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The minimum possible value of the average deceleration of the head of a player engaged in an impact sport such as football or hockey, as a result of an impact of his/her helmet with a surface or another player, is inversely proportional to…

The following study is motivated by experimental studies in traumatic brain injury (TBI). Recent research has demonstrated that low intensity non-impact blast wave exposure frequently leads to mild traumatic brain injury (mTBI); however,…

The segmentation of lesions in Moderate to Severe Traumatic Brain Injury (msTBI) presents a significant challenge in neuroimaging due to the diverse characteristics of these lesions, which vary in size, shape, and distribution across brain…

Evaluating the causal effect of an intervention on multivariate outcomes is challenging when the outcomes are interdependent and derived rather than directly observed. Effective connectivity, which summarizes the directional neural…

Magnetoencephalography (MEG) scanner has been shown to be more accurate than other medical devices in detecting mild traumatic brain injury (mTBI). However, MEG scan data in certain spectrum ranges can be skewed, multimodal and…

There is increasing evidence on the importance of brain morphology in predicting and classifying mental disorders. However, the vast majority of current shape approaches rely heavily on vertex-wise analysis that may not successfully capture…

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…

Computer Tomography (CT) is the gold standard technique for brain damage evaluation after acute Traumatic Brain Injury (TBI). It allows identification of most lesion types and determines the need of surgical or alternative therapeutic…

The Ogden model is often considered as a standard model in the literature for application to the deformation of brain tissue. Here we show that, in some of those applications, the use of the Ogden model leads to non-convexity of the…

Lesion detection in brain Magnetic Resonance Images (MRI) remains a challenging task. State-of-the-art approaches are mostly based on supervised learning making use of large annotated datasets. Human beings, on the other hand, even…

The volume of stroke lesion is the gold standard for predicting the clinical outcome of stroke patients. However, the presence of stroke lesion may cause neural disruptions to other brain regions, and these potentially damaged regions may…

We model the elasticity of the cerebral cortex as a layered material with bending energy along the layers and elastic energy between them in both planar and polar geometries. The cortex is also subjected to axons pulling from the underlying…

Obesity is associated with higher fatality risk and altered distribution of occupant injuries in motor vehicle crashes partially because of the increased depth of abdominal soft tissue, which results in limited and delayed engagement of the…

This research proposes a new a numerical method to compute brain injury associated with concussion using the Peak Virtual Power method, using the THUMS 4.02 head model. The results indicate that mild and severe concussions could be…

The brain-skull interface (meninges) plays a critical role in governing brain motion during head impacts, yet computational models often simplify this interface using idealized contact conditions due to limited experimental data. This study…

Mild traumatic brain injury is a growing public health problem with an estimated incidence of over 1.7 million people annually in US. Diagnosis is based on clinical history and symptoms, and accurate, concrete measures of injury are…

Cardiac pulsations in the human brain have received recent interest due to their possible role in the pathogenesis of neurodegenerative diseases. Further interest stems from their possible application as an endogenous signal source that can…

The complexity of neural dynamics stems in part from the complexity of the underlying anatomy. Yet how the organization of white matter architecture constrains how the brain transitions from one cognitive state to another remains unknown.…

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…