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We seek to identify genes involved in Parkinson's Disease (PD) by combining information across different experiment types. Each experiment, taken individually, may contain too little information to distinguish some important genes from…

Current diagnosis and prognosis for Parkinson's disease (PD) face formidable challenges due to the heterogeneous nature of the disease course, including that (i) the impairment severity varies hugely between patients, (ii) whether a symptom…

应用统计 · 统计学 2024-10-03 Kai Kang , Yuqi Gu

Parkinson's disease is a progressive and slowly developing neurodegenerative disease, characterized by dopaminergic neuron loss in the substantia nigra region of the brain. Despite extensive research by scientists, there is not yet a cure…

定量方法 · 定量生物学 2024-08-31 Pratham Kankariya , Rachita Rode , Kevin Mudaliar , Pranali Hatode

In recent years, there are many research cases for the diagnosis of Parkinson's disease (PD) with the brain magnetic resonance imaging (MRI) by utilizing the traditional unsupervised machine learning methods and the supervised deep learning…

图像与视频处理 · 电气工程与系统科学 2020-03-11 Xiaobo Zhang , Donghai Zhai , Yan Yang , Yiling Zhang , Chunlin Wang

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…

In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during…

机器学习 · 计算机科学 2018-02-20 Claudio Gallicchio , Alessio Micheli , Luca Pedrelli

Brain-computer interfaces are being explored for a wide variety of therapeutic applications. Typically, this involves measuring and analyzing continuous-time electrical brain activity via techniques such as electrocorticogram (ECoG) or…

神经与进化计算 · 计算机科学 2023-04-28 Yiming Ai , Bipin Rajendran

In recent years, applications of data mining methods are become more popular in many fields of medical diagnosis and evaluations. The data mining methods are appropriate tools for discovering and extracting of available knowledge in medical…

计算工程、金融与科学 · 计算机科学 2013-12-10 Peyman Mohammadi , Abdolreza Hatamlou , Mohammad Masdari

Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution…

机器学习 · 计算机科学 2020-10-16 Weijian Li , Wei Zhu , E. Ray Dorsey , Jiebo Luo

In this paper, we envision a web-based framework that can help anyone, anywhere around the world record a short speech task, and analyze the recorded data to screen for Parkinson's disease (PD). We collected data from 726 unique…

The current body of research on Parkinson's disease (PD) screening, monitoring, and management has evolved along two largely independent trajectories. The first research community focuses on multimodal sensing of PD-related biomarkers using…

信号处理 · 电气工程与系统科学 2025-11-11 Hassan Hizeh , Rim Chighri , Muhammad Mahboob Ur Rahman , Mohamed A. Bahloul , Ali Muqaibel , Tareq Y. Al-Naffouri

The automatic identification of medication states of Parkinson's disease (PD) patients can assist clinicians in monitoring and scheduling personalized treatments, as well as studying the effects of medication in alleviating the motor…

Parkinson's disease (PD) is a slowly progressive, debilitating neurodegenerative disease which causes motor symptoms including gait dysfunction. Motor fluctuations are alterations between periods with a positive response to levodopa therapy…

信号处理 · 电气工程与系统科学 2023-08-07 Ferdian Jovan , Catherine Morgan , Ryan McConville , Emma L. Tonkin , Ian Craddock , Alan Whone

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant…

计算机视觉与模式识别 · 计算机科学 2026-03-12 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough to interfere with daily life. Currently,…

计算机视觉与模式识别 · 计算机科学 2024-05-28 Tiziana D'Alessandro , Cristina Carmona-Duarte , Claudio De Stefano , Moises Diaz , Miguel A. Ferrer , Francesco Fontanella

Labeled speech data from patients with Parkinsons disease (PD) are scarce, and the statistical distributions of training and test data differ significantly in the existing datasets. To solve these problems, dimensional reduction and sample…

机器学习 · 计算机科学 2020-02-11 Xiaoheng Zhang , Yongming Li , Pin Wang , Xiaoheng Tan , Yuchuan Liu

Parkinson's disease (PD) is a neurodegenerative disorder characterized by increased response times leading to a variety of biomechanical symptoms such as tremors, stooping and gait instability. Although the deterioration in biomechanical…

定量方法 · 定量生物学 2017-07-27 Vrutangkumar Shah , Sachin Goyal , Harish Palanthandalam-Madapusi

Parkinson's Disease(PD) is one of the major nervous system disorders that affect people over 60. PD can cause cognitive impairments. In this work, we explore various approaches to identify Parkinson's using Magnetic Resonance (MR) T1 images…

图像与视频处理 · 电气工程与系统科学 2020-07-03 Tahjid Ashfaque Mostafa , Irene Cheng

Parkinsons disease, the fastest growing neurodegenerative disorder globally, has seen a 50 percent increase in cases within just two years. As speech, memory, and motor symptoms worsen over time, early diagnosis is crucial for preserving…

定量方法 · 定量生物学 2024-12-02 Diya Vatsavai , Anya Iyer , Ashwin A. Nair