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Infectious disease spread is a multi-scale process composed of within-host (biological) and between-host (social) drivers and disentangling them from each other is a central challenge in epidemiology. Here, we introduce VIBES, a multi-scale…

Accurate forecasts for COVID-19 are necessary for better preparedness and resource management. Specifically, deciding the response over months or several months requires accurate long-term forecasts which is particularly challenging as the…

种群与进化 · 定量生物学 2020-07-10 Ajitesh Srivastava , Viktor K. Prasanna

In this paper we propose a data-driven model for the spread of SARS-CoV-2 and use it to design optimal control strategies of human-mobility restrictions that both curb the epidemic and minimize the economic costs associated with…

最优化与控制 · 数学 2021-05-21 Mikhail Hayhoe , Francisco Barreras , Victor M. Preciado

The question of how SARS-CoV-2 is transmitted remains surprisingly controversial today, especially with reference to airborne transmission. In fact, despite a large body of scientific evidence, health and regulatory authorities still…

医学物理 · 物理学 2021-10-07 G. Buonanno , A. Robotto , E. Brizio , L. Morawska , A. Civra , F. Corino , D. Lembo , G. Ficco , L. Stabile

We estimate the reduction in transmission of SARS-CoV-2 achievable by surveillance testing of a susceptible population at different frequencies, comparing the cases of both the original Wuhan strain and the Delta variant. We estimate the…

物理与社会 · 物理学 2021-10-04 Ahmed Elbanna , Nigel Goldenfeld

Susceptible-Invective-Recovered (SIR) mathematical models are in high demand due to the COVID-19 pandemic. They are used in their standard formulation, or through the many variants, trying to fit and hopefully predict the number of new…

种群与进化 · 定量生物学 2020-05-19 Ben-Hur Francisco Cardoso , Sebastián Gonçalves

The COVID-19 pandemic response relied heavily on statistical and machine learning models to predict key outcomes such as case prevalence and fatality rates. These predictions were instrumental in enabling timely public health interventions…

A plethora of prediction models of SARS-CoV-2 pandemic were proposed in the past. Prediction performances not only depend on the structure and features of the model, but also on its parametrization. Official databases are often biased due…

种群与进化 · 定量生物学 2021-09-27 Yuri Kheifetz , Holger Kirsten , Markus Scholz

In observational studies with survival or time-to-event outcomes, a propensity score weighted marginal Cox proportional hazard model with the treatment variable as the only predictor is commonly used to estimate the causal marginal hazard…

统计方法学 · 统计学 2026-02-02 Zixian Zhao , Chengxin Yang , Fan Li

Methicillin-resistant Staphylococcus aureus (MRSA) is a critical public health threat within hospitals as well as long-term care facilities. Better understanding of MRSA risks, evaluation of interventions and forecasting MRSA rates are…

机器学习 · 计算机科学 2025-08-20 Rituparna Datta , Jiaming Cui , Gregory R. Madden , Anil Vullikanti

Health-policy planning requires evidence on the burden that epidemics place on healthcare systems. Multiple, often dependent, datasets provide a noisy and fragmented signal from the unobserved epidemic process including transmission and…

应用统计 · 统计学 2024-09-11 Alice Corbella , Anne M Presanis , Paul J Birrell , Daniela De Angelis

The COVID-19 pandemic has significantly challenged traditional epidemiological models due to factors such as delayed diagnosis, asymptomatic transmission, isolation-induced contact changes, and underreported mortality. In response to these…

应用统计 · 统计学 2025-03-10 Wenchen Liu , Chang Liu , Dehui Wang , Yiyuan She

In settings where most deaths occur outside the healthcare system, verbal autopsies (VAs) are a common tool to monitor trends in causes of death (COD). VAs are interviews with a surviving caregiver or relative that are used to predict the…

计算与语言 · 计算机科学 2024-04-04 Shuxian Fan , Adam Visokay , Kentaro Hoffman , Stephen Salerno , Li Liu , Jeffrey T. Leek , Tyler H. McCormick

Respondent-Driven Sampling (RDS) is an approach to sampling design and inference in hard-to-reach human populations. Typically, a sampling frame is not available, and population members are difficult to identify or recruit from broader…

统计方法学 · 统计学 2012-09-28 Mark S. Handcock , Krista J. Gile , Corinne M. Mar

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

Respondent-driven sampling is a form of link-tracing network sampling, which is widely used to study hard-to-reach populations, often to estimate population proportions. Previous treatments of this process have used a with-replacement…

统计方法学 · 统计学 2010-06-25 Krista J. Gile

Respondent-driven sampling (RDS) is a link-tracing network sampling strategy for collecting data from hard-to-reach populations, such as injection drug users or individuals at high risk of being infected with HIV. The mechanism is to find…

统计计算 · 统计学 2012-10-24 Sergiy Nesterko , Joseph Blitzstein

The adoption of prophylaxis attitudes, such as social isolation and use of face masks, to mitigate epidemic outbreaks strongly depends on the support of the population. In this work, we investigate a susceptible-infected-recovered (SIR)…

物理与社会 · 物理学 2022-10-05 Diogo H. Silva , Celia Anteneodo , Silvio C. Ferreira

Since 1927, until recently, models describing the spread of disease have mostly been of the SIR-compartmental type, based on the assumption that populations are homogeneous and well-mixed. The focus of these models have typically been on…

物理与社会 · 物理学 2014-07-23 Lara Goscé , David A W Barton , Anders Johansson

This paper develops an individual-based stochastic network SIR model for the empirical analysis of the Covid-19 pandemic. It derives moment conditions for the number of infected and active cases for single as well as multigroup epidemic…

计量经济学 · 经济学 2022-01-05 M. Hashem Pesaran , Cynthia Fan Yang