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Cell-cell contacts in tissues are continuously subject to mechanical forces due to homeostatic pressure and active cytoskeleton dynamics. While much is known about the molecular pathways of adhesion, the role of mechanics is less well…

生物物理 · 物理学 2015-06-04 Lea-Laetitia Pontani , Ivane Jorjadze , Virgile Viasnoff , Jasna Brujic

Animal morphogenesis involves complex tissue deformation processes, which require tight control over tissue rheology. Yet, it remains insufficiently understood how tissue rheology results from the interplay between cellular packing and…

We study the elasto-plastic behavior of dense attractive emulsions under mechanical perturbation. The attraction is introduced through non-specific depletion interactions between the droplets and is controlled by changing the concentration…

During the development of an organism, cells must coordinate and organize to generate the correct shape, structure, and spatial patterns of tissues and organs, a process known as morphogenesis. The morphogenesis of embryonic tissues is…

组织与器官 · 定量生物学 2026-04-28 Adrian Aguirre-Tamaral , Elisa Floris , Bernat Corominas-Murtra

The nature of adhesion of droplets to surfaces is a long pending scientific question. With the evolution of complex surfaces, quantification and prediction of these forces become intricate. Nevertheless, understanding these forces is highly…

软凝聚态物质 · 物理学 2021-10-14 David Feldmann , Bat-El Pinchasik

The behaviour and fate of tissue cells is controlled by the rigidity and geometry of their adhesive environment, possibly through forces localized to sites of adhesion. We introduce a mechanical model that predicts cellular force…

细胞行为 · 定量生物学 2009-07-24 Ilka B. Bischofs , Sebastian S. Schmidt , Ulrich S. Schwarz

Understanding contact line dynamics on superhydrophobic surfaces with microscopic structures is essential for designing materials with reduced drag, anti-icing, self-cleaning, and anti-fouling properties. Using numerical simulations, we…

流体动力学 · 物理学 2025-11-27 Pawan Kumar , Marta Krasowska , Joseph D. Berry

Soft particles can be better emulsifiers than hard particles because they stretch at fluid interfaces. This deformation can increase adsorption energies by orders of magnitude relative to rigid particles. The deformation of a particle at an…

软凝聚态物质 · 物理学 2015-07-15 Robert W. Style , Lucio Isa , Eric R. Dufresne

Adhesive cell-substrate interactions are crucial for cell motility and are responsible for the necessary traction that propels cells. These interactions can also change the shape of the cell, analogous to liquid droplet wetting on adhesive…

Cellular rearrangements, as primary sources of tissue fluidization, facilitate topological transitions during tissue morphogenesis. We study the role of intrinsic cell properties such as cell polarity and cell-cell adhesion in shaping…

生物物理 · 物理学 2024-03-11 Richard D. J. G. Ho , Stig Ove Bøe , Dag Kristian Dysthe , Luiza Angheluta

The size and shape of a large variety of polymeric particles, including biological cells, star polymers, dendrimes, and microgels, depend on the applied stresses as the particles are extremely soft. In high-density suspensions these…

统计力学 · 物理学 2018-04-11 Yan-Wei Li , Massimo Pica Ciamarra

We study the self-assembly of colloidal microgel particles at a quasi-two-dimensional air-water interface of a drying droplet. Using bright-field microscopy, we demonstrate that increasing particle elasticity drives interfacial organization…

软凝聚态物质 · 物理学 2026-03-10 Vaibhav Raj Singh Parmar , Sayantan Chanda , Rituparno Mandal , Ranjini Bandyopadhyay

One of the most unique physical features of cell adhesion to external surfaces is the active generation of mechanical force at the cell-material interface. This includes pulling forces generated by contractile polymer bundles and networks,…

细胞行为 · 定量生物学 2013-09-12 Ulrich S. Schwarz , Samuel S. Safran

Biological cells use droplets to separate components and spatially control their interior. Experiments demonstrate that the complex, crowded cellular environment affects the droplet arrangement and their sizes. To understand this behavior,…

软凝聚态物质 · 物理学 2021-10-27 Estefania Vidal-Henriquez , David Zwicker

When a free-falling liquid droplet is hit by a laser it experiences a strong ablation driven pressure pulse. Here we study the resulting droplet deformation in the regime where the ablation pressure duration is short, i.e. comparable to the…

流体动力学 · 物理学 2017-10-11 Sten A. Reijers , Jacco H. Snoeijer , Hanneke Gelderblom

Drying a droplet of colloidal dispersion can result in complex pattern formation due to both development and deformation of a skin at the drop surface. The present study focus on the drying process of droplets of colloidal dispersions in a…

软凝聚态物质 · 物理学 2012-11-08 François Boulogne , Frédérique Giorgiutti-Dauphiné , Ludovic Pauchard

Cell migration plays a fundamental role in numerous physiological processes, including embryonic development, wound healing, and cancer metastasis. While cell-cell adhesion is known to regulate motion by shaping cell morphology and…

生物物理 · 物理学 2026-03-09 Anh Q. Nguyen , Pradip K. Bera , Jacob Notbohm , Dapeng Bi

Connecting cell behavior to tissue shape and mechanics is a key challenge in the physics of morphogenesis. Cytoskeletal turnover precludes a fixed reference state, and tensions are actively generated independently of strain; so conventional…

软凝聚态物质 · 物理学 2026-05-28 Nikolas H. Claussen , Fridtjof Brauns , Boris I. Shraiman

Pathogens in droplets on fomites and aerosols go through extreme physiochemical conditions, such as confinement and osmotic stress, due to evaporation. Still, these droplets are the predominant transmission routes of many contagious…

软凝聚态物质 · 物理学 2021-08-10 Maheshwar Gopu , Akanksha Agrawal , Raju Mukherjee , Dileep Mampallil

The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in…

生物物理 · 物理学 2018-04-25 Katsuyoshi Matsushita
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