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In this work, we propose an approach for assessing sensitivity to unobserved confounding in studies with multiple outcomes. We demonstrate how prior knowledge unique to the multi-outcome setting can be leveraged to strengthen causal…

统计方法学 · 统计学 2023-01-26 Jiajing Zheng , Jiaxi Wu , Alexander D'Amour , Alexander Franks

Recent theoretical work in causal inference has explored an important class of variables which, when conditioned on, may further amplify existing unmeasured confounding bias (bias amplification). Despite this theoretical work, existing…

统计方法学 · 统计学 2020-03-20 Tyrel Stokes , Russell Steele , Ian Shrier

The present study investigates the performance of several statistical tests to detect publication bias in diagnostic meta-analysis by means of simulation. While bivariate models should be used to pool data from primary studies in diagnostic…

统计方法学 · 统计学 2022-11-24 Paul-Christian Bürkner , Philipp Doebler

We introduce several methods for assessing sensitivity to unmeasured confounding in marginal structural models; importantly we allow treatments to be discrete or continuous, static or time-varying. We consider three sensitivity models: a…

统计方法学 · 统计学 2022-10-12 Matteo Bonvini , Edward Kennedy , Valerie Ventura , Larry Wasserman

Scalable oversight protocols aim to empower evaluators to accurately verify AI models more capable than themselves. However, human evaluators are subject to biases that can lead to systematic errors. We conduct two studies examining the…

Inferring causal relationships or related associations from observational data can be invalidated by the existence of hidden confounding. We focus on a high-dimensional linear regression setting, where the measured covariates are affected…

统计方法学 · 统计学 2021-07-22 Zijian Guo , Domagoj Ćevid , Peter Bühlmann

The accurate representation of epistemic uncertainty is a challenging yet essential task in machine learning. A widely used representation corresponds to convex sets of probabilistic predictors, also known as credal sets. One popular way of…

机器学习 · 计算机科学 2025-07-30 Mira Jürgens , Thomas Mortier , Eyke Hüllermeier , Viktor Bengs , Willem Waegeman

Inferring causal relationships between variable pairs in the observational study is crucial but challenging, due to the presence of unmeasured confounding. While previous methods employed the negative controls to adjust for the confounding…

统计方法学 · 统计学 2025-10-21 Yong Wu , Yanwei Fu , Shouyan Wang , Yizhou Wang , Xinwei Sun

Causal understanding is a fundamental goal of evidence-based medicine. When randomization is impossible, causal inference methods allow the estimation of treatment effects from retrospective analysis of observational data. However, such…

机器学习 · 计算机科学 2024-11-06 Samuel Lee , Zach Wood-Doughty

Comparing composite models for multi-component observational data is a prevalent scientific challenge. When fitting composite models, there exists the potential for systematics from a poor fit of one model component to be absorbed by…

We consider the problem of testing a null hypothesis defined by equality and inequality constraints on a statistical parameter. Testing such hypotheses can be challenging because the number of relevant constraints may be on the same order…

统计方法学 · 统计学 2024-02-19 Nils Sturma , Mathias Drton , Dennis Leung

In this paper, we consider the extent of the biases that may arise when an unmeasured confounder is omitted from a structural equation model (SEM) and we propose sensitivity analysis techniques to correct for such biases. We give an…

统计方法学 · 统计学 2021-03-11 Adam J. Sullivan , Tyler J. VanderWeele

Consider sensitivity analysis for estimating average treatment effects under unmeasured confounding, assumed to satisfy a marginal sensitivity model. At the population level, we provide new representations for the sharp population bounds…

统计方法学 · 统计学 2022-09-26 Zhiqiang Tan

Missing data are often dealt with multiple imputation. A crucial part of the multiple imputation process is selecting sensible models to generate plausible values for incomplete data. A method based on posterior predictive checking is…

统计计算 · 统计学 2026-05-14 Mingyang Cai , Stef van Buuren , Gerko Vink

The possibility of unmeasured confounding is one of the main limitations for causal inference from observational studies. There are different methods for (partially) empirically assessing the plausibility of unconfoundedness. However, most…

统计方法学 · 统计学 2025-10-28 Fernando Pires Hartwig , Kate Tilling , George Davey Smith

Machine learning practice is often impacted by confounders. Confounding can be particularly severe in remote digital health studies where the participants self-select to enter the study. While many different confounding adjustment…

应用统计 · 统计学 2019-11-14 Elias Chaibub Neto , Meghasyam Tummalacherla , Lara Mangravite , Larsson Omberg

In designed experiments and surveys, known laws or design feat ures provide checks on the most relevant aspects of a model and identify the target parameters. In contrast, in most observational studies in the health and social sciences, the…

统计方法学 · 统计学 2010-01-18 Sander Greenland

Experimental and observational studies often lead to spurious association between the outcome and independent variables describing the intervention, because of confounding to third-party factors. Even in randomized clinical trials,…

统计方法学 · 统计学 2023-12-04 Orestis Loukas , Ho Ryun Chung

A major challenge in estimating treatment effects in observational studies is the reliance on untestable conditions such as the assumption of no unmeasured confounding. In this work, we propose an algorithm that can falsify the assumption…

统计方法学 · 统计学 2025-06-03 Rickard K. A. Karlsson , Jesse H. Krijthe

Covariate benchmarking is an important part of sensitivity analysis about omitted variable bias and can be used to bound the strength of the unobserved confounder using information and judgments about observed covariates. It is common to…

计量经济学 · 经济学 2023-06-21 Deepankar Basu