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Mucus is a viscoelastic gel secreted by the pulmonary epithelium in the tracheobronchial region of the lungs. The coordinated beating of cilia moves mucus upwards towards pharynx, removing inhaled pathogens and particles from the airways.…

This paper proposes a hypothetical model for the dual role of respiratory aerosols and inflammatory exudates in the dynamics and progression of SARS-CoV-2 lung infection. Starting from a new paradigm in infectious disease transmission, we…

组织与器官 · 定量生物学 2025-06-02 Shi Qiru

The distribution of internal shear stresses in a 2D dislocation system is investigated when external shear stress is applied. This problem serves as a natural continuation of the previous work of Csikor and Groma (Csikor F F and Groma I…

统计力学 · 物理学 2008-12-29 Péter Dusán Ispánovity , István Groma

Trees are key roughness elements in urban environments, shaping airflow, microclimates, and pollutant dispersion. Yet the aerodynamic drag of complex tree-like structures at high Reynolds numbers remains poorly characterized compared with…

流体动力学 · 物理学 2026-03-31 T. Tokiwa , Y. Yin , R. Onishi

Lung airways are lined by a film of mucus which protects the epithelium from inhaled particles. To maintain a uniform coating, the mucus that is secreted into airways must be distributed into a film by wall-attached cilia, which constantly…

流体动力学 · 物理学 2025-11-26 Swarnaditya Hazra , Jason R. Picardo

We use numerical simulations to study the flow of a bidisperse mixture of athermal, frictionless, soft-core two dimensional spherocylinders driven in uniform steady state shear. Energy dissipation is via a viscous drag with respect to a…

软凝聚态物质 · 物理学 2019-10-07 Theodore A. Marschall , S. Teitel

An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing a bileaflet mechanical heart valve (BMHV) with a trileaflet mechanical heart valve (TMHV) in…

流体动力学 · 物理学 2018-07-05 Qianhui Li , Christoph H. Bruecker

High-resolution full lung CT scans now enable the detailed segmentation of airway trees up to the 6th branching generation. The airway binary masks display very complex tree structures that may encode biological information relevant to…

Understanding the flow dynamics of yield stress fluids in porous media presents a substantial challenge. Both experiments and extensive numerical simulations frequently show a non-linear relationship between the flow rate and the pressure…

无序系统与神经网络 · 物理学 2025-01-15 Stéphane Munier , Alberto Rosso

We develop a one-dimensional network model to predict the steady-state distribution of yield-stress fluids in branched pipe manifolds under wall-slip conditions. The model accounts for major friction losses between junctions and…

流体动力学 · 物理学 2025-11-18 Elliott Sutton , Waldo Rosales Trujillo , Adam Kowalski , Cláudio P. Fonte , Anne Juel

We incorporate local ventilation effects into a spatially dependent generalisation of the Wells--Riley model for airborne disease transmission. Aerosol production and removal through ventilation, biological deactivation, and gravitational…

定量方法 · 定量生物学 2025-07-10 Alexander Pretty , Ian M. Griffiths , Zechariah Lau , Katerina Kaouri

Collective cell migration is a highly regulated process involved in wound healing, cancer metastasis and morphogenesis. Mechanical interactions among cells provide an important regulatory mechanism to coordinate such collective motion.…

软凝聚态物质 · 物理学 2022-06-08 Xingbo Yang , Dapeng Bi , Michael Czajkowski , Matthias Merkel , M. Lisa Manning , M. Cristina Marchetti

We employ a novel computational modeling framework to perform high-fidelity direct numerical simulations of aero-structural interactions in bat-inspired membrane wings. The wing of a bat consists of an elastic membrane supported by a highly…

流体动力学 · 物理学 2025-04-09 Sushrut Kumar , Jung-Hee Seo , Rajat Mittal

The flow simulation in alveolar region is imperative in understanding transport of particles and designing aerosol drug delivery systems. Air flow is dependent on alveolar geometry and ventilation conditions. In this work a three…

流体动力学 · 物理学 2018-06-04 M. Monjezi , A. Rouhollahi , M. S. Saidi , B. M. Afshary

During embryonic morphogenesis, tissues undergo dramatic deformations in order to form functional organs. Similarly, in adult animals, living cells and tissues are continually subjected to forces and deformations. Therefore, the success of…

软凝聚态物质 · 物理学 2024-05-06 Michael J. Hertaeg , Suzanne M. Fielding , Dapeng Bi

The origin of the abrupt shear thickening observed in some dense suspensions has been recently argued to be a transition from frictionless (lubricated) to frictional interactions between immersed particles. The Wyart-Cates rheological…

软凝聚态物质 · 物理学 2021-07-08 Romain Mari , Ryohei Seto

The dispersion of plant pathogens, such as rust spores, is responsible for more than 20% of global yield loss annually, and poses a significant threat to human health. However, the release mechanics of pathogens from flexible plant surfaces…

流体动力学 · 物理学 2023-07-26 Zixuan Wu , Saikat Basu , Seungho Kim , Mark Sorrells , Francisco J. Beron-Vera , Sunghwan Jung

This article aims to make a detailed analysis of co-flowing plane Couette flows. Particularly, the variation of flow quantities from the turbulent to non-turbulent region is studied. While the enstrophy exhibits a sharp jump, the other…

流体动力学 · 物理学 2022-11-01 Manohar Teja Kalluri , Vagesh D. Narasimhamurthy

Sleep Apnea Syndrome (SAS) is defined as a partial or total closure of the patient upper airways during sleep. The term "collapsus" (or collapse) is used to describe this closure. From a fluid mechanical point of view, this collapse can be…

医学物理 · 物理学 2007-05-23 Yohan Payan , Xavier Pelorson , Pascal Perrier

A plethora of natural and industrial shear-driven granular flows exhibit particle-size segregation. Its occurrence is commonly attributed to two primary mechanisms: kinetic sieving and squeeze expulsion. While kinetic sieving is relatively…

软凝聚态物质 · 物理学 2026-04-08 Alexander J. Navarrete , Leonardo Gordillo , Tomás Trewhela