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Electronic health records (EHRs) have become the foundation of machine learning applications in healthcare, while the utility of real patient records is often limited by privacy and security concerns. Synthetic EHR generation provides an…

人工智能 · 计算机科学 2023-12-25 Hongda Sun , Hongzhan Lin , Rui Yan

Motivated by the Acute Respiratory Distress Syndrome Network (ARDSNetwork) ARDS respiratory management (ARMA) trial, we developed a flexible Bayesian machine learning approach to estimate the average causal effect and heterogeneous causal…

应用统计 · 统计学 2024-10-29 Xinyuan Chen , Michael O. Harhay , Guangyu Tong , Fan Li

We propose a novel Bayesian model selection technique on linear mixed-effects models to compare multiple treatments with a control. A fully Bayesian approach is implemented to estimate the marginal inclusion probabilities that provide a…

应用统计 · 统计学 2015-09-28 Lei Gong , James M. Flegal , Stephen R. Spindler , Patricia L. Mote

To address an emerging need for large number of diverse datasets for rigor evaluation of signal processing techniques, we developed and evaluated a new method for generating synthetic electrogastrogram time series. We used…

信号处理 · 电气工程与系统科学 2024-05-09 Nadica Miljković , Nikola Milenić , Nenad B. Popović , Jaka Sodnik

The generation of synthetic medical records using Generative Adversarial Networks (GANs) is becoming crucial for addressing privacy concerns and facilitating data sharing in the medical domain. In this paper, we introduce a novel method to…

图像与视频处理 · 电气工程与系统科学 2023-09-20 Tomohiro Kikuchi , Shouhei Hanaoka , Takahiro Nakao , Tomomi Takenaga , Yukihiro Nomura , Harushi Mori , Takeharu Yoshikawa

Datasets containing large samples of time-to-event data arising from several small heterogeneous groups are commonly encountered in statistics. This presents problems as they cannot be pooled directly due to their heterogeneity or analyzed…

机器学习 · 统计学 2016-12-05 Alexandre Piché , Russell Steele , Ian Shrier , Stephanie Long

Complementary features of randomized controlled trials (RCTs) and observational studies (OSs) can be used jointly to estimate the average treatment effect of a target population. We propose a calibration weighting estimator that enforces…

统计方法学 · 统计学 2022-02-16 Dasom Lee , Shu Yang , Lin Dong , Xiaofei Wang , Donglin Zeng , Jianwen Cai

Traditional epidemic detection algorithms make decisions using only local information. We propose a novel approach that explicitly models spatial information fusion from several metapopulations. Our method also takes into account…

统计计算 · 统计学 2015-09-15 Michael Ludkovski , Katherine Shatskikh

Access to high-quality medical data is often restricted due to privacy concerns, posing significant challenges for training artificial intelligence (AI) algorithms within Electronic Health Record (EHR) applications. In this study, prompt…

人工智能 · 计算机科学 2025-04-30 Polycarp Nalela

Randomized controlled trials (RCTs) are the standard for evaluating the effectiveness of clinical interventions. To address the limitations of RCTs on real-world populations, we developed a methodology that uses a large observational…

机器学习 · 计算机科学 2024-10-21 Panayiotis Petousis , David Gordon , Susanne B. Nicholas , Alex A. T. Bui

With the increasing availability of electronic health records (EHR) linked with biobank data for translational research, a critical step in realizing its potential is to accurately classify phenotypes for patients. Existing approaches to…

统计方法学 · 统计学 2024-04-02 Molei Liu , Xinyi Wang , Chuan Hong

We propose a new statistical approach to obtain differential gene expression of non-detects in quantitative real-time PCR (qPCR) experiments through Bayesian hierarchical modeling. We propose to treat non-detects as non-random missing data,…

应用统计 · 统计学 2019-10-31 Valeriia Sherina , Matthew N. McCall , Tanzy M. T. Love

In electronic health records (EHRs), latent subgroups of patients may exhibit distinctive patterning in their longitudinal health trajectories. For such data, growth mixture models (GMMs) enable classifying patients into different latent…

统计方法学 · 统计学 2022-01-12 Rebecca Anthopolos , Ying Wei , Qixuan Chen

Throughout the different phases of a drug development program, randomized trials are used to establish the tolerability, safety, and efficacy of a candidate drug. At each stage one aims to optimize the design of future studies by…

应用统计 · 统计学 2021-02-08 Sebastian Weber , Andrew Gelman , Daniel Lee , Michael Betancourt , Aki Vehtari , Amy Racine

This paper investigates the use of synthetic face data to enhance Single-Morphing Attack Detection (S-MAD), addressing the limitations of availability of large-scale datasets of bona fide images due to privacy concerns. Various morphing…

计算机视觉与模式识别 · 计算机科学 2025-10-14 David Benavente-Rios , Juan Ruiz Rodriguez , Gustavo Gatica

This paper extends the literature on the theoretical properties of synthetic controls to the case of non-linear generative models, showing that the synthetic control estimator is generally biased in such settings. I derive a lower bound for…

计量经济学 · 经济学 2021-11-23 Oscar Engelbrektson

Pragmatic trials increasingly define outcomes using real-world data such as electronic health records, where assessments are collected during routine care rather than at fixed timepoints. Consequently, these uncontrolled assessments may be…

We present a new procedure for quantum state reconstruction based on weak continuous measurement of an ensemble average. By applying controlled evolution to the initial state new information is continually mapped onto the measured…

量子物理 · 物理学 2009-11-10 Andrew Silberfarb , Poul S. Jessen , Ivan H. Deutsch

Randomized controlled trials play an important role in how Internet companies predict the impact of policy decisions and product changes. In these `digital experiments', different units (people, devices, products) respond differently to the…

应用统计 · 统计学 2015-12-21 Matt Taddy , Matt Gardner , Liyun Chen , David Draper

This paper proposes a new method for in vivo and almost real-time identification of biomechanical properties of the human cornea based on non-contact tonometer data. Further goal is to demonstrate the method's functionality based on…

计算工程、金融与科学 · 计算机科学 2021-07-20 Stefan Muench , Mike Roellig , Daniel Balzani