相关论文: The Computational Drug Repositioning without Negat…

As deep neural networks include a high number of parameters and operations, it can be a challenge to implement these models on devices with limited computational resources. Despite the development of novel pruning methods toward…

We consider the problem of image classification for the purpose of aiding doctors in dermatological diagnosis. Dermatological diagnosis poses two major challenges for standard off-the-shelf techniques: First, the data distribution is…

Crossp-roject defect prediction (CPDP), where data from different software projects are used to predict defects, has been proposed as a way to provide data for software projects that lack historical data. Evaluations of CPDP models using…

The computational underpinnings of positive psychotic symptoms have recently received significant attention. Candidate mechanisms include some combination of maladaptive priors and reduced updating of these priors during perception. A…

Domain adaptive image retrieval includes single-domain retrieval and cross-domain retrieval. Most of the existing image retrieval methods only focus on single-domain retrieval, which assumes that the distributions of retrieval databases and…

In pharmaceutical R&D, predicting the efficacy of a pharmaceutical in treating a particular disease prior to clinical testing or any real-world use has been challenging. In this paper, we propose a flexible and modular machine…

Positive-unlabeled (PU) learning addresses binary classification when only a set of labeled positives is available alongside a pool of unlabeled samples drawn from a mixture of positives and negatives. Existing PU methods typically require…

There has been a flurry of activity around using pretrained diffusion models as informed data priors for solving inverse problems, and more generally around steering these models using reward models. Training-free methods like diffusion…

Computational mental health research develops models to predict and understand psychological phenomena, but often relies on inappropriate measures of psychopathology constructs, undermining validity. We identify three key issues: (1)…

Introduction: Computational modeling has rapidly advanced over the last decades, especially to predict molecular properties for chemistry, material science and drug design. Recently, machine learning techniques have emerged as a powerful…

Maximizing the area under the receiver operating characteristic curve (AUC) is a standard approach to imbalanced classification. So far, various supervised AUC optimization methods have been developed and they are also extended to…

This research addresses the challenge of conducting interpretable causal inference between a binary treatment and its resulting outcome when not all confounders are known. Confounders are factors that have an influence on both the treatment…

Drug repositioning offers an effective solution to drug discovery, saving both time and resources by finding new indications for existing drugs. Typically, a drug takes effect via its protein targets in the cell. As a result, it is…

We propose a new method of learning from positive and unlabeled (PU) examples in highly imbalanced datasets. Many real-world problems, such as disease gene identification, targeted marketing, fraud detection, and recommender systems, are…

Bringing a novel drug from the original idea to market typically requires more than ten years and billions of dollars. To alleviate the heavy burden, a natural idea is to reuse the approved drug to treat new diseases. The process is also…

We propose a meta-learning method for positive and unlabeled (PU) classification, which improves the performance of binary classifiers obtained from only PU data in unseen target tasks. PU learning is an important problem since PU data…

Popularity bias is a persistent issue associated with recommendation systems, posing challenges to both fairness and efficiency. Existing literature widely acknowledges that reducing popularity bias often requires sacrificing recommendation…

Recommender systems often rely on observational user--item interaction data, which is prone to selection bias due to users' selective interactions with items. Inverse propensity weighting and doubly robust estimators effectively mitigate…

Positive Unlabeled (PU) learning aims to learn a binary classifier from only positive and unlabeled data, which is utilized in many real-world scenarios. However, existing PU learning algorithms cannot deal with the real-world challenge in…

We propose a supervised machine learning approach for boosting existing signal and image recovery methods and demonstrate its efficacy on example of image reconstruction in computed tomography. Our technique is based on a local nonlinear…