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The Large Binocular Telescope (LBT) is a unique telescope featuring two co-mounted optical trains with 8.4m primary mirrors. The telescope Adaptive Optics (AO) system uses two innovative key components, namely an adaptive secondary mirror…
Robotic automation has transformed scientific workflows in domains such as chemistry and materials science, yet free-space optics, which is a high precision domain, remains largely manual. Optical systems impose strict spatial and angular…
Diabetic Retinopathy is the leading cause of blindness in the world. At least 90\% of new cases can be reduced with proper treatment and monitoring of the eyes. However, scanning the entire population of patients is a difficult endeavor.…
Despite the recent advances in augmented reality (AR), which has shown the potential to significantly impact on our daily lives by offering a new way to manipulate and interact with virtual information, minimizing visual discomfort due to…
Purpose: Eye morphology varies significantly across the population, especially for the orbit and optic nerve. These variations limit the feasibility and robustness of generalizing population-wise features of eye organs to an unbiased…
Optical focusing through/inside scattering media, like multimode fiber and biological tissues, has significant impact in biomedicine yet considered challenging due to strong scattering nature of light. Previously, promising progress has…
Many present and future accelerators must operate with high intensity beams when distortions induced by space charge forces are among major limiting factors. Betatron tune depression of above approximately 0.1 per cell leads to significant…
People with blindness and low vision (pBLV) experience significant challenges when locating final destinations or targeting specific objects in unfamiliar environments. Furthermore, besides initially locating and orienting oneself to a…
We describe results from the first astronomical adaptive optics system to use multiple laser guide stars, located at the 6.5-m MMT telescope in Arizona. Its initial operational mode, ground-layer adaptive optics (GLAO), provides uniform…
Eye lens dosimetry has been an important field of research in the last decade. Dose measurements with a prototype of an active personal eye lens dosemeter based on the Dosepix detector are presented. The personal dose equivalent at $3\,$mm…
Precise lens structure segmentation is essential for the design of intraocular lenses (IOLs) in cataract surgery. Existing deep segmentation networks typically weight all pixels equally under cross-entropy (CE) loss, overlooking the fact…
BACKGROUND: Proptosis is characterized by a protrusion of the eyeball due to an increase of the orbital tissue volume. To recover a normal eyeball positioning, the most frequent surgical technique consists in the osteotomy of orbital walls…
The joint interpretation of multi-modal and multi-view fundus images is critical for retinopathy prevention, as different views can show the complete 3D eyeball field and different modalities can provide complementary lesion areas. Compared…
Age-related Macular Degeneration (AMD) is a progressive visual impairment affecting millions of individuals. Since there is no current treatment for the disease, the only means of improving the lives of individuals suffering from the…
Near-diffraction limited imaging and spectroscopy in the visible on large (8-10 meter) class telescopes has proved to be beyond the capabilities of current adaptive optics technologies, even when using laser guide stars. The need for high…
One important frontier for astronomical adaptive optics (AO) involves methods such as Multi-Object AO and Multi-Conjugate AO that have the potential to give a significantly larger field of view than conventional AO techniques. A second key…
Mass-produced optical lenses often exhibit defects that alter their scattering properties and compromise quality standards. Manual inspection is usually adopted to detect defects, but it is not recommended due to low accuracy, high error…
Recent Alzheimer's disease (AD) patient studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. However as this is a relatively new…
Object hallucination in Large Vision-Language Models (LVLMs) severely compromises their reliability in real-world applications, posing a critical barrier to their deployment in high-stakes scenarios such as autonomous driving and medical…
While the existence of an asymmetry between the two Maxwell centroids at the centre of the two foveas recorded using a foveascope, leads to the ocular dominance in good readers, the lack of asymmetry in most of the observers with dyslexia…