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Our aim is to establish a framework where reinforcement learning (RL) of optimizing interventions retrospectively allows us a regulatory compliant pathway to prospective clinical testing of the learned policies in a clinical deployment. We…

机器学习 · 计算机科学 2020-03-20 Luchen Li , Ignacio Albert-Smet , Aldo A. Faisal

In recent years, machine learning has become an increasingly powerful tool for supporting seizure detection and monitoring in epilepsy care. Traditional approaches focus on identifying seizures only after they begin, which limits the…

机器学习 · 计算机科学 2025-10-30 Ria Jayanti , Tanish Jain

The intensive care unit (ICU) comprises a complex hospital environment, where decisions made by clinicians have a high level of risk for the patients' lives. A comprehensive care pathway must then be followed to reduce p complications.…

Sepsis is a potentially life threatening inflammatory response to infection or severe tissue damage. It has a highly variable clinical course, requiring constant monitoring of the patient's state to guide the management of intravenous…

机器学习 · 计算机科学 2022-02-21 Thesath Nanayakkara , Gilles Clermont , Christopher James Langmead , David Swigon

Heart attack remain one of the greatest contributors to mortality in the United States and globally. Patients admitted to the intensive care unit (ICU) with diagnosed heart attack (myocardial infarction or MI) are at higher risk of death.…

机器学习 · 计算机科学 2023-05-11 Munib Mesinovic , Peter Watkinson , Tingting Zhu

Background: Patients with both diabetes mellitus (DM) and atrial fibrillation (AF) face elevated mortality in intensive care units (ICUs), yet models targeting this high-risk group remain limited. Objective: To develop an interpretable…

机器学习 · 计算机科学 2025-06-23 Li Sun , Shuheng Chen , Yong Si , Junyi Fan , Maryam Pishgar , Elham Pishgar , Kamiar Alaei , Greg Placencia

This paper introduces an innovative framework designed for progressive (granular in time to onset) prediction of seizures through the utilization of a Deep Learning (DL) methodology based on non-invasive multi-modal sensor networks.…

信号处理 · 电气工程与系统科学 2024-11-05 Ali Saeizadeh , Douglas Schonholtz , Joseph S. Neimat , Pedram Johari , Tommaso Melodia

We develop a deep learning approach to predicting a set of ventilator parameters for a mechanically ventilated septic patient using a long and short term memory (LSTM) recurrent neural network (RNN) model. We focus on short-term predictions…

定量方法 · 定量生物学 2022-02-23 Zhijun Zeng , Zhen Hou , Ting Li , Lei Deng , Jianguo Hou , Xinran Huang , Jun Li , Meirou Sun , Yunhan Wang , Qiyu Wu , Wenhao Zheng , Hua Jiang , Qi Wang

Intensive care clinicians are presented with large quantities of patient information and measurements from a multitude of monitoring systems. The limited ability of humans to process such complex information hinders physicians to readily…

Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be…

机器学习 · 计算机科学 2018-12-13 Laura A. Barrett , Seyedeh Neelufar Payrovnaziri , Jiang Bian , Zhe He

Objective: Sepsis is one of the most serious hospital conditions associated with high mortality. Sepsis is the result of a dysregulated immune response to infection that can lead to multiple organ dysfunction and death. Due to the wide…

We applied machine learning to the unmet medical need of rapid and accurate diagnosis and prognosis of acute infections and sepsis in emergency departments. Our solution consists of a Myrna (TM) Instrument and embedded TriVerity (TM)…

Fever can provide valuable information for diagnosis and prognosis of various diseases such as pneumonia, dengue, sepsis, etc., therefore, predicting fever early can help in the effectiveness of treatment options and expediting the…

定量方法 · 定量生物学 2020-09-16 Aditya Singh , Akram Mohammed , Lokesh Chinthala , Rishikesan Kamaleswaran

ICU readmission is associated with longer hospitalization, mortality and adverse outcomes. An early recognition of ICU re-admission can help prevent patients from worse situation and lower treatment cost. As the abundance of Electronics…

机器学习 · 计算机科学 2019-10-08 Zhiheng Li , Xinyue Xing , Bingzhang Lu , Zhixiang Li

Extensive bedside monitoring in Intensive Care Units (ICUs) has resulted in complex temporal data regarding patient physiology, which presents an upscale context for clinical data analysis. In the other hand, identifying the time-series…

机器学习 · 计算机科学 2023-08-25 Manel Mili , Asma Kerkeni , Asma Ben Abdallah , Mohamed Hedi Bedoui

The early and accurate diagnosis of sepsis is critical for enhancing patient outcomes. This study aims to use heart rate variability (HRV) features to develop an effective predictive model for sepsis detection. Critical HRV features are…

机器学习 · 计算机科学 2024-08-07 Sai Balaji , Christopher Sun , Anaiy Somalwar

Sepsis-induced acute respiratory failure (ARF) is a serious complication with a poor prognosis. This paper presents a deep representation learningbased phenotyping method to identify distinct groups of clinical trajectories of septic…

信号处理 · 电气工程与系统科学 2024-05-07 Alan Wu , Tilendra Choudhary , Pulakesh Upadhyaya , Ayman Ali , Philip Yang , Rishikesan Kamaleswaran

Hypertension and atrial fibrillation (AF) often coexist in critically ill patients, significantly increasing mortality rates in the ICU. Early identification of high-risk individuals is crucial for targeted interventions. However, limited…

应用统计 · 统计学 2025-06-19 Shuheng Chen , Yong Si , Junyi Fan , Li Sun , Greg Placencia , Elham Pishgar , Kamiar Alaei , Maryam Pishgar

Background: Hypertensive kidney disease (HKD) patients in intensive care units (ICUs) face high short-term mortality, but tailored risk prediction tools are lacking. Early identification of high-risk individuals is crucial for clinical…

机器学习 · 计算机科学 2025-07-28 Yong Si , Junyi Fan , Li Sun , Shuheng Chen , Minoo Ahmadi , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Sepsis remains one of the most complex and heterogeneous syndromes in intensive care, characterized by diverse physiological trajectories and variable responses to treatment. While deep learning models perform well in the early prediction…

机器学习 · 计算机科学 2026-04-01 Vincent Lemaire , Nédra Meloulli , Pierre Jaquet