相关论文: Feasibility Assessment of an Optically Powered Dig…
The design and benchtop operation of a wireless miniature epiretinal stimulator implant is reported. The implant is optically powered and controlled using safe illumination at near-infrared wavelengths. An application-specific integrated…
Implantable retinal prostheses offer a promising solution to restore partial vision by circumventing damaged photoreceptor cells in the retina and directly stimulating the remaining functional retinal cells. However, the information…
The majority of inherited retinal degenerations are due to photoreceptor cell death. In many cases ganglion cells are spared making it possible to stimulate them to restore visual function. Several studies (Bi et al., 2006; Lin et al.,…
Imaging neuronal activity non-invasively in vivo is of tremendous interest, but current imaging techniques lack either functional contrast or necessary microscopic resolution. The retina is the only part of the central nervous system (CNS)…
Three critical improvements for present day and future retinal vision implants are proposed and discussed: (1) A time profile for the stimulation current that leads predominantly to transverse stimulation of nerve cells; (2) auxiliary…
In recent years, numerous research efforts have been dedicated towards developing efficient implantable devices for brain stimulation. However, there are limitations and challenges with the current technologies. Firstly, the stimulation of…
In the present contribution, we introduce a wireless optical communication-based system architecture which is shown to significantly improve the reliability and the spectral and power efficiency of the transcutaneous link in cochlear…
We present an optimized conductance-based retina microcircuit simulator which transforms light stimuli into a series of graded and spiking action potentials through photo transduction. We use discrete retinal neuron blocks based on a…
Over the brief time intervals available for processing retinal output, roughly 50 to 300 msec, the number of extra spikes generated by individual ganglion cells can be quite variable. Here, computer-generated spike trains were used to…
We consider a model of basic inner retinal connectivity where bipolar and amacrine cells interconnect, and both cell types project onto ganglion cells, modulating their response output to the brain visual areas. We derive an analytical…
Implementing accurate models of the retina is a challenging task, particularly in the context of creating visual prosthetics and devices. Notwithstanding the presence of diverse artificial renditions of the retina, the imperative task…
Targeted light delivery into biological tissue is needed in applications such as optogenetic stimulation of the brain and in vivo functional or structural imaging of tissue. These applications require very compact, soft, and flexible…
Two computational models to be used as tools for experimental research on the retinal implant are presented. In the first model, the electric field produced by a multi-electrode array in a uniform retina is calculated. In the second model,…
Retinal implants aim to restore functional vision despite photoreceptor degeneration, yet are fundamentally constrained by low resolution electrode arrays and patient-specific perceptual distortions. Most deployed encoders rely on…
In the present work, we introduce a novel cochlear implant (CI) architecture, namely all-optical CI (AOCI), which directly converts acoustic to optical signals capable of stimulating the cochlear neurons. First, we describe the…
The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge…
Neuromorphic image sensors draw inspiration from the biological retina to implement visual computations in electronic hardware. Gain control in phototransduction and temporal differentiation at the first retinal synapse inspired the first…
Inspired by the data-efficient spiking mechanism of neurons in the human eye, event cameras were created to achieve high temporal resolution with minimal power and bandwidth requirements by emitting asynchronous, per-pixel intensity changes…
Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on…
Optogenetics has emerged as a powerful tool for disease modeling, enabling precise control of cellular activities through light stimulation and providing a valuable insights into disease mechanisms and therapeutic possibilities. Innovative…