相关论文: On growth, buckling, and rupture of aneurysms

Rupture of aortic aneurysms is by far the most fatal heart disease, with a mortality rate exceeding 80%. There are no reliable clinical protocols to predict growth, dissection, and rupture because the fundamental physics driving aneurysm…

Mechanical instability in a pre-tensioned finite hyperelastic tube subjected to a slowly increasing internal pressure produces a spatially localized bulge at a critical pressure. The subsequent fate of the bulge, under continued inflation,…

The basic mechanism driving aneurysm growth is unknown. Currently, clinical diagnosis of an aneurysm is mainly informed by retrospective tracking of its size and growth rate. However, aneurysms can rupture before reactive criteria are met…

We study the initiation and evolution of aneurysmal morphology in a pressurized soft tube where the elastic modulus is non-uniform in the radial direction. The primary deformation prior to instability is characterized within the framework…

Buckling instabilities driven by tissue growth underpin key developmental events such as the folding of the brain. Tissue growth is disordered due to cell-to-cell variability, but the effects of this variability on buckling are unknown.…

Cerebral aneurysm progression is a result of a complex interplay of the biomechanical and clinical risk factors that drive aneurysmal growth and rupture. Subjects with multiple aneurysms are unique cases wherein clinical risk factors are…

Arterial aneurysm (Fig.1) is a bulb-shape local expansion of human arteries, the rupture of which is a leading cause of morbidity and mortality in US. Therefore, the prediction of arterial aneurysm rupture is of great significance for…

Growth-induced instabilities are ubiquitous in biological systems and lead to diverse morphologies in the form of wrinkling, folding, and creasing. The current work focusses on the mechanics behind growth-induced wrinkling instabilities in…

We evaluate the loss of stability of axially compressed slender and thick-walled tubes subject to a residual stress distribution. The nonlinear theory of elasticity, when used to analyze the underlying deformation, shows that the residual…

Obstructions influence the growth and expansion of bodies in a wide range of settings -- but isolating and understanding their impact can be difficult in complex environments. Here, we study obstructed growth/expansion in a model system…

We study how crack buckling affects stress and strain in a thin sheet with random disorder. The sheet is modeled as an elastic lattice of beams where each of the beams have individual thresholds for breaking. A statistical distribution with…

The buckling of a soft elastic sample under growth or swelling has highlighted a new interest in materials science, morphogenesis, and biology or physiology. Indeed, the change of mass or volume is a common fact of any living species, and…

The experimental actualisation of organoids modelling organs from brains to pancreases has revealed that much of the diverse morphologies of organs are emergent properties of simple intercellular "rules" and not the result of top-down…

An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta which, if left untreated, can progressively widen and may rupture with fatal consequences. In this paper, we determine an optimal treatment policy using Markov…

Clinical decisions for unruptured intracranial aneurysms depend on detecting growth on follow-up magnetic resonance angiography (MRA). Growth is typically judged from manual 2D diameters on few slices, which vary across clinicians and…

Hollow microgels are elastic polymer shells easily realizable in experiments. Recent works have shown the emergence of buckling events in dilute hollow microgels under the effect of an added osmotic pressure. Here, we perform large-scale…

We investigate the stability of the deformation modeled by the opening angle method, often used to give a measure of residual stresses in arteries and other biological soft tubular structures. Specifically, we study the influence of…

Cerebral aneurysms and microaneurysms are abnormal vascular dilatations with high risk of rupture. An aneurysmal rupture could cause permanent disability and even death. Finding and treating aneurysms before their rupture is very difficult…

A slender object undergoing an axial compression will buckle to alleviate the stress. Typically the morphology of the deformed object depends on the bending stiffness for solids, or the viscoelastic properties for liquid threads. We study a…

We study theoretically the shapes of biological tubes affected by various pathologies. When epithelial cells grow at an uncontrolled rate, the negative tension produced by their division provokes a buckling instability. Several shapes are…