相关论文: Microscale characterisation of the time-dependent …
In biological tissue, MR transverse relaxation stems from mechanisms spanning multiple scales, from molecular dipole-dipole interactions to mesoscopic field variations driven by tissue microstructure. While mesoscopic relaxation reflects…
Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their…
Accurate estimation of microscopic magnetic field variations induced in biological tissue can be valuable for mapping tissue composition in health and disease. Here, we present an extension to Quantitative susceptibility mapping (QSM) to…
MRI provides a unique non-invasive window into the brain, yet is limited to millimeter resolution, orders of magnitude coarser than cell dimensions. Here we show that diffusion MRI is sensitive to the micrometer-scale variations in axon…
Conventional viscoelastic characterization of brain white matter (BWM), typically described using Prony series models, remains a largely empirical representation that is difficult to interpret physically. Growing evidence suggests that…
Understanding the mechanical behavior of brain tissue is crucial for advancing both fundamental neuroscience and clinical applications. Yet, accurately measuring these properties remains challenging due to the brain unique mechanical…
Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…
A diverse white matter network and finely tuned neuronal membrane properties allow the brain to transition seamlessly between cognitive states. However, it remains unclear how static structural connections guide the temporal progression of…
Magnetic susceptibility imaging may provide valuable information about chemical composition and microstructural organization of tissue. However, its estimation from the MRI signal phase is particularly difficult as it is sensitive to…
Functional magnetic resonance imaging (fMRI) is a neuroimaging technique known for its ability to capture brain activity non-invasively and at fine spatial resolution (2-3mm). Cortical surface fMRI (cs-fMRI) is a recent development of fMRI…
Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of measuring the local integrity along the…
Computational biomechanics models of the brain have become an important tool for investigating the brain responses to mechanical loads. The geometry, loading conditions, and constitutive properties of such brain models are well-studied and…
Mechanical models of brain tissue are a beneficial tool to simulate neurosurgical interventions, disease progression, or brain development. However, the accuracy and predictive capacity of such a model relies on a precise experimental…
Diffusion magnetic resonance imaging offers unique in vivo sensitivity to tissue microstructure in brain white matter, which undergoes significant changes during development and is compromised in virtually every neurological disorder. Yet,…
Larmor frequency shifts in white matter (WM) vary with fiber orientation due to anisotropic microstructure. Since clinical voxels are significantly larger than these microscopic frequency variations, the measured signal represents a bulk…
Functional Magnetic Resonance Imaging (fMRI) is a primary modality for studying brain activity. Modeling spatial dependence of imaging data at different scales is one of the main challenges of contemporary neuroimaging, and it could allow…
Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…
Axon diameter and myelin thickness affect the conduction velocity of action potentials in the nervous system. Imaging them non-invasively with MRI-based methods is thus valuable for studying brain microstructure and function. Electron…
Working memory (WM) allows information to be stored and manipulated over short time scales. Performance on WM tasks is thought to be supported by the frontoparietal system (FPS), the default mode system (DMS), and interactions between them.…
We have developed a novel scanning probe-based methodology to study cell biomechanics. The time dependence of the force exerted by the cell surface on a scanning probe at constant local deformation has been used to extract local…