相关论文: Representation Learning for Integrating Multi-doma…

Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images…

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

We propose an approach to self-supervised representation learning based on maximizing mutual information between features extracted from multiple views of a shared context. For example, one could produce multiple views of a local…

Observational studies are regarded as economic alternatives to randomized trials, often used in their stead to investigate and determine treatment efficacy. Due to lack of sample size, observational studies commonly combine data from…

Reinforcement Learning (RL) has recently been applied to sequential estimation and prediction problems identifying and developing hypothetical treatment strategies for septic patients, with a particular focus on offline learning with…

Drug repositioning is an attractive cost-efficient strategy for the development of treatments for human diseases. Here, we propose an interpretable model that learns disease self-representations for drug repositioning. Our…

We consider a randomized controlled trial between two groups. The objective is to identify a population with characteristics such that the test therapy is more effective than the control therapy. Such a population is called a subgroup. This…

For the early identification, diagnosis, and treatment of mental health illnesses, the integration of deep learning (DL) and machine learning (ML) has started playing a significant role. By evaluating complex data from imaging, genetics,…

There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information…

In many applications, data can be heterogeneous in the sense of spanning latent groups with different underlying distributions. When predictive models are applied to such data the heterogeneity can affect both predictive performance and…

Mental disorder populations exhibit pronounced heterogeneity -- that is, the significant differences between samples -- poses a significant challenge to the definition of positive pairs in contrastive learning. To address this, we propose a…

Recent studies in neuroscience highlight the significant potential of brain connectivity networks, which are commonly constructed from functional magnetic resonance imaging (fMRI) data for brain disorder diagnosis. Traditional brain…

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Detecting dynamic patterns of task-specific responses shared across heterogeneous datasets is an essential and challenging problem in many scientific applications in medical science and neuroscience. In our motivating example of rodent…

Textual data from social platforms captures various aspects of mental health through discussions around and across issues, while users reach out for help and others sympathize and offer support. We propose a comprehensive framework that…

Improving performance in multiple domains is a challenging task, and often requires significant amounts of data to train and test models. Active learning techniques provide a promising solution by enabling models to select the most…

Complex multilayer network datasets have become ubiquitous in various applications, including neuroscience, social sciences, economics, and genetics. Notable examples include brain connectivity networks collected across multiple patients or…

With the rapid development of high-throughput technologies, parallel acquisition of large-scale drug-informatics data provides huge opportunities to improve pharmaceutical research and development. One significant application is the purpose…

Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction.…