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We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

图像与视频处理 · 电气工程与系统科学 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Pathology Foundation Models (FMs) have shown strong performance across a wide range of pathology image representation and diagnostic tasks. However, FMs do not exhibit the expected performance advantage over traditional specialized models…

计算机视觉与模式识别 · 计算机科学 2026-03-05 Zijiang Yang , Chen Kuang , Dongmei Fu

Highly clumped nuclei clusters captured in fluorescence in situ hybridization microscopy images are common histology entities under investigations in a wide spectrum of tissue-related biomedical investigations. Due to their large scale in…

计算机视觉与模式识别 · 计算机科学 2018-08-15 Xiaoyuan Guo , Hanyi Yu , Blair Rossetti , George Teodoro , Daniel Brat , Jun Kong

In this paper, we introduced a novel feature extraction approach, named exclusive autoencoder (XAE), which is a supervised version of autoencoder (AE), able to largely improve the performance of nucleus detection and classification on…

计算机视觉与模式识别 · 计算机科学 2018-11-29 Chao-Hui Huang , Daniel Racoceanu

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

组织与器官 · 定量生物学 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Understanding the way cells communicate, co-locate, and interrelate is essential to understanding human physiology. Hematoxylin and eosin (H&E) staining is ubiquitously available both for clinical studies and research. The Colon Nucleus…

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

计算机视觉与模式识别 · 计算机科学 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Accurate segmentation and classification of nuclei in histology images is critical but challenging due to nuclei heterogeneity, staining variations, and tissue complexity. Existing methods often struggle with limited dataset variability,…

图像与视频处理 · 电气工程与系统科学 2025-01-22 Wenhua Zhang , Sen Yang , Meiwei Luo , Chuan He , Yuchen Li , Jun Zhang , Xiyue Wang , Fang Wang

The emerging area of computational pathology (CPath) is ripe ground for the application of deep learning (DL) methods to healthcare due to the sheer volume of raw pixel data in whole-slide images (WSIs) of cancerous tissue slides. However,…

图像与视频处理 · 电气工程与系统科学 2020-04-23 Jevgenij Gamper , Navid Alemi Koohbanani , Ksenija Benes , Simon Graham , Mostafa Jahanifar , Syed Ali Khurram , Ayesha Azam , Katherine Hewitt , Nasir Rajpoot

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

计算机视觉与模式识别 · 计算机科学 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

We present HoVer-UNet, an approach to distill the knowledge of the multi-branch HoVerNet framework for nuclei instance segmentation and classification in histopathology. We propose a compact, streamlined single UNet network with a Mix…

图像与视频处理 · 电气工程与系统科学 2023-12-05 Cristian Tommasino , Cristiano Russo , Antonio Maria Rinaldi , Francesco Ciompi

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps…

计算机视觉与模式识别 · 计算机科学 2024-01-25 Zhongyi Shui , Yunlong Zhang , Kai Yao , Chenglu Zhu , Sunyi Zheng , Jingxiong Li , Honglin Li , Yuxuan Sun , Ruizhe Guo , Lin Yang

Nuclei classification provides valuable information for histopathology image analysis. However, the large variations in the appearance of different nuclei types cause difficulties in identifying nuclei. Most neural network based methods are…

计算机视觉与模式识别 · 计算机科学 2023-02-23 Wei Lou , Xiang Wan , Guanbin Li , Xiaoying Lou , Chenghang Li , Feng Gao , Haofeng Li

Pathological diagnosis is the gold standard for tumor diagnosis, and nucleus instance segmentation is a key step in digital pathology analysis and pathological diagnosis. However, the computational efficiency of the model and the treatment…

图像与视频处理 · 电气工程与系统科学 2025-05-09 Shengchun Xiong , Xiangru Li , Yunpeng Zhong , Wanfen Peng

Instance segmentation and classification of nuclei is an important task in computational pathology. We show that StarDist, a deep learning nuclei segmentation method originally developed for fluorescence microscopy, can be extended and…

计算机视觉与模式识别 · 计算机科学 2022-08-22 Martin Weigert , Uwe Schmidt

Nuclear segmentation in histology images is a challenging task due to significant variations in the shape and appearance of nuclei. One of the main hurdles in nuclear instance segmentation is overlapping nuclei where a smart algorithm is…

图像与视频处理 · 电气工程与系统科学 2019-08-28 Navid Alemi Koohbanani , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Nuclear segmentation and classification is an essential step for computational pathology. TIA lab from Warwick University organized a nuclear segmentation and classification challenge (CoNIC) for H&E stained histopathology images in…

图像与视频处理 · 电气工程与系统科学 2022-03-22 Jijun Cheng , Xipeng Pan , Feihu Hou , Bingchao Zhao , Jiatai Lin , Zhenbing Liu , Zaiyi Liu , Chu Han

Brain tissue segmentation from multimodal MRI is a key building block of many neuroimaging analysis pipelines. Established tissue segmentation approaches have, however, not been developed to cope with large anatomical changes resulting from…

图像与视频处理 · 电气工程与系统科学 2020-11-05 Reuben Dorent , Thomas Booth , Wenqi Li , Carole H. Sudre , Sina Kafiabadi , Jorge Cardoso , Sebastien Ourselin , Tom Vercauteren

Skin cancer is a life-threatening disease where early detection significantly improves patient outcomes. Automated diagnosis from dermoscopic images is challenging due to high intra-class variability and subtle inter-class differences. Many…

计算机视觉与模式识别 · 计算机科学 2025-10-21 Md. Enamul Atiq , Shaikh Anowarul Fattah

Cancer is a leading cause of death worldwide, necessitating advancements in early detection and treatment technologies. In this paper, we present a novel and highly efficient melanoma detection framework that synergistically combines the…

图像与视频处理 · 电气工程与系统科学 2024-08-05 Peng Zhang , Divya Chaudhary