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In mammalian and vertebrate genomes, the promoter regions of the gene and their distal enhancers may be located millions of base-pairs from each other, while a promoter may not interact with the closest enhancer. Since base-pair proximity…

机器学习 · 计算机科学 2025-04-02 Muhammad Tahir , Shehroz S. Khan , James Davie , Soichiro Yamanaka , Ahmed Ashraf

The problem of dynamic prediction with time-dependent covariates, given by biomarkers, repeatedly measured over time, has received much attention over the last decades. Two contrasting approaches have become in widespread use. The first is…

统计方法学 · 统计学 2021-03-31 Hein Putter , Hans C. van Houwelingen

Cross-Validation (CV) is the default choice for evaluating the performance of machine learning models. Despite its wide usage, their statistical benefits have remained half-understood, especially in challenging nonparametric regimes. In…

统计理论 · 数学 2024-08-22 Garud Iyengar , Henry Lam , Tianyu Wang

The paper considers the problem of out-of-sample risk estimation under the high dimensional settings where standard techniques such as $K$-fold cross validation suffer from large biases. Motivated by the low bias of the leave-one-out cross…

统计方法学 · 统计学 2020-02-12 Kamiar Rahnama Rad , Arian Maleki

In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the…

机器学习 · 统计学 2022-06-08 Susan Athey , Guido Imbens

Vision-language (VL) models, pretrained on colossal image-text datasets, have attained broad VL competence that is difficult to evaluate. A common belief is that a small number of VL skills underlie the variety of VL tests. In this paper,…

计算机视觉与模式识别 · 计算机科学 2024-04-04 Anthony Meng Huat Tiong , Junqi Zhao , Boyang Li , Junnan Li , Steven C. H. Hoi , Caiming Xiong

Current evaluations of Continual Learning (CL) methods typically assume that there is no constraint on training time and computation. This is an unrealistic assumption for any real-world setting, which motivates us to propose: a practical…

This paper presents a novel positive and negative set selection strategy for contrastive learning of medical images based on labels that can be extracted from clinical data. In the medical field, there exists a variety of labels for data…

计算机视觉与模式识别 · 计算机科学 2023-05-25 Kiran Kokilepersaud , Stephanie Trejo Corona , Mohit Prabhushankar , Ghassan AlRegib , Charles Wykoff

Objective: In randomized clinical trials, prediction models can be used to explore the relationships between patients' variables (e.g., clinical, pathological, or lifestyle variables, and also biomarker or genomic data) and treatment effect…

定量方法 · 定量生物学 2026-02-03 Elvire Roblin , Paul-Henry Cournède , Stefan Michiels

Datasets used in immunotherapy response prediction are typically small in size, as well as diverse in cancer type, drug administered, and sequencer used. Models often drop in performance when tested on patient cohorts that are not included…

机器学习 · 计算机科学 2026-04-02 Sayed Hashim , Frank Soboczenski , Paul Cairns

Medical Large language models achieve strong scores on standard benchmarks; however, the transfer of those results to safe and reliable performance in clinical workflows remains a challenge. This survey reframes evaluation through a…

Early prediction of mortality and length of stay(LOS) of a patient is vital for saving a patient's life and management of hospital resources. Availability of electronic health records(EHR) makes a huge impact on the healthcare domain and…

机器学习 · 计算机科学 2020-12-01 Batuhan Bardak , Mehmet Tan

Analyzing and inspecting bone marrow cell cytomorphology is a critical but highly complex and time-consuming component of hematopathology diagnosis. Recent advancements in artificial intelligence have paved the way for the application of…

计算机视觉与模式识别 · 计算机科学 2022-05-23 Shayan Fazeli , Alireza Samiei , Thomas D. Lee , Majid Sarrafzadeh

Cellwise contamination remains a challenging problem for data scientists, particularly in research fields that require the selection of sparse features. Traditional robust methods may not be feasible nor efficient in dealing with such…

统计方法学 · 统计学 2024-03-04 Peng Su , Garth Tarr , Samuel Muller , Suojin Wang

This paper investigates the efficiency of the K-fold cross-validation (CV) procedure and a debiased version thereof as a means of estimating the generalization risk of a learning algorithm. We work under the general assumption of uniform…

统计理论 · 数学 2023-06-13 Anass Aghbalou , François Portier , Anne Sabourin

Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are often continuous measurements.…

Cancer prognosis is a critical task that involves predicting patient outcomes and survival rates. To enhance prediction accuracy, previous studies have integrated diverse data modalities, such as clinical notes, medical images, and genomic…

机器学习 · 计算机科学 2025-02-04 Jie Peng , Shuang Zhou , Longwei Yang , Yiran Song , Mohan Zhang , Kaixiong Zhou , Feng Xie , Mingquan Lin , Rui Zhang , Tianlong Chen

Many medical decisions involve the use of dynamic information collected on individual patients toward predicting likely transitions in their future health status. If accurate predictions are developed, then a prognostic mode can identify…

统计方法学 · 统计学 2018-02-22 Aasthaa Bansal , Patrick J. Heagerty

Randomized clinical trials are the gold standard for analyzing treatment effects, but high costs and ethical concerns can limit recruitment, potentially leading to invalid inferences. Incorporating external trial data with similar…

统计方法学 · 统计学 2024-09-09 Yujia Gu , Hanzhong Liu , Wei Ma

We propose a novel method for estimating heterogeneous treatment effects based on the fused lasso. By first ordering samples based on the propensity or prognostic score, we match units from the treatment and control groups. We then run the…