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Speech is a critical biomarker for Huntington Disease (HD), with changes in speech increasing in severity as the disease progresses. Speech analyses are currently conducted using either transcriptions created manually by trained…

音频与语音处理 · 电气工程与系统科学 2020-08-11 Matthew Perez , Wenyu Jin , Duc Le , Noelle Carlozzi , Praveen Dayalu , Angela Roberts , Emily Mower Provost

Huntington disease (HD) is a fatal autosomal dominant neurocognitive disorder that causes cognitive disturbances, neuropsychiatric symptoms, and impaired motor abilities (e.g., gait, speech, voice). Due to its progressive nature, HD…

音频与语音处理 · 电气工程与系统科学 2020-10-20 Amrit Romana , John Bandon , Noelle Carlozzi , Angela Roberts , Emily Mower Provost

Automatic speech recognition (ASR) for pathological speech remains underexplored, especially for Huntington's disease (HD), where irregular timing, unstable phonation, and articulatory distortion challenge current models. We present a…

机器学习 · 计算机科学 2026-03-13 Charles L. Wang , Cady Chen , Ziwei Gong , Julia Hirschberg

Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory…

One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches…

音频与语音处理 · 电气工程与系统科学 2021-11-22 Adedolapo Aishat Toye , Suryaprakash Kompalli

This study investigates the speech articulatory coordination in schizophrenia subjects exhibiting strong positive symptoms (e.g. hallucinations and delusions), using two distinct channel-delay correlation methods. We show that the…

音频与语音处理 · 电气工程与系统科学 2023-05-18 Yashish M. Siriwardena , Chris Kitchen , Deanna L. Kelly , Carol Espy-Wilson

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbances, and cognitive decline. The onset of HD is marked by severe motor impairment, which may be predicted…

统计方法学 · 统计学 2026-02-17 Yue Zhan , Cheng Zheng , Ying Zhang

Hypernasality is a common characteristic symptom across many motor-speech disorders. For voiced sounds, hypernasality introduces an additional resonance in the lower frequencies and, for unvoiced sounds, there is reduced articulatory…

音频与语音处理 · 电气工程与系统科学 2020-09-14 Michael Saxon , Ayush Tripathi , Yishan Jiao , Julie Liss , Visar Berisha

Conventionally, the manner of articulations in speech signal are derived using discriminative signal processing techniques or deep learning approaches. However, training such complex systems involves feature extraction, phoneme force…

音频与语音处理 · 电气工程与系统科学 2018-11-06 Pradeep R , Sreenivasa Rao K

Objective: This study aimed to evaluate which voice features can predict health deterioration in patients with chronic HF. Background: Heart failure (HF) is a chronic condition with progressive deterioration and acute decompensations, often…

Multi-resolution spectro-temporal features of a speech signal represent how the brain perceives sounds by tuning cortical cells to different spectral and temporal modulations. These features produce a higher dimensional representation of…

音频与语音处理 · 电气工程与系统科学 2022-06-28 Rahil Parikh , Nadee Seneviratne , Ganesh Sivaraman , Shihab Shamma , Carol Espy-Wilson

For Huntington disease, identification of brain regions related to motor impairment can be useful for developing interventions to alleviate the motor symptom, the major symptom of the disease. However, the effects from the brain regions to…

统计方法学 · 统计学 2020-07-14 Rakheon Kim , Samuel Mueller , Tanya P. Garcia

Multimodal depression classification has gained immense popularity over the recent years. We develop a multimodal depression classification system using articulatory coordination features extracted from vocal tract variables and text…

音频与语音处理 · 电气工程与系统科学 2022-02-15 Nadee Seneviratne , Carol Espy-Wilson

This paper presents a widespread analysis of affective vocal expression classification systems. In this study, state-of-the-art acoustic features are compared to two novel affective vocal prints for the detection of emotional states: the…

音频与语音处理 · 电气工程与系统科学 2019-10-07 V. Vieira , R. Coelho , F. Assis

Automated detection of voice disorders with computational methods is a recent research area in the medical domain since it requires a rigorous endoscopy for the accurate diagnosis. Efficient screening methods are required for the diagnosis…

定量方法 · 定量生物学 2018-12-06 Vibhuti Gupta

Imprecise vowel articulation can be observed in people with Parkinson's disease (PD). Acoustic features measuring vowel articulation have been demonstrated to be effective indicators of PD in its assessment. Standard clinical vowel…

音频与语音处理 · 电气工程与系统科学 2021-08-18 Yuanyuan Liu , Nelly Penttilä , Tiina Ihalainen , Juulia Lintula , Rachel Convey , Okko Räsänen

This study investigates the speech articulatory coordination in schizophrenia subjects exhibiting strong positive symptoms (e.g.hallucinations and delusions), using a time delay embedded correlation analysis. We show that the schizophrenia…

音频与语音处理 · 电气工程与系统科学 2021-02-16 Yashish Maduwantha H. P. E. R. S , Chris Kitchen , Deanna L. Kelly , Carol Espy-Wilson

Stuttering is a complex speech disorder that can be identified by repetitions, prolongations of sounds, syllables or words, and blocks while speaking. Severity assessment is usually done by a speech therapist. While attempts at automated…

定量方法 · 定量生物学 2020-06-17 Sebastian P. Bayerl , Florian Hönig , Joelle Reister , Korbinian Riedhammer

The incidence rate of voice diseases is increasing year by year. The use of software for remote diagnosis is a technical development trend and has important practical value. Among voice diseases, common diseases that cause hoarseness…

声音 · 计算机科学 2023-04-19 Xiaoping Xie , Hao Cai , Can Li , Fei Ding

This paper integrates a voice activity detection (VAD) function with end-to-end automatic speech recognition toward an online speech interface and transcribing very long audio recordings. We focus on connectionist temporal classification…

音频与语音处理 · 电气工程与系统科学 2020-03-16 Takenori Yoshimura , Tomoki Hayashi , Kazuya Takeda , Shinji Watanabe
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