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Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes \textit{extracellular} process elements such as the bioreactor design and mode of operation,…

系统与控制 · 电气工程与系统科学 2023-02-07 Sebastián Espinel-Ríos , Bruno Morabito , Johannes Pohlodek , Katja Bettenbrock , Steffen Klamt , Rolf Findeisen

Numerous challenges in science and engineering can be framed as optimization tasks, including the maximization of reaction yields, the optimization of molecular and materials properties, and the fine-tuning of automated hardware protocols.…

最优化与控制 · 数学 2021-11-19 Matteo Aldeghi , Florian Häse , Riley J. Hickman , Isaac Tamblyn , Alán Aspuru-Guzik

This paper proposes a model-based optimization method for the production of automotive seals in an extrusion process. The high production throughput, coupled with quality constraints and the inherent uncertainty of the process, encourages…

系统与控制 · 电气工程与系统科学 2024-10-31 Raul Cruz-Oliver , Luis Monzon , Edgar Ramirez-Laboreo , Jose-Manuel Rodriguez-Fortun

Robustness to natural distribution shifts has seen remarkable progress thanks to recent pre-training strategies combined with better fine-tuning methods. However, such fine-tuning assumes access to large amounts of labelled data, and the…

计算机视觉与模式识别 · 计算机科学 2023-09-26 Aaditya Singh , Kartik Sarangmath , Prithvijit Chattopadhyay , Judy Hoffman

According to recent results, convergence in a prespecified or prescribed finite time can be achieved under extreme model uncertainty if control is applied continuously over time. This paper shows that this extreme amount of uncertainty…

系统与控制 · 电气工程与系统科学 2023-06-27 Hernan Haimovich , Rodrigo Aldana-Lopez , Richard Seeber , David Gomez-Gutierrez

Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the…

分子网络 · 定量生物学 2012-03-28 Jost Neigenfind , Sergio Grimbs , Zoran Nikoloski

Optimization of expensive computer models with the help of Gaussian process emulators in now commonplace. However, when several (competing) objectives are considered, choosing an appropriate sampling strategy remains an open question. We…

最优化与控制 · 数学 2013-10-03 Victor Picheny

Optimal design of experiments for Bayesian inverse problems has recently gained wide popularity and attracted much attention, especially in the computational science and Bayesian inversion communities. An optimal design maximizes a…

最优化与控制 · 数学 2023-05-09 Ahmed Attia , Sven Leyffer , Todd Munson

Radiotherapy treatment planning is a challenging large-scale optimization problem plagued by uncertainty. Following the robust optimization methodology, we propose a novel, spatially based uncertainty set for robust modeling of radiotherapy…

最优化与控制 · 数学 2024-05-28 Noam Goldberg , Mark P. Langer , Shimrit Shtern

This paper considers the problem of online feedback optimization to solve the AC Optimal Power Flow in real-time in power grids. This consists in continuously driving the controllable power injections and loads towards the optimal…

系统与控制 · 电气工程与系统科学 2021-11-18 Miguel Picallo , Saverio Bolognani , Florian Dörfler

In this paper, we solve the multiple product price optimization problem under interval uncertainties of the price sensitivity parameters in the demand function. The objective of the price optimization problem is to maximize the overall…

最优化与控制 · 数学 2021-07-01 Mahdi Hamzeei , Alvin Lim , Jiefeng Xu

Insufficient performance of optimization approaches for fitting of mathematical models is still a major bottleneck in systems biology. In this manuscript, the reasons and methodological challenges are summarized as well as their impact in…

性能 · 计算机科学 2019-07-09 Clemens Kreutz

The control of manufacturing processes must satisfy high quality and efficiency requirements while meeting safety requirements. A broad spectrum of monitoring and control strategies, such as model- and optimization-based controllers, are…

系统与控制 · 电气工程与系统科学 2023-01-18 Andreas Himmel , Janine Matschek , Rudolph Kok , Bruno Morabito , Hoang Hai Nguyen , Rolf Findeisen

Non-prehensile manipulation such as pushing is typically subject to uncertain, non-smooth dynamics. However, modeling the uncertainty of the dynamics typically results in intractable belief dynamics, making data-efficient planning under…

机器人学 · 计算机科学 2024-06-28 Julius Jankowski , Lara Brudermüller , Nick Hawes , Sylvain Calinon

Errors occurring on noisy hardware pose a key challenge to reliable quantum computing. Existing techniques such as error correction, mitigation, or suppression typically separate the error handling from the algorithm analysis and design. In…

量子物理 · 物理学 2026-01-21 Julian Berberich , Tobias Fellner , Robert L. Kosut , Christian Holm

We develop and analyze a method for stochastic simulation optimization based on Gaussian process models within a trust-region framework. We focus on settings where the variance of the objective function is large, making accurate estimation…

最优化与控制 · 数学 2026-03-10 Mickael Binois , Jeffrey Larson

Robustness is a basic property of any control system. In the context of linear output regulation, it was proved that embedding an internal model of the exogenous signals is necessary and sufficient to achieve tracking of the desired…

系统与控制 · 电气工程与系统科学 2021-04-23 Michelangelo Bin , Daniele Astolfi , Lorenzo Marconi

The scheme of online optimization as a feedback controller is widely used to steer the states of a physical system to the optimal solution of a predefined optimization problem. Such methods focus on regulating the physical states to the…

系统与控制 · 电气工程与系统科学 2025-08-05 Ming Li , Zhaojian Wang , Feng Liu , Ming Cao , Bo Yang

This paper presents a computational framework for the robust stiffness design of hyperelastic structures at finite deformations subject to various uncertain sources. In particular, the loading, material properties, and geometry…

计算工程、金融与科学 · 计算机科学 2025-01-28 Nan Feng , Guodong Zhang , Kapil Khandelwal

Long-term reservoir management often uses bounds on the reservoir level, between which the operator can work. However, these bounds are not always kept up-to-date with the latest knowledge about the reservoir drainage area, and thus become…

最优化与控制 · 数学 2018-01-29 Thibaut Cuvelier , Pierre Archambeau , Benjamin Dewals , Quentin Louveaux