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Foundation models for computational pathology have shown great promise for specimen-level tasks and are increasingly accessible to researchers. However, specimen-level models built on these foundation models remain largely unavailable,…

图像与视频处理 · 电气工程与系统科学 2025-01-13 Jakub R. Kaczmarzyk , Rishul Sharma , Peter K. Koo , Joel H. Saltz

Modern histopathological image analysis relies on the segmentation of cell structures to derive quantitative metrics required in biomedical research and clinical diagnostics. State-of-the-art deep learning approaches predominantly apply…

图像与视频处理 · 电气工程与系统科学 2022-01-12 Yoav Alon , Huiyu Zhou

Liver cancer, especially hepatocellular carcinoma (HCC), imposes a substantial global disease burden. Accurate diagnosis and prognostic assessment directly influence treatment selection and patient survival, and pathological examination…

计算机视觉与模式识别 · 计算机科学 2026-04-28 Ying Xiao , Shimiao Tang , Xitong Ling , Weiming Chen , Jun Wang , Jiawen Li , Huaitian Yuan , Jianghui Yang , Bowen Li , Huan Li , Yiting Meng , Tian Guan , Yonghong He , Hongfang Yin

The ability to dynamically extend a model to new data and classes is critical for multiple organ and tumor segmentation. However, due to privacy regulations, accessing previous data and annotations can be problematic in the medical domain.…

图像与视频处理 · 电气工程与系统科学 2023-07-24 Yixiao Zhang , Xinyi Li , Huimiao Chen , Alan Yuille , Yaoyao Liu , Zongwei Zhou

Nuclei instance segmentation plays an important role in the analysis of Hematoxylin and Eosin (H&E)-stained images. While supervised deep learning (DL)-based approaches represent the state-of-the-art in automatic nuclei instance…

图像与视频处理 · 电气工程与系统科学 2021-03-25 Amirreza Mahbod , Gerald Schaefer , Benjamin Bancher , Christine Löw , Georg Dorffner , Rupert Ecker , Isabella Ellinger

Mitotic activity is a crucial proliferation biomarker for the diagnosis and prognosis of different types of cancers. Nevertheless, mitosis counting is a cumbersome process for pathologists, prone to low reproducibility, due to the large…

图像与视频处理 · 电气工程与系统科学 2022-12-01 Claudio Fernandez-Martín , Umay Kiraz , Julio Silva-Rodríguez , Sandra Morales , Emiel Janssen , Valery Naranjo

Cancer diseases constitute one of the most significant societal challenges. In this paper, we introduce a novel histopathological dataset for prostate cancer detection. The proposed dataset, consisting of over 2.6 million tissue patches…

Robust automated organ segmentation is a prerequisite for computer-aided diagnosis (CAD), quantitative imaging analysis and surgical assistance. For high-variability organs such as the pancreas, previous approaches report undesirably low…

计算机视觉与模式识别 · 计算机科学 2016-03-08 Amal Farag , Le Lu , Holger R. Roth , Jiamin Liu , Evrim Turkbey , Ronald M. Summers

The NuCLS dataset contains over 220.000 annotations of cell nuclei in breast cancers. We show how to use these data to create a multi-rater model with the MIScnn Framework to automate the analysis of cell nuclei. For the model creation, we…

计算机视觉与模式识别 · 计算机科学 2023-02-02 Adrian Pfleiderer , Dominik Müller , Frank Kramer

Deep learning has achieved spectacular performance in image and speech recognition and synthesis. It outperforms other machine learning algorithms in problems where large amounts of data are available. In the area of measurement technology,…

定量方法 · 定量生物学 2019-08-20 Yueqin Li , Ata Mahjoubfar , Claire Lifan Chen , Kayvan Reza Niazi , Li Pei , Bahram Jalali

Computer-assisted surgery research requires large, deeply annotated video datasets that capture clinical and technical variability. Existing cataract surgery resources lack the diversity and annotation depth required to train generalizable…

We address the problem of supporting radiologists in the longitudinal management of lung cancer. Therefore, we proposed a deep learning pipeline, composed of four stages that completely automatized from the detection of nodules to the…

图像与视频处理 · 电气工程与系统科学 2021-03-29 Xavier Rafael-Palou , Anton Aubanell , Mario Ceresa , Vicent Ribas , Gemma Piella , Miguel A. González Ballester

Advancing AI in computational pathology requires large, high-quality, and diverse datasets, yet existing public datasets are often limited in organ diversity, class coverage, or annotation quality. To bridge this gap, we introduce SPIDER…

图像与视频处理 · 电气工程与系统科学 2025-04-08 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

Automated cervical nucleus segmentation based on deep learning can effectively improve the quantitative analysis of cervical cancer. However, accurate nuclei segmentation is still challenging. The classic U-net has not achieved satisfactory…

图像与视频处理 · 电气工程与系统科学 2019-11-13 Jie Zhao , Lei Dai , Mo Zhang , Fei Yu , Meng Li , Hongfeng Li , Wenjia Wang , Li Zhang

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited…

计算机视觉与模式识别 · 计算机科学 2025-08-20 Zhixuan Chen , Junlin Hou , Liqi Lin , Yihui Wang , Yequan Bie , Xi Wang , Yanning Zhou , Ronald Cheong Kin Chan , Hao Chen

Computational pathology (CPath) digitizes pathology slides into whole slide images (WSIs), enabling analysis for critical healthcare tasks such as cancer diagnosis and prognosis. However, WSIs possess extremely long sequence lengths (up to…

计算机视觉与模式识别 · 计算机科学 2025-12-04 Wenhao Tang , Heng Fang , Ge Wu , Xiang Li , Ming-Ming Cheng

Objective: Medical image datasets with pixel-level labels tend to have a limited number of organ or tissue label classes annotated, even when the images have wide anatomical coverage. With supervised learning, multiple classifiers are…

Annotation ambiguity due to inherent data uncertainties such as blurred boundaries in medical scans and different observer expertise and preferences has become a major obstacle for training deep-learning based medical image segmentation…

计算机视觉与模式识别 · 计算机科学 2024-03-21 Yicheng Wu , Xiangde Luo , Zhe Xu , Xiaoqing Guo , Lie Ju , Zongyuan Ge , Wenjun Liao , Jianfei Cai

Progress in biomedical Named Entity Recognition (NER) and Entity Linking (EL) is currently hindered by a fragmented data landscape, a lack of resources for building explainable models, and the limitations of semantically-blind evaluation…

计算与语言 · 计算机科学 2025-11-17 Nishant Mishra , Wilker Aziz , Iacer Calixto

Nuclei segmentation is the cornerstone task in histology image reading, shedding light on the underlying molecular patterns and leading to disease or cancer diagnosis. Yet, it is a laborious task that requires expertise from trained…

图像与视频处理 · 电气工程与系统科学 2025-11-10 Vasileios Magoulianitis , Catherine A. Alexander , Jiaxin Yang , C. -C. Jay Kuo