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More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at an incredible pace due to recent advances in high-throughput sequencing technologies,…

The development of highly sensitive and rapid biosensing tools targeted to the highly contagious virus SARS-CoV-2 is critical to tackling the COVID-19 pandemic. Quantum sensors can play an important role, thanks to their superior…

量子物理 · 物理学 2022-01-25 Changhao Li , Rouhollah Soleyman , Mohammad Kohandel , Paola Cappellaro

COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in…

Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) caused the ongoing pandemic. This pandemic devastated the world by killing more than a million people, as of October 2020. It is imperative to understand the transmission dynamics…

生物物理 · 物理学 2021-03-24 Caglar Koca , Meltem Civas , Selin M. Sahin , Onder Ergonul , Ozgur B. Akan

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth…

The COVID-19 pandemic is spreading rapidly around the world, causing countries to impose lockdowns and efforts to develop vaccines on a global scale. However, human-to-animal and animal-to-human transmission cannot be ignored, as severe…

种群与进化 · 定量生物学 2024-08-20 Zi Hian Tan , Kian Yan Yong , Jian-Jun Shu

Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target [1-3]. The binding of the spike protein with the ACE2 receptor (ACE2) of the…

生物物理 · 物理学 2021-11-17 Claudia R. Arbeitman , Pablo Rojas , Pedro Ojeda-May , Martin E. Garcia

The deadly coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gone out of control globally. Despite much effort by scientists, medical experts, and society in general, the…

生物大分子 · 定量生物学 2021-02-02 Kaifu Gao , Rui Wang , Jiahui Chen , Limei Cheng , Jaclyn Frishcosy , Yuta Huzumi , Yuchi Qiu , Tom Schluckbier , Guo-Wei Wei

The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat…

种群与进化 · 定量生物学 2021-12-21 Rajat Desikan , Pranesh Padmanabhan , Andrzej M. Kierzek , Piet H. van der Graaf

We investigate the quantum dynamics of ligand--receptor electron transfer and conformational response in a prototypical viral binding complex, using the SARS-CoV-2 Spike protein bound to the human ACE2 receptor as a model system. Treating…

量子物理 · 物理学 2026-04-28 Muhammad Waqas Haseeb , Mohamad Toutounji

Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capability, and a surprisingly high viral charge of symptom-less…

生物大分子 · 定量生物学 2021-06-10 Mattia Miotto , Lorenzo Di Rienzo , Leonardo Bò , Alberto Boffi , Giancarlo Ruocco , Edoardo Milanetti

In light of the continuing emergence of new SARS-CoV-2 variants and vaccines, we create a simulation framework for exploring possible infection trajectories under various scenarios. The situations of primary interest involve the interaction…

种群与进化 · 定量生物学 2022-01-10 Kory D. Johnson , Annemarie Grass , Daniel Toneian , Mathias Beiglböck , Jitka Polechová

How may exposure risks to SARS-CoV-2 be assessed quantitatively? The material metabolism approach of Industrial Ecology can be applied to the mass flows of these virions by their numbers, as a key step in the analysis of the current…

定量方法 · 定量生物学 2020-10-30 Gjalt Huppes , Ruben Huele

The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process…

The availability of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus data post-COVID has reached exponentially to an enormous magnitude, opening research doors to analyze its behavior. Various studies are conducted by…

神经与进化计算 · 计算机科学 2025-01-28 Taslim Murad , Prakash Chourasia , Sarwan Ali , Imdad Ullah Khan , Murray Patterson

The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the…

生物物理 · 物理学 2026-03-16 Rafael B. Frigori

The novel coronavirus (SARS-CoV-2) has led to a pandemic. The current testing regime based on Reverse Transcription-Polymerase Chain Reaction for SARS-CoV-2 has been unable to keep up with testing demands, and also suffers from a relatively…

We highlight changes to cell signalling under virus invasion (SARS-CoV-2), involving disturbance of membranes and of nanodomains, modulated by the cytoskeleton. Virus alters the mechanical properties of the membranes, impairing mesophase…

软凝聚态物质 · 物理学 2021-07-16 Christiane Binot , Jean-Francois Sadoc , Claude-Henri Chouard

The Coronavirus Disease 2019 (COVID-19) pandemic has infected over 10 million people globally with a relatively high mortality rate. There are many therapeutics undergoing clinical trials, but there is no effective vaccine or therapy for…

分子网络 · 定量生物学 2020-07-01 Fuhai Li , Andrew P. Michelson , Randi Foraker , Ming Zhan , Philip R. O. Payne
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