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We analyse prior risk factors for severe, critical or fatal courses of Covid-19 based on a retrospective cohort using claims data of the AOK Bayern. As our main methodological contribution, we avoid prior grouping and pre-selection of…

应用统计 · 统计学 2021-02-16 Roland Jucknewitz , Oliver Weidinger , Anja Schramm

Detection of rare variants by resequencing is important for the identification of individuals carrying disease variants. Rapid sequencing by new technologies enables low-cost resequencing of target regions, although it is still prohibitive…

基因组学 · 定量生物学 2009-09-03 Noam Shental , Amnon Amir , Or Zuk

This paper presents methods to choose individuals to test for infection during a pandemic such as COVID-19, characterized by high contagion and presence of asymptomatic carriers. The smart-testing ideas presented here are motivated by…

机器学习 · 计算机科学 2020-12-29 Yingfei Wang , Inbal Yahav , Balaji Padmanabhan

Fast testing can help mitigate the coronavirus disease 2019 (COVID-19) pandemic. Despite their accuracy for single sample analysis, infectious diseases diagnostic tools, like RT-PCR, require substantial resources to test large populations.…

定量方法 · 定量生物学 2020-04-08 Junan Zhu , Kristina Rivera , Dror Baron

Pooling specimens, a well-accepted sampling strategy in biomedical research, can be applied to reduce the cost of studying biomarkers. Even if the cost of a single assay is not a major restriction in evaluating biomarkers, pooling can be a…

应用统计 · 统计学 2012-03-01 Enrique F. Schisterman , Albert Vexler , Aijun Ye , Neil J. Perkins

There are many hard-to-reconcile numbers circulating concerning Covid-19. Using reports from random testing, the fatality ratio per infection is evaluated and used to extract further information on the actual fraction of infections and the…

种群与进化 · 定量生物学 2020-05-25 Allen Caldwell , Vasyl Hafych , Oliver SChulz , Lolian Shtembari

During the SARS-CoV-2 pandemic, polymerase chain reaction (PCR) and lateral flow device (LFD) tests were frequently deployed to detect the presence of SARS-CoV-2. Many of these tests were singleplex, and only tested for the presence of a…

应用统计 · 统计学 2024-09-02 Martyn Fyles , Christopher E. Overton , Tom Ward , Emma Bennett , Tom Fowler , Ian Hall

Accurate detection of infected individuals is one of the critical steps in stopping any pandemic. When the underlying infection rate of the disease is low, testing people in groups, instead of testing each individual in the population, can…

统计方法学 · 统计学 2021-10-07 Mingzhou Fan , Byung-Jun Yoon , Francis J. Alexander , Edward R. Dougherty , Xiaoning Qian

This paper considers the noisy group testing problem where among a large population of items some are defective. The goal is to identify all defective items by testing groups of items, with the minimum possible number of tests. The focus of…

信息论 · 计算机科学 2021-10-20 Esmaeil Karimi , Anoosheh Heidarzadeh , Krishna R. Narayanan , Alex Sprintson

Controlling the COVID-19 pandemic is an urgent global challenge. The rapid geographic spread of SARS-CoV-2 directly reflects the social structure. Before effective vaccines and treatments are widely available, we have to rely on…

物理与社会 · 物理学 2021-08-11 Karina I Mazzitello , Yi Jiang , Constancio M Arizmendi

We propose a compressed sensing-based testing approach with a practical measurement design and a tuning-free and noise-robust algorithm for detecting infected persons. Compressed sensing results can be used to provably detect a small number…

信息论 · 计算机科学 2023-05-15 Hendrik Bernd Petersen , Bubacarr Bah , Peter Jung

The principal goal of Group Testing (GT) is to identify a small subset of "defective" items from a large population, by grouping items into as few test pools as possible. The test outcome of a pool is positive if it contains at least one…

信息论 · 计算机科学 2020-08-13 Alejandro Cohen , Asaf Cohen , Omer Gurewitz

High-dimensional group inference is an essential part of statistical methods for analysing complex data sets, including hierarchical testing, tests of interaction, detection of heterogeneous treatment effects and inference for local…

统计方法学 · 统计学 2020-12-01 Zijian Guo , Claude Renaux , Peter Bühlmann , T. Tony Cai

Pooled testing is widely used for screening for viral or bacterial infections with low prevalence when individual testing is not cost-efficient. Pooled testing with qualitative assays that give binary results has been well-studied. However,…

统计方法学 · 统计学 2020-11-03 Tao Liu , Joseph W Hogan , Wanning Su , Yizhen Xu , Michael J Daniels , Kantor Rami

Distinguishing COVID-19 from other flu-like illnesses can be difficult due to ambiguous symptoms and still an initial experience of doctors. Whereas, it is crucial to filter out those sick patients who do not need to be tested for…

The outbreak of the novel coronavirus (COVID-19) is unfolding as a major international crisis whose influence extends to every aspect of our daily lives. Effective testing allows infected individuals to be quarantined, thus reducing the…

机器学习 · 计算机科学 2020-07-28 Rahul Singh , Fang Liu , Ness B. Shroff

Combinatorial group testing (CGT) is used to identify defective items from a set of items by grouping them together and performing a small number of tests on the groups. Recently, group testing has been used to design efficient COVID-19…

离散数学 · 计算机科学 2022-11-02 Thais Bardini Idalino , Lucia Moura

For testing the statistical significance of a treatment effect, we usually compare between two parts of a population, one is exposed to the treatment, and the other is not exposed to it. Standard parametric and nonparametric two-sample…

统计计算 · 统计学 2012-11-02 Bikram Karmakar , Kumaresh Dhara , Kushal Kumar Dey , Analabha Basu , Anil Ghosh

Randomization tests are a popular method for testing causal effects in clinical trials with finite-sample validity. In the presence of heterogeneous treatment effects, it is often of interest to select a subgroup that benefits from the…

统计方法学 · 统计学 2025-04-29 Zijun Gao

The paper is focused on the problem of estimating the probability $p$ of individual contaminated sample, under group testing. The precision of the estimator is given by the probability of proportional closeness, a concept defined in the…

统计理论 · 数学 2017-12-27 Yaakov Malinovsky , Shelemyahu Zacks