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Two-sample hypothesis testing for network comparison presents many significant challenges, including: leveraging repeated network observations and known node registration, but without requiring them to operate; relaxing strong structural…

统计方法学 · 统计学 2024-02-05 Meijia Shao , Dong Xia , Yuan Zhang , Qiong Wu , Shuo Chen

Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing…

基因组学 · 定量生物学 2017-01-03 Haifeng Chen , Ting Chen

This paper presents hep-aid, a modular Python library conceived for utilising, implementing, and developing parameter scan algorithms. Originally devised for sample-efficient, multi-objective active search approaches in computationally…

高能物理 - 唯象学 · 物理学 2024-12-24 Mauricio A. Diaz , Srinandan Dasmahapatra , Stefano Moretti

Recently, parallel search engines have been implemented based on scalable distributed file systems such as Google File System. However, we claim that building a massively-parallel search engine using a parallel DBMS can be an attractive…

数据库 · 计算机科学 2012-08-22 Kyu-Young Whang , Tae-Seob Yun , Yeon-Mi Yeo , Il-Yeol Song , Hyuk-Yoon Kwon , In-Joong Kim

Subgraph isomorphism, essential for pattern detection in large-scale graphs, faces scalability challenges in attribute-rich property graphs used in neuroscience, systems biology, and social network analysis. Traditional algorithms explore…

数据结构与算法 · 计算机科学 2025-07-08 Mohammad Dindoost , Oliver Alvarado Rodriguez , Bartosz Bryg , Ioannis Koutis , David A. Bader

The near channel performance of Low Density Parity Check Codes (LDPC) has motivated its wide applications. Iterative decoding of LDPC codes provides significant implementation challenges as the complexity grows with the code size. Recent…

分布式、并行与集群计算 · 计算机科学 2022-11-29 Sudeep Kanur , Georgios Georgakarakos , Antti Siirilä , Jérémie Lagravière , Kristian Nybom , Sébastien Lafond , Johan Lilius

Numerous complex real-world systems, such as those in biological, ecological, and social networks, exhibit higher-order interactions that are often modeled using polynomial dynamical systems or homogeneous polynomial dynamical systems…

动力系统 · 数学 2025-03-25 Xin Mao , Anqi Dong , Ziqin He , Yidan Mei , Shenghan Mei , Can Chen

An important step in the task of neural network design, such as hyper-parameter optimization (HPO) or neural architecture search (NAS), is the evaluation of a candidate model's performance. Given fixed computational resources, one can…

机器学习 · 计算机科学 2021-03-09 Shengcao Cao , Xiaofang Wang , Kris Kitani

Metaproteomics has become a crucial omics technology for studying microbiomes. In this area, the Unipept ecosystem, accessible at https://unipept.ugent.be, has emerged as an invaluable resource for analyzing metaproteomic data. It offers…

Latent variable models have accumulated a considerable amount of interest from the industry and academia for their versatility in a wide range of applications. A large amount of effort has been made to develop systems that is able to extend…

机器学习 · 计算机科学 2015-11-19 Aaron Q. Li , Amr Ahmed , Mu Li , Vanja Josifovski

I/O efficiency is crucial to productivity in scientific computing, but the increasing complexity of the system and the applications makes it difficult for practitioners to understand and optimize I/O behavior at scale. Data-driven machine…

Mining large-scale high-throughput tandem mass spectrometry data sets is a very important problem in mass spectrometry based protein identification. One of the fundamental problems in large scale mining of spectra is to design appropriate…

定量方法 · 定量生物学 2007-05-23 Debojyoti Dutta , Ting Chen

Exponential increases in scientific experimental data are outstripping the rate of progress in silicon technology. As a result, heterogeneous combinations of architectures and process or device technologies are increasingly important to…

分布式、并行与集群计算 · 计算机科学 2024-07-02 Wilkie Olin-Ammentorp , Xingfu Wu , Andrew A. Chien

Real-time image segmentation demands architectures that preserve fine spatial detail while capturing global context under tight latency and memory budgets. Image segmentation is one of the most fundamental problems in computer vision and…

计算机视觉与模式识别 · 计算机科学 2025-11-11 Hongyuan Yu , Cheng Wan , Xiyang Dai , Mengchen Liu , Dongdong Chen , Bin Xiao , Yan Huang , Yuan Lu , Liang Wang

Modern day computing increasingly relies on specialization to satiate growing performance and efficiency requirements. A core challenge in designing such specialized hardware architectures is how to perform mapping space search, i.e.,…

机器学习 · 计算机科学 2021-03-03 Kartik Hegde , Po-An Tsai , Sitao Huang , Vikas Chandra , Angshuman Parashar , Christopher W. Fletcher

Data series similarity search is a core operation for several data series analysis applications across many different domains. However, the state-of-the-art techniques fail to deliver the time performance required for interactive…

数据库 · 计算机科学 2021-10-15 Botao Peng , Panagiota Fatourou , Themis Palpanas

Dataset condensation can be used to reduce the computational cost of training multiple models on a large dataset by condensing the training dataset into a small synthetic set. State-of-the-art approaches rely on matching the model gradients…

High-throughput sequencing (HTS) technologies have revolutionized the field of genomics, enabling rapid and cost-effective genome analysis for various applications. However, the increasing volume of genomic data generated by HTS…

硬件体系结构 · 计算机科学 2023-06-01 Onur Mutlu , Can Firtina

Single-cell proteomics (SCP) is transforming our understanding of biological complexity by shifting from bulk proteomics, where signals are averaged over thousands of cells, to the proteome analysis of individual cells. This granular…

定量方法 · 定量生物学 2025-04-01 Amanda Momenzadeh , Jesse G. Meyer