged as a powerful tool in biomedical research because of its ability to capture both the spatial contexts and abundance of the complete RNA transcript profile in organs of interest. However,…

基因组学 · 定量生物学 2025-04-18 Shuo Shuo Liu , Shikun Wang , Yuxuan Chen , Anil K. Rustgi , Ming Yuan , Jianhua Hu

Sepsis is a life-threatening condition which requires rapid diagnosis and treatment. Traditional microbiological methods are time-consuming and expensive. In response to these challenges, deep learning algorithms were developed to identify…

Current metagenome assemblers developed for short sequence reads or noisy long readswere not optimized for accurate long reads. Here we describe hifiasm-meta, a new metagenome assembler that exploits the high accuracy of recent data.…

基因组学 · 定量生物学 2021-10-19 Xiaowen Feng , Haoyu Cheng , Daniel Portik , Heng Li

We study Transformers on the task \emph{program trace generation} (PTG), where models produce step-by-step execution traces for synthetic programs. Unlike existing algorithmic problems, PTG externalizes reasoning through long traces where…

计算与语言 · 计算机科学 2025-09-30 Simeng Sun

Transformer-based architectures have advanced medical image analysis by effectively modeling long-range dependencies, yet they often struggle in 3D settings due to substantial memory overhead and insufficient capture of fine-grained local…

While model architectures and training strategies have become more generic and flexible with respect to different data modalities over the past years, a persistent limitation lies in the assumption of fixed quantities and arrangements of…

图像与视频处理 · 电气工程与系统科学 2023-11-07 Lisa Weijler , Florian Kowarsch , Michael Reiter , Pedro Hermosilla , Margarita Maurer-Granofszky , Michael Dworzak

The remarkable growth and significant success of machine learning have expanded its applications into programming languages and program analysis. However, a key challenge in adopting the latest machine learning methods is the representation…

编程语言 · 计算机科学 2023-12-01 Ali TehraniJamsaz , Quazi Ishtiaque Mahmud , Le Chen , Nesreen K. Ahmed , Ali Jannesari

Interpreting gene clusters from RNA sequencing (RNA-seq) remains challenging, especially in antimicrobial resistance studies where mechanistic insight is important for hypothesis generation. Existing pathway enrichment methods can summarize…

定量方法 · 定量生物学 2026-04-03 Elias Hossain , Mehrdad Shoeibi , Ivan Garibay , Niloofar Yousefi

Reasoning over Temporal Knowledge Graphs (TKGs) aims to predict future facts based on given history. One of the key challenges for prediction is to learn the evolution of facts. Most existing works focus on exploring evolutionary…

人工智能 · 计算机科学 2023-02-03 Yuwei Xia , Mengqi Zhang , Qiang Liu , Shu Wu , Xiao-Yu Zhang

Phylogenetic placement refers to a family of tools and methods to analyze, visualize, and interpret the tsunami of metagenomic sequencing data generated by high-throughput sequencing. Compared to alternative (e. g., similarity-based)…

种群与进化 · 定量生物学 2025-01-09 Lucas Czech , Alexandros Stamatakis , Micah Dunthorn , Pierre Barbera

We have recently witnessed tremendous success of Machine Learning (ML) in practical applications. Computer vision, speech recognition and language translation have all seen a near human level performance. We expect, in the near future, most…

Dynamic graph embedding has emerged as a very effective technique for addressing diverse temporal graph analytic tasks (i.e., link prediction, node classification, recommender systems, anomaly detection, and graph generation) in various…

机器学习 · 计算机科学 2023-12-27 Alan John Varghese , Aniruddha Bora , Mengjia Xu , George Em Karniadakis

We show that Transformer encoder architectures can be sped up, with limited accuracy costs, by replacing the self-attention sublayers with simple linear transformations that "mix" input tokens. These linear mixers, along with standard…

计算与语言 · 计算机科学 2022-05-30 James Lee-Thorp , Joshua Ainslie , Ilya Eckstein , Santiago Ontanon

Finding an interpretable non-redundant representation of real-world data is one of the key problems in Machine Learning. Biological neural networks are known to solve this problem quite well in unsupervised manner, yet unsupervised…

机器学习 · 计算机科学 2020-10-13 Denis Kuzminykh , Laida Kushnareva , Timofey Grigoryev , Alexander Zatolokin

The Transformer architecture has demonstrated a superior ability compared to recurrent neural networks in many different natural language processing applications. Therefore, our study applies a modified Transformer in a speech enhancement…

Catching and attributing code change-induced performance regressions in production is hard; predicting them beforehand, even harder. A primer on automatically learning to predict performance regressions in software, this article gives an…

软件工程 · 计算机科学 2023-05-23 Moritz Beller , Hongyu Li , Vivek Nair , Vijayaraghavan Murali , Imad Ahmad , Jürgen Cito , Drew Carlson , Ari Aye , Wes Dyer

Gait recognition has emerged as a powerful tool for unobtrusive and long-range identity analysis, with growing relevance in surveillance and monitoring applications. Although recent advances in deep learning and large-scale datasets have…

计算机视觉与模式识别 · 计算机科学 2025-05-06 Nicoleta Basoc , Adrian Cosma , Andy Cǎtrunǎ , Emilian Rǎdoi

Temporal Knowledge Graph (TKG) reasoning often involves completing missing factual elements along the timeline. Although existing methods can learn good embeddings for each factual element in quadruples by integrating temporal information,…

人工智能 · 计算机科学 2024-05-02 Zhiyu Fang , Shuai-Long Lei , Xiaobin Zhu , Chun Yang , Shi-Xue Zhang , Xu-Cheng Yin , Jingyan Qin

Metaproteomics has become a crucial omics technology for studying microbiomes. In this area, the Unipept ecosystem, accessible at https://unipept.ugent.be, has emerged as an invaluable resource for analyzing metaproteomic data. It offers…

Transformers are powerful text representation learners, useful for all kinds of clinical decision support tasks. Although they outperform baselines on readmission prediction, they are not infallible. Here, we look into one such failure…

计算与语言 · 计算机科学 2022-08-25 Augusto Garcia-Agundez , Carsten Eickhoff
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