相关论文: Inferring simple but precise quantitative models o…

In this working paper, I developed a suite of macroeconomic models that shed light on the intricate relationship between economic development, health, and fertility. These innovative models conceptualize health as an intermediate good,…

Accurate fetal birth weight prediction is a cornerstone of prenatal care, yet traditional methods often rely on imaging technologies that remain inaccessible in resource-limited settings. This study presents a novel machine learning-based…

Automating human preimplantation embryo grading offers the potential for higher success rates with in vitro fertilization (IVF) by providing new quantitative and objective measures of embryo quality. Current IVF procedures typically use…

The accurate modeling of biological processes allows to predict the spatio-temporal behavior of living tissues by computer-aided (in-silico) testing, a useful tool for the development of medical strategies, avoiding the expenses and…

In Vitro Fertilization (IVF) is the most widely used Assisted Reproductive Technology (ART). IVF usually involves controlled ovarian stimulation, oocyte retrieval, fertilization in the laboratory with subsequent embryo transfer. The first…

The developmental process of embryos follows a monotonic order. An embryo can progressively cleave from one cell to multiple cells and finally transform to morula and blastocyst. For time-lapse videos of embryos, most existing developmental…

In proliferating epithelia of mammalian skin, cells of irregular polygonal-like shapes pack into complex nearly flat two-dimensional structures that are pliable to deformations. In this work, we employ various sensitive correlation…

Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalogue…

In conventional clinical in-vitro fertilization practices embryos are transferred either at the cleavage or blastocyst stages of development. Cleavage stage transfers, particularly, are beneficial for patients with relatively poor prognosis…

Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of…

The segregation and integration of infant brain networks undergo tremendous changes due to the rapid development of brain function and organization. Traditional methods for estimating brain modularity usually rely on group-averaged…

In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood…

Statistical and computational methods are widely used in today's scientific studies. Using a female fertility potential in childhood cancer survivors as an example, we illustrate how these methods can be used to extract insight regarding…

A key process in the life of any multicellular organism is its development from a single egg into a full grown adult. The first step in this process often consists of forming a tissue layer out of randomly placed cells on the surface of the…

In vitro fertilization (IVF) is a widely utilized assisted reproductive technology, yet predicting its success remains challenging due to the multifaceted interplay of clinical, demographic, and procedural factors. This study develops a…

Density dependence is important in the ecology and evolution of microbial and cancer cells. Typically, we can only measure net growth rates, but the underlying density-dependent mechanisms that give rise to the observed dynamics can…

Understanding how human health changes over time, and why responses to interventions vary between individuals, remains a central challenge in medicine. Here we present HealthFormer, a decoder-only transformer that models the human…

Visual observation of Cumulus Oocyte Complexes provides only limited information about its functional competence, whereas the molecular evaluations methods are cumbersome or costly. Image analysis of mammalian oocytes can provide attractive…

The growth, form, and division of prebiotic vesicles, membraneous bags of fluid of varying components and shapes is hypothesized to have served as the substrate for the origin of life. The dynamics of these out-of-equilibrium structures is…

"Self-organization" has become a watchword in developmental biology, characterizing observations in which embryonic or induced stem cells of animals replicate morphological steps and outcomes seen in intact embryos. While the term was…