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The exceptional electronic, optical and chemical properties of two-dimensional materials strongly depend on the 3D atomic structure and crystal defects. Using Re-doped MoS2 as a model, here we develop scanning atomic electron tomography…

The aim of this paper is to give an introductory review of the cryoelectron microscopy as a complex data source for the most of the system biology branches, including the most perspective non-local approaches known as "localomics" and…

亚细胞过程 · 定量生物学 2015-01-20 Oleg V. Gradov , Margaret A. Gradova

Electron, optical, and scanning probe microscopy methods are generating ever increasing volume of image data containing information on atomic and mesoscale structures and functionalities. This necessitates the development of the machine…

机器学习 · 计算机科学 2023-04-03 Mani Valleti , Yongtao Liu , Sergei Kalinin

We target the problem of estimating the center of mass of noisy 2-D images. We assume that the noise dominates the image, and thus many standard approaches are vulnerable to estimation errors. Our approach uses a surrogate function to the…

图像与视频处理 · 电气工程与系统科学 2021-03-04 Ayelet Heimowitz , Nir Sharon , Amit Singer

Three-dimensional electron diffraction (3DED) is a powerful technique providing for crystal structure solutions of sub-micron sized crystals too small for structure determination via X-ray techniques. The entry requirement, however, of a…

Electrical Impedance Tomography (EIT) is a powerful imaging technique with diverse applications, e.g., medical diagnosis, industrial monitoring, and environmental studies. The EIT inverse problem is about inferring the internal conductivity…

机器学习 · 计算机科学 2023-10-31 Derick Nganyu Tanyu , Jianfeng Ning , Andreas Hauptmann , Bangti Jin , Peter Maass

PET imaging is an invaluable tool in clinical settings as it captures the functional activity of both healthy anatomy and cancerous lesions. Developing automatic lesion segmentation methods for PET images is crucial since manual lesion…

图像与视频处理 · 电气工程与系统科学 2024-11-05 Tanya Gatsak , Kumar Abhishek , Hanene Ben Yedder , Saeid Asgari Taghanaki , Ghassan Hamarneh

Human readers can accurately count how many letters are in a word (e.g., 7 in ``buffalo''), remove a letter from a given position (e.g., ``bufflo'') or add a new one. The human brain of readers must have therefore learned to disentangle…

计算机视觉与模式识别 · 计算机科学 2024-12-17 Bruno Bianchi , Aakash Agrawal , Stanislas Dehaene , Emmanuel Chemla , Yair Lakretz

Recent advances in scanning tunneling and transmission electron microscopies (STM and STEM) have allowed routine generation of large volumes of imaging data containing information on the structure and functionality of materials. The…

无序系统与神经网络 · 物理学 2021-06-24 Maxim Ziatdinov , Chun Yin Wong , Sergei V. Kalinin

Karyotyping is of importance for detecting chromosomal aberrations in human disease. However, chromosomes easily appear curved in microscopic images, which prevents cytogeneticists from analyzing chromosome types. To address this issue, we…

计算机视觉与模式识别 · 计算机科学 2023-06-27 Jingxiong Li , Sunyi Zheng , Zhongyi Shui , Shichuan Zhang , Linyi Yang , Yuxuan Sun , Yunlong Zhang , Honglin Li , Yuanxin Ye , Peter M. A. van Ooijen , Kang Li , Lin Yang

The Cryo-EM 3D particle reconstruction is essential for identifying protein and uncover the biological mechanism of the macro-molecules. In this paper, we use Kam method for reconstruction. Kam method is \textit{ab-initio}, and it assumes…

定量方法 · 定量生物学 2019-06-21 Yin Xian

The growing role of data-driven approaches to scientific discovery has unveiled a large class of models that involve latent transformations with a rigid algebraic constraint. Three-dimensional molecule reconstruction in Cryo-Electron…

信息论 · 计算机科学 2019-06-04 Amelia Perry , Jonathan Weed , Afonso S. Bandeira , Philippe Rigollet , Amit Singer

While liquid crystals (LCs) have been extensively studied, obtaining a comprehensive nanoscale picture of their molecular organization remains challenging, as conventional techniques face an intrinsic trade-off between spatial and chemical…

Differentiating signals from the background in micrographs is a critical initial step for cryogenic electron microscopy (cryo-EM), yet it remains laborious due to low signal-to-noise ratio (SNR), the presence of contaminants and densely…

图像与视频处理 · 电气工程与系统科学 2025-09-30 Szu-Chi Chung , Po-Cheng Chou

Recent advances in imaging from celestial objects in astronomy visualized via optical and radio telescopes to atoms and molecules resolved via electron and probe microscopes are generating immense volumes of imaging data, containing…

数据分析、统计与概率 · 物理学 2021-04-22 Maxim Ziatdinov , Sergei Kalinin

We introduce a new rotationally invariant viewing angle classification method for identifying, among a large number of Cryo-EM projection images, similar views without prior knowledge of the molecule. Our rotationally invariant features are…

生物大分子 · 定量生物学 2014-03-19 Zhizhen Zhao , Amit Singer

Cryo-EM is a vital technique for determining 3D structure of biological molecules such as proteins and viruses. The cryo-EM reconstruction problem is challenging due to the high noise levels, the missing poses of particles, and the…

定量方法 · 定量生物学 2024-06-05 Larissa de Ruijter , Gabriele Cesa

Scanning transmission electron microscopy (STEM) has become the technique of choice for quantitative characterization of atomic structure of materials, where the minute displacements of atomic columns from high-symmetry positions can be…

材料科学 · 物理学 2021-10-05 Kevin M. Roccapriore , Nicole Creange , Maxim Ziatdinov , Sergei V. Kalinin

The use of deep learning to undertake shape analysis of the complexities of the human head holds great promise. However, there have traditionally been a number of barriers to accurate modelling, especially when operating on both a global…

In cryo-electron microscopy, accurate particle localization and classification are imperative. Recent deep learning solutions, though successful, require extensive training data sets. The protracted generation time of physics-based models,…

机器学习 · 计算机科学 2025-02-20 Pavol Harar , Lukas Herrmann , Philipp Grohs , David Haselbach
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