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Multiple-instance Learning (MIL) is commonly used to undertake computational pathology (CPath) tasks, and the use of multi-scale patches allows diverse features across scales to be learned. Previous studies using multi-scale features in…

计算机视觉与模式识别 · 计算机科学 2026-02-03 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A Fallowfield , Hakan Bilen , Timothy J Kendall

Multiple instance learning (MIL) has shown significant promise in histopathology whole slide image (WSI) analysis for cancer diagnosis and prognosis. However, the inherent spatial heterogeneity of WSIs presents critical challenges, as…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Junjian Li , Jin Liu , Hulin Kuang , Hailin Yue , Mengshen He , Jianxin Wang

Weakly Supervised Object Detection (WSOD), using only image-level annotations to train object detectors, is of growing importance in object recognition. In this paper, we propose a novel deep network for WSOD. Unlike previous networks that…

计算机视觉与模式识别 · 计算机科学 2018-10-16 Peng Tang , Xinggang Wang , Song Bai , Wei Shen , Xiang Bai , Wenyu Liu , Alan Yuille

In computational pathology, random sampling of patches during training of Multiple Instance Learning (MIL) methods is computationally efficient and serves as a regularization strategy. Despite its promising benefits, questions concerning…

计算机视觉与模式识别 · 计算机科学 2024-03-11 H. Keshvarikhojasteh , J. P. W. Pluim , M. Veta

Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…

图像与视频处理 · 电气工程与系统科学 2024-11-22 Manahil Raza , Ruqayya Awan , Raja Muhammad Saad Bashir , Talha Qaiser , Nasir M. Rajpoot

Multiple instance learning (MIL) is a promising approach for weakly supervised classification in pathology using whole slide images (WSIs). However, conventional MIL methods such as Attention-Based Deep Multiple Instance Learning (ABMIL)…

图像与视频处理 · 电气工程与系统科学 2025-04-28 Hassan Keshvarikhojasteh , Mihail Tifrea , Sibylle Hess , Josien P. W. Pluim , Mitko Veta

Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics…

计算机视觉与模式识别 · 计算机科学 2024-07-25 Junyu Li , Ye Zhang , Wen Shu , Xiaobing Feng , Yingchun Wang , Pengju Yan , Xiaolin Li , Chulin Sha , Min He

Multiple instance learning exhibits a powerful approach for whole slide image-based diagnosis in the absence of pixel- or patch-level annotations. In spite of the huge size of hole slide images, the number of individual slides is often…

Computational pathology (CPath) digitizes pathology slides into whole slide images (WSIs), enabling analysis for critical healthcare tasks such as cancer diagnosis and prognosis. However, WSIs possess extremely long sequence lengths (up to…

计算机视觉与模式识别 · 计算机科学 2025-12-04 Wenhao Tang , Heng Fang , Ge Wu , Xiang Li , Ming-Ming Cheng

In computational pathology, weak supervision has become the standard for deep learning due to the gigapixel scale of WSIs and the scarcity of pixel-level annotations, with Multiple Instance Learning (MIL) established as the principal…

计算机视觉与模式识别 · 计算机科学 2025-12-17 Andreas Lolos , Theofilos Christodoulou , Aris L. Moustakas , Stergios Christodoulidis , Maria Vakalopoulou

Computational pathology holds substantial promise for improving diagnosis and guiding treatment decisions. Recent pathology foundation models enable the extraction of rich patch-level representations from large-scale whole-slide images…

计算机视觉与模式识别 · 计算机科学 2025-11-20 Xiangde Luo , Jinxi Xiang , Yuanfeng Ji , Ruijiang Li

Detecting anomalies over real-world datasets remains a challenging task. Data annotation is an intensive human labor problem, particularly in sequential datasets, where the start and end time of anomalies are not known. As a result, data…

机器学习 · 计算机科学 2022-10-05 Parastoo Kamranfar , David Lattanzi , Amarda Shehu , Daniel Barbará

Multiple Instance Learning (MIL) is a weakly supervised learning problem where the aim is to assign labels to sets or bags of instances, as opposed to traditional supervised learning where each instance is assumed to be independent and…

机器学习 · 计算机科学 2022-02-24 Soumyasundar Pal , Antonios Valkanas , Florence Regol , Mark Coates

Given the special situation of modeling gigapixel images, multiple instance learning (MIL) has become one of the most important frameworks for Whole Slide Image (WSI) classification. In current practice, most MIL networks often face two…

计算机视觉与模式识别 · 计算机科学 2024-01-11 Pei Liu , Luping Ji , Xinyu Zhang , Feng Ye

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due…

计算机视觉与模式识别 · 计算机科学 2026-02-26 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Jiang Gui

In whole slide images (WSIs) analysis, attention-based multi-instance learning (MIL) models are susceptible to spurious correlations and degrade under domain shift. These methods may assign high attention weights to non-tumor regions, such…

计算机视觉与模式识别 · 计算机科学 2025-12-08 Xin Liu , Weijia Zhang , Wei Tang , Thuc Duy Le , Jiuyong Li , Lin Liu , Min-Ling Zhang

Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs).However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease…

图像与视频处理 · 电气工程与系统科学 2022-11-30 Xingyu Li , Jitendra Jonnagaddala , Min Cen , Hong Zhang , Xu Steven Xu

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

计算机视觉与模式识别 · 计算机科学 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the…

图像与视频处理 · 电气工程与系统科学 2024-08-07 Guillaume Jaume , Anurag Vaidya , Andrew Zhang , Andrew H. Song , Richard J. Chen , Sharifa Sahai , Dandan Mo , Emilio Madrigal , Long Phi Le , Faisal Mahmood

Convolutional neural networks (CNN) have achieved state of the art performance on both classification and segmentation tasks. Applying CNNs to microscopy images is challenging due to the lack of datasets labeled at the single cell level. We…

计算机视觉与模式识别 · 计算机科学 2017-05-25 Oren Z. Kraus , Lei Jimmy Ba , Brendan Frey