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Tracking single molecules is instrumental for quantifying the transport of molecules and nanoparticles in biological samples, e.g., in brain drug delivery studies. Existing intensity-based localisation methods are not developed for imaging…

Among the approaches in three-dimensional (3D) single molecule localization microscopy, there are several point spread function (PSF) engineering approaches, in which depth information of molecules is encoded in 2D images. Usually,the…

光学 · 物理学 2024-07-11 Hanzhe Wu , Danni Chen , YiHong Jiand Gan Xiang , Heng Li , Bin Yu , JunLe Qu

Super-resolution imaging based on single molecule localization allows accessing nanometric-scale information in biological samples with high precision. However, complete measurements including molecule orientation are still challenging.…

We utilize the localization analysis method to precisely determine the light beam positions with the spatial separation beyond the optical diffraction limit. By such a direct spatial measurement, the associated optical setup is built to…

仪器与探测器 · 物理学 2018-10-11 Hoi Chun Chiu , Zhuohui Zeng , Luwei Zhao , Teng Zhao , Shengwang Du , Xian Chen

The paper proposes a method of finding the beam loss locations in a linac. If the beam is scraped at an aperture limitation, moving its centroid with two dipole correctors located upstream and oscillating in sync produces a line at the…

加速器物理 · 物理学 2019-05-02 Alexander Shemyakin

Single-emitter microscopy has emerged as a promising method of imaging nanostructures with nanoscale resolution. This technique uses the centroid position of an emitters far-field radiation pattern to infer its position to a precision that…

光学 · 物理学 2016-11-03 Kangmook Lim , Chad Ropp , John Fourkas , Benjamin Shapiro , Edo Waks

Context. Anomalous microwave emission (AME) is a component of interstellar medium emission peaking at 10-60 GHz. Its polarization is both a CMB foreground and a probe of the alignment physics of very small dust grains. Aims. We quantify…

星系天体物理 · 物理学 2026-04-30 Boy Lankhaar

This paper derives a general expression for the Cram\'er-Rao bound (CRB) of wireless localization algorithms using range measurements subject to bias corruption. Specifically, the a priori knowledge about which range measurements are…

信息论 · 计算机科学 2011-11-10 Tao Wang

Scalar optically-pumped magnetometers (OPMs) are being developed in small packages with high sensitivities. The high common-mode rejection ratio of these sensors allows for detection of very small signals in the presence of large background…

仪器与探测器 · 物理学 2021-09-17 Richard J. Clancy , Vladislav Gerginov , Orang Alem , Stephen Becker , Svenja Knappe

Aims. We investigate the maximum astrometric precision that can be reached on moving targets observed with digital-sensor arrays, and provide an estimate for its ultimate lower limit based on the Cram\'er-Rao bound. Methods. We extend…

天体物理仪器与方法 · 物理学 2017-10-04 S. Bouquillon , R. A. Mendez , M. Altmann , T. Carlucci , C. Barache , F. Taris , A. H. Andrei , R. Smart

In this paper, we show that it is possible to overcome one of the fundamental limitations of super-resolution microscopy techniques: the necessity to be in an \emph{optically homogeneous} environment. Using recent modal approximation…

偏微分方程分析 · 数学 2022-07-14 Lorenzo Baldassari , Alice L. Vanel , Pierre Millien

In modern radar systems, precise target localization using azimuth and velocity estimation is paramount. Traditional unbiased estimation methods have utilized gradient descent algorithms to reach the theoretical limits of the Cramer Rao…

信号处理 · 电气工程与系统科学 2024-04-24 Shyam Venkatasubramanian , Sandeep Gogineni , Bosung Kang , Muralidhar Rangaswamy

Polar molecules are desirable systems for quantum simulations and cold chemistry. Molecular ions are easily trapped, but a bias electric field applied to polarize them tends to accelerate them out of the trap. We present a general solution…

Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

应用物理 · 物理学 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

We establish the multiparameter quantum Cram\'er-Rao bound for simultaneously estimating the centroid, the separation, and the relative intensities of two incoherent optical point sources using alinear imaging system. For equally bright…

量子物理 · 物理学 2017-12-13 J. Rehacek , Z. Hradil , B. Stoklasa , M. Paur , J. Grover , A. Krzic , L. L. Sanchez-Soto

Various techniques have been developed to measure the 2D and 3D positions and 2D and 3D orientations of fluorescent molecules with improved precision over standard epifluorescence microscopes. Due to the challenging signal-to-background…

光学 · 物理学 2021-02-02 Oumeng Zhang , Matthew D. Lew

We demonstrate an approach to obtaining near quantum-limited far-field imaging resolution of incoherent sources with arbitrary distributions. Our method assumes no prior knowledge of the source distribution, but rather uses an adaptive…

量子物理 · 物理学 2022-02-28 Erik F. Matlin , Lucas J. Zipp

The use of differential phase contrast (DPC) in scanning transmission electron microscopy (STEM) has shown much promise for directly investigating the functional properties of a material system, leveraging the natural coupling between the…

材料科学 · 物理学 2025-12-04 Rafael V. Ferreira , Sebastian Calderon V. , Paulo J. Ferreira

Fluorescence microscopy is essential in biological and medical research, providing critical insights into cellular structures. However, limited by optical diffraction and background noise, a substantial amount of hidden information is still…

生物物理 · 物理学 2026-04-14 Xiaofeng Zhang , Yongsheng Huang , Jielong Yang , Zhili Wang , Si Chen , Linbo Liu , Xin Ge

The adoption of large-scale antenna arrays at high-frequency bands is widely envisioned in the beyond 5G wireless networks. This leads to the near-field regime where the wavefront is no longer planar but spherical, bringing new…

信号处理 · 电气工程与系统科学 2023-06-28 Ang Chen , Li Chen , Yunfei Chen , Changsheng You , Guo Wei , F. Richard Yu