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This study evaluates the generalisation capabilities of state-of-the-art histopathology foundation models on out-of-distribution multi-stain autoimmune Immunohistochemistry datasets. We compare 13 feature extractor models, including…

计算机视觉与模式识别 · 计算机科学 2024-10-30 Amaya Gallagher-Syed , Elena Pontarini , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Cytoarchitecture describes the spatial organization of neuronal cells in the brain, including their arrangement into layers and columns with respect to cell density, orientation, or presence of certain cell types. It allows to segregate the…

图像与视频处理 · 电气工程与系统科学 2022-01-02 Christian Schiffer , Stefan Harmeling , Katrin Amunts , Timo Dickscheid

Interpretability is significant in computational pathology, leading to the development of multimodal information integration from histopathological image and corresponding text data.However, existing multimodal methods have limited…

计算机视觉与模式识别 · 计算机科学 2026-01-22 Kangcheng Zhou , Jun Jiang , Qing Zhang , Shuang Zheng , Qingli Li , Shugong Xu

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

计算机视觉与模式识别 · 计算机科学 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

In clinical artificial intelligence (AI), graph representation learning, mainly through graph neural networks (GNNs), stands out for its capability to capture intricate relationships within structured clinical datasets. With diverse data --…

机器学习 · 计算机科学 2023-12-13 Ruth Johnson , Michelle M. Li , Ayush Noori , Owen Queen , Marinka Zitnik

Accurate diagnosis and prognosis assisted by pathology images are essential for cancer treatment selection and planning. Despite the recent trend of adopting deep-learning approaches for analyzing complex pathology images, they fall short…

计算机视觉与模式识别 · 计算机科学 2025-04-23 Awais Naeem , Tianhao Li , Huang-Ru Liao , Jiawei Xu , Aby M. Mathew , Zehao Zhu , Zhen Tan , Ajay Kumar Jaiswal , Raffi A. Salibian , Ziniu Hu , Tianlong Chen , Ying Ding

There is an ongoing need for scalable tools to aid researchers in both retrospective and prospective standardization of discrete entity types -- such as disease names, cell types or chemicals -- that are used in metadata associated with…

数据库 · 计算机科学 2024-07-04 Rafael S. Gonçalves , Jason Payne , Amelia Tan , Carmen Benitez , Jamie Haddock , Robert Gentleman

Histopathology image segmentation is essential for delineating tissue structures in skin cancer diagnostics, but modeling spatial context and inter-tissue relationships remains a challenge, especially in regions with overlapping or…

计算机视觉与模式识别 · 计算机科学 2026-05-12 Shravan Venkatraman , Muthu Subash Kavitha , Joe Dhanith P R , V Manikandarajan , Jia Wu

Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

图像与视频处理 · 电气工程与系统科学 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

Purpose: As interest in CEST-MRI grows, particularly in the preclinical setting, the necessity for standardized and easy-to-use acquisition and data analysis pipelines has become apparent. While vendors have increasingly introduced support…

Knowledge is captured in the form of entities and their relationships and stored in knowledge graphs. Knowledge graphs enhance the capabilities of applications in many different areas including Web search, recommendation, and natural…

机器学习 · 计算机科学 2021-03-31 Kalpa Gunaratna , Yu Wang , Hongxia Jin

Whole-slide image analysis is essential for diagnostic tasks in pathology, yet existing deep learning methods primarily rely on flat classification, ignoring hierarchical relationships among class labels. In this study, we propose HiClass,…

计算机视觉与模式识别 · 计算机科学 2026-03-03 Keunho Byeon , Jinsol Song , Seong Min Hong , Yosep Chong , Jin Tae Kwak

Medical domain automated text generation is an active area of research and development; however, evaluating the clinical quality of generated reports remains a challenge, especially in instances where domain-specific metrics are lacking,…

计算与语言 · 计算机科学 2025-09-23 Yunsoo Kim , Michal W. S. Ong , Alex Shavick , Honghan Wu , Adam P. Levine

Foundation models are trained on massive amounts of data to distinguish complex patterns and can be adapted to a wide range of downstream tasks with minimal computational resources. Here, we develop a foundation model for prostate cancer…

图像与视频处理 · 电气工程与系统科学 2024-11-25 Joona Pohjonen , Abderrahim-Oussama Batouche , Antti Rannikko , Kevin Sandeman , Andrew Erickson , Esa Pitkanen , Tuomas Mirtti

There is a significant need for the generation of virtual histological information from coronary optical coherence tomography (OCT) images to better guide the treatment of coronary artery disease. However, existing methods either require a…

图像与视频处理 · 电气工程与系统科学 2023-07-25 Xueshen Li , Hongshan Liu , Xiaoyu Song , Brigitta C. Brott , Silvio H. Litovsky , Yu Gan

Ontologies are formal representations of concepts and complex relationships among them. They have been widely used to capture comprehensive domain knowledge in areas such as biology and medicine, where large and complex ontologies can…

人机交互 · 计算机科学 2019-10-24 Ying Yang , Michael Wybrow , Yuan-Fang Li , Tobias Czauderna , Yongqun He

Precision medicine has become a central focus in breast cancer management, advancing beyond conventional methods to deliver more precise and individualized therapies. Traditionally, histopathology images have been used primarily for…

定量方法 · 定量生物学 2024-12-17 Suchithra Kunhoth , Somaya Al- Maadeed , Younes Akbari , Rafif Al Saady

Artificial Intelligence (AI) brings advancements to support pathologists in navigating high-resolution tumor images to search for pathology patterns of interest. However, existing AI-assisted tools have not realized this promised potential…

The central nervous system is composed of many individual units -- from cells to areas -- that are connected with one another in a complex pattern of functional interactions that supports perception, action, and cognition. One natural and…

神经元与认知 · 定量生物学 2017-04-03 Ann E. Sizemore , Danielle S. Bassett

Virtual stain transfer is a promising area of research in Computational Pathology, which has a great potential to alleviate important limitations when applying deeplearningbased solutions such as lack of annotations and sensitivity to a…

计算机视觉与模式识别 · 计算机科学 2022-10-19 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert