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Two crucial factors for accurate numerical simulations of cardiac electromechanics, which are also essential to reproduce the synchronous activity of the heart, are: i) accounting for the interaction between the heart and the circulatory…

In this paper, we develop a general framework for multicontinuum homogenization in perforated domains. The simulations of problems in perforated domains are expensive and, in many applications, coarse-grid macroscopic models are developed.…

数值分析 · 数学 2024-04-29 Wei Xie , Yalchin Efendiev , Yunqing Huang , Wing Tat Leung , Yin Yang

The focus of our work is dispersive, second-order effective model describing the low-frequency wave motion in heterogeneous (e.g.~functionally-graded) media endowed with periodic microstructure. For this class of quasi-periodic medium…

数值分析 · 数学 2020-06-05 Danial P. Shahraki , Bojan B. Guzina

In this paper, we present the derivation of a multicontinuum model for the coupled flow and transport equations by applying multicontinuum homogenization. We perform the multicontinuum expansion for both flow and transport solutions and…

数值分析 · 数学 2024-05-24 Dmitry Ammosov , W. T. Leung , Buzheng Shan , Jian Huang

We develop a mesoscopic lattice model to study the morphology formation in interacting ternary mixtures with evaporation of one component. As concrete application of our model, we wish to capture morphologies as they are typically arising…

Digestion in the small intestine is the result of complex mechanical and biological phenomena which can be modelled at different scales. In a previous article, we introduced a system of ordinary differential equations for describing the…

偏微分方程分析 · 数学 2011-09-12 Masoomeh Taghipoor , Guy Barles , Christine Georgelin , Jean-René Licois , Philippe Lescoat

Learning neural operators on heterogeneous and irregular geometries remains a fundamental challenge, as existing approaches typically rely on structured discretisations or explicit mappings to a shared reference domain. We propose a unified…

The motion of a eukaryotic cell presents a variety of interesting and challenging problems from both a modeling and a computational perspective. The processes span many spatial scales (from molecular to tissue) as well as disparate time…

细胞行为 · 定量生物学 2010-11-25 Ben Vanderlei , James J. Feng , Leah Edelstein-Keshet

A molecular model is proposed of a bilayer consisting of fully saturated DPPC and mono unsaturated DOPC. The model not only encompasses the constant density within the hydrophobic core of the bilayer, but also the tendency of chain segments…

生物物理 · 物理学 2009-11-10 R. Elliott , K. Katsov , M. Schick , I. Szleifer

A mean-field density-functional model for three-phase equilibria in fluids (or other soft condensed matter) with two spatially varying densities is analyzed analytically and numerically. The interfacial tension between any two out of three…

统计力学 · 物理学 2019-08-14 Kenichiro Koga , Joseph O. Indekeu

A non-local dynamic homogenization technique for the analysis of a viscoelastic heterogeneous material which displays a periodic microstructure is herein proposed. The asymptotic expansion of the micro-displacement field in the transformed…

应用物理 · 物理学 2018-11-26 Rosaria Del Toro , Andrea Bacigalupo , Marco Paggi

The paper is concerned with the derivation and analysis of nonoverlapping domain decomposition for heterogeneous, anisotropic diffusion problems discretized by the finite element cell-centered (FECC) scheme. Differently from the standard…

数值分析 · 数学 2019-05-24 Thanh Hai Ong , Duc Cam Hai Vo , Thi-Thao-Phuong Hoang

We propose a multiscale approach for an elliptic multiscale setting with general unstructured diffusion coefficients that is able to achieve high-order convergence rates with respect to the mesh parameter and the polynomial degree. The…

数值分析 · 数学 2020-09-03 Roland Maier

Modeling contact mechanics with high contrast coefficients presents significant mathematical and computational challenges, especially in achieving strongly symmetric stress approximations for mixed formulations. Due to the inherent…

数值分析 · 数学 2026-02-17 Eric T. Chung , Hyea Hyun Kim , Xiang Zhong

We present a new algorithm to design lightweight cellular materials with required properties in a multi-physics context. In particular, we focus on a thermo-mechanical setting, by promoting the design of unit cells characterized both by an…

计算工程、金融与科学 · 计算机科学 2022-02-21 Matteo Gavazzoni , Nicola Ferro , Simona Perotto , Stefano Foletti

In this paper we establish a homogenization result for a doubly nonlinear parabolic system arising from the hygro-thermo-chemical processes in porous media taking into account memory phenomena. We present a meso-scale model of the composite…

偏微分方程分析 · 数学 2020-01-08 Michal Beneš , Igor Pažanin

Multiphase field models have emerged as an important computational tool for understanding biological tissue while resolving single-cell properties. While they have successfully reproduced many experimentally observed behaviors of living…

软凝聚态物质 · 物理学 2025-02-13 Michael Chiang , Austin Hopkins , Benjamin Loewe , Davide Marenduzzo , M. Cristina Marchetti

We explore the homogenization limit and rigorously derive upscaled equations for a microscopic reaction-diffusion system modeling sulfate corrosion in sewer pipes made of concrete. The system, defined in a periodically-perforated domain, is…

偏微分方程分析 · 数学 2010-11-29 Tasnim Fatima , Adrian Muntean

Unstructured proteins can modulate cellular responses to environmental conditions by undergoing coil-globule transitions and phase separation. However, the molecular mechanisms of these phenomena still need to be fully understood. Here, we…

软凝聚态物质 · 物理学 2023-06-28 Bernat Durà Faulí , Valentino Bianco , Giancarlo Franzese

We present results of numerical self-consistent field (SCF) calculations for the equilibrium mechanical unfolding of a globule formed by a single flexible polymer chain collapsed in a poor solvent. In accordance with earlier scaling theory…