相关论文: Spiral- and scroll-wave dynamics in mathematical m…

Ventricular tachycardia (VT) and ventricular fibrillation (VF) are lethal rhythm disorders, which are associated with the occurrence of abnormal electrical scroll waves in the heart. Given the technical limitations of imaging and probing,…

Nonlinear waves of the reaction-diffusion (RD) type occur in many biophysical systems, including the heart, where they initiate cardiac contraction. Such waves can form vortices called scroll waves, which result in the onset of…

We compare and contrast spiral- and scroll-wave dynamics in five different mathematical models for cardiac tissue. The first is the TP06 model, due to ten Tusscher and Panfilov, which is based on the Hodgkin-Huxley formalism; the remaining…

We present systematic numerical studies of electrical-wave propagation in two-dimensional (2D) and three-dimensional (3D) mathematical models, for human, ventricular tissue with myocyte cells that are attached (a) regularly and (b) randomly…

Spatial variations in the electrical properties of cardiac tissue can occur because of cardiac diseases. We introduce such gradients into mathematical models for cardiac tissue and then study, by extensive numerical simulations, their…

Every sixth death in industrialised countries occurs because of cardiac arrhythmias like ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of…

The gyro-resonant cosmic-ray (CR) streaming instability is believed to play a crucial role in CR transport, leading to growth of Alfv\'en waves at small scales that scatter CRs, and impacts the interaction of CRs with the ISM on large…

We present results from the first global 3D MHD simulations of accretion disks in Cataclysmic Variable (CV) systems in order to investigate the relative importance of angular momentum transport via turbulence driven by the magnetorotational…

Spiral waves of excitation in cardiac tissue are associated with life-threatening cardiac arrhythmias. It is, therefore, important to study the electrophysiological factors that affect the dynamics of these spiral waves. By using an…

Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been linked to the onset and progression of cardiovascular…

Intracellular calcium is regulated in part by the release of Ca$^{2+}$ ions from the endoplasmic reticulum via inositol-4,5-triphosphate receptor (IP$_3$R) channels (among other possibilities such as RyR and L-type calcium channels). The…

Disorganized electrical activity in the heart leads to sudden cardiac death. To what extent can this electrical turbulence be viewed as classical fluid turbulence,which is an important central problem in modern physics? We investigate,for…

Unbroken and broken spiral waves, in partial-differential-equation (PDE) models for cardiac tissue, are the mathematical analogs of life-threatening cardiac arrhythmias, namely, ventricular tachycardia (VT) and ventricular-fibrillation…

Cosmic rays (CRs) have critical impacts in the multiphase interstellar medium (ISM), driving dynamical motions in low-density plasma and modifying the ionization state, temperature, and chemical composition of higher-density atomic and…

We perform global three-dimensional MHD simulations of unstratified accretion disks in cataclysmic variables (CVs). By including mass inflow via an accretion stream, we are able to evolve the disk to a steady state. We investigate the…

We applied a periodic magnetic field of frequency 16 Hz and amplitude 16 nT to a human I_Ks channel, expressed in a Xenopus oocyte and varied the membrane depolarization between -100 mV and +100 mV. We observed a maximal increase of about…

We study how well the complex gas velocity fields induced by massive spiral arms are modelled by the hydrodynamical simulations we used to constrain the dark matter fraction in nearby spiral galaxies (Kranz et al. 2001, 2003). More…

Fibroblast-myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD)…

We investigate the dynamics of spatially discordant alternans (SDA) driven by an instability of intracellular calcium cycling using both amplitude equations [P. S. Skardal, A. Karma, and J. G. Restrepo, Phys. Rev. Lett. 108, 108103 (2012)]…

In embryogenesis, epithelial cells, acting as individual entities or as coordinated aggregates in a tissue, exhibit strong coupling between chemical signalling and mechanical responses to internally or externally applied stresses.…