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Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

应用物理 · 物理学 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Centuries of effort to improve imaging has focused on perfecting and combining lenses to obtain better optical performance and new functionalities. The arrival of nanotechnology has brought to this effort engineered surfaces called…

Nanophotonic structures have versatile applications including solar cells, anti-reflective coatings, electromagnetic interference shielding, optical filters, and light emitting diodes. To design and understand these nanophotonic structures,…

机器学习 · 计算机科学 2023-10-31 Jungtaek Kim , Mingxuan Li , Oliver Hinder , Paul W. Leu

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

基因组学 · 定量生物学 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

Recently, deep learning approaches have become the main research frontier for biological image reconstruction and enhancement problems thanks to their high performance, along with their ultra-fast inference times. However, due to the…

图像与视频处理 · 电气工程与系统科学 2022-03-18 Mehmet Akçakaya , Burhaneddin Yaman , Hyungjin Chung , Jong Chul Ye

Using light to control the movement of nano-structured objects is a great challenge. This challenge involves fields like optical tweezing, Casimir forces, integrated optics, bio-physics, and many others. Photonic "robots" could have…

光学 · 物理学 2015-07-24 Silvia Gentilini , Claudio Conti

Space exemplifies the ultimate test-bed environment for any materials technology. The harsh conditions of space, with extreme temperature changes, lack of gravity and atmosphere, intense solar and cosmic radiation, and mechanical stresses…

科普物理 · 物理学 2020-10-08 Ognjen Ilic

In computational imaging, hardware for signal sampling and software for object reconstruction are designed in tandem for improved capability. Examples of such systems include computed tomography (CT), magnetic resonance imaging (MRI), and…

图像与视频处理 · 电气工程与系统科学 2022-11-01 Andrew Olsen , Yolanda Hu , Vidya Ganapati

Transparent tissue scaffolds enable illumination of growing tissue to accelerate cell proliferation and improve other cell functions through photobiomodulation. The biphasic dose response of cells exposed to photobiomodulating light…

Surface plasmon resonances of metallic nanostructures offer great opportunities to guide and manipulate light on the nanoscale. In the design of novel plasmonic devices, a central topic is to clarify the intricate relationship between the…

光学 · 物理学 2019-09-11 Sanghyeon Yu , Habib Ammari

Confining light illumination in the three dimensions of space is a challenge for various applications. Among these, optogenetic methods developed for live experiments in cell biology would benefit from such a localized illumination as it…

Optical coherence tomography (OCT) is widely used for diagnosing and monitoring retinal diseases, such as age-related macular degeneration (AMD). The segmentation of biomarkers such as layers and lesions is essential for patient diagnosis…

计算机视觉与模式识别 · 计算机科学 2025-09-26 Botond Fazekas , Guilherme Aresta , Philipp Seeböck , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunović

X-ray Computed Tomography (X-ray CT) is a well-known non-destructive imaging technique where contrast originates from the materials' absorption coefficients. Novel battery characterization studies on increasingly challenging samples have…

Optical tomography has emerged as a non-invasive imaging method, providing three-dimensional insights into subcellular structures and thereby enabling a deeper understanding of cellular functions, interactions, and processes. Conventional…

医学物理 · 物理学 2023-12-14 Jiawei Sun , Bin Yang , Nektarios Koukourakis , Jochen Guck , Juergen W. Czarske

Advanced photonic nanostructures have enabled the maximization of synthetic chiroptic activities. The unique structuring of these building blocks has empowered chiral selective interactions with electromagnetic waves in plasmonic structures…

Unprecedented material compatibility and ease of integration, in addition to the unique and diverse optoelectronic properties of layered materials have generated significant interest in their utilization in nanophotonic devices. While…

光学 · 物理学 2018-06-12 Taylor Fryett , Alan Zhan , Arka Majumdar

FRET-based approaches are a unique tool for sensing the immediate surroundings and interactions of (bio)molecules. FRET imaging and FLIM (Fluorescence Lifetime Imaging Microscopy) enable the visualization of the spatial distribution of…

A number of questions in systems biology such as understanding how dynamics of neuronal networks are related to brain function require the ability to capture the functional dynamics of large cellular populations at high speed. Recently,…

Significance: Superconducting nanowire single-photon detectors (SNSPDs; also known as SSPDs) show enormous promise for low-light biomedical imaging by offering exceptional sensitivity, picosecond timing resolution, and broad spectral…

光学 · 物理学 2025-12-09 Emi Cora Valmai Hughes , Avinash Upadhya , Kishan Dholakia

Faithful manipulation of shape, material, and illumination in 2D Internet images would greatly benefit from a reliable factorization of appearance into material (i.e., diffuse and specular) and illumination (i.e., environment maps). On the…

图形学 · 计算机科学 2017-11-15 Tuanfeng Y. Wang , Tobias Ritschel , Niloy J. Mitra
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