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Background: Mutations in KMT2B are a recognized cause of early-onset complex dystonia, with deep brain stimulation (DBS) of the internal globus pallidus (GPi-DBS) being an effective treatment. However, gait impairment, particularly freezing…

神经元与认知 · 定量生物学 2025-02-20 Laura Cif , Diane Demailly , Xavier Vasques , Delphine de Verbizier , Philippe Coubes , Kathleen Gorman , Manju A Kurian

Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…

Parkinson's Disease (PD) is a slowly evolving neuro-logical disease that affects about 1% of the population above 60 years old, causing symptoms that are subtle at first, but whose intensity increases as the disease progresses. Automated…

Gait analysis is crucial for the diagnosis and monitoring of movement disorders like Parkinson's Disease. While computer vision models have shown potential for objectively evaluating parkinsonian gait, their effectiveness is limited by…

计算机视觉与模式识别 · 计算机科学 2025-11-13 Vida Adeli , Soroush Mehraban , Majid Mirmehdi , Alan Whone , Benjamin Filtjens , Amirhossein Dadashzadeh , Alfonso Fasano , Andrea Iaboni , Babak Taati

Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution…

机器学习 · 计算机科学 2020-10-16 Weijian Li , Wei Zhu , E. Ray Dorsey , Jiebo Luo

Hypomimia is a condition in the early stages of the progression of Parkinsons disease that limits the movement of facial muscles, restricting the accurate depiction of facial expressions. Also known as facial masking, this condition is an…

医学物理 · 物理学 2021-11-25 Simoni Mishra

Parkinson's disease (PD) is a neurodegenerative condition characterized by frequently changing motor symptoms, necessitating continuous symptom monitoring for more targeted treatment. Classical time series classification and deep learning…

机器学习 · 计算机科学 2025-06-03 Cedric Donié , Neha Das , Satoshi Endo , Sandra Hirche

Fundamental knowledge in activity recognition of individuals with motor disorders such as Parkinson's disease (PD) has been primarily limited to detection of steady-state/static tasks (sitting, standing, walking). To date, identification of…

信号处理 · 电气工程与系统科学 2021-10-13 Mahdieh Kazemimoghadam , Nicholas P. Fey

Parkinsons disease, PD, is a chronic condition that affects motor skills and includes symptoms like tremors and rigidity. The current diagnostic procedure uses patient assessments to evaluate symptoms and sometimes a magnetic resonance…

图像与视频处理 · 电气工程与系统科学 2022-01-14 Sabrina Zhu

Wearable technology for the automatic detection of gait events has recently gained growing interest, enabling advanced analyses that were previously limited to specialist centres and equipment (e.g., instrumented walkway). In this study, we…

信号处理 · 电气工程与系统科学 2020-09-01 Matteo Gadaleta , Giulia Cisotto , Michele Rossi , Rana Zia Ur Rehman , Lynn Rochester , Silvia Del Din

Parkinson's disease ranks as the second most prevalent neurodegenerative disorder globally. This research aims to develop a system leveraging Mixed Reality capabilities for tracking and assessing eye movements. In this paper, we present a…

Gait encodes rich biometric and behavioural information, yet leveraging the manner of walking to infer psychological traits remains a challenging and underexplored problem. We introduce a hierarchical Multi-Stage Mixture of Movement Experts…

计算机视觉与模式识别 · 计算机科学 2025-10-08 Andy Cǎtrunǎ , Adrian Cosma , Emilian Rǎdoi

Resting-state EEG (rs-EEG) has been demonstrated to aid in Parkinson's disease (PD) diagnosis. In particular, the power spectral density (PSD) of low-frequency bands ({\delta} and {\theta}) and high-frequency bands ({\alpha} and \b{eta})…

Frailty is a condition in aging medicine characterized by diminished physiological reserve and increased vulnerability to stressors. However, frailty assessment remains subjective, heterogeneous, and difficult to scale in clinical practice.…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Laura McDaniel , Basudha Pal , Crystal Szczesny , Yuxiang Guo , Zhaoyang Wang , Ryan Roemmich , Peter Abadir , Rama Chellappa

Video-based gait analysis has become a promising approach for assessing motor impairment in children with cerebral palsy (CP). However, existing methods usually rely on either pose sequences or handcrafted gait features alone, making it…

图像与视频处理 · 电气工程与系统科学 2026-03-25 Kaiyuan Yang , Xupeng Chen , Jiangpeng He

Scoliosis is a spinal curvature disorder that is difficult to detect early and can compress the chest cavity, impacting respiratory function and cardiac health. Especially for adolescents, delayed detection and treatment result in worsening…

计算机视觉与模式识别 · 计算机科学 2025-04-08 Haiqing Li , Yuzhi Guo , Feng Jiang , Qifeng Zhou , Hehuan Ma , Junzhou Huang

Parkinson's disease is a neurological condition that occurs in nearly 1% of the world's population. The disease is manifested by a drop in dopamine production, symptoms are cognitive and behavioural and include a wide range of personality…

图像与视频处理 · 电气工程与系统科学 2024-01-08 Maria Frasca , Davide La Torre , Gabriella Pravettoni , Ilaria Cutica

In this work we develop a new method of diagnosing the nervous system diseases and a new approach in studying human gait dynamics with the help of the theory of discrete non-Markov random processes. The stratification of the phase clouds…

医学物理 · 物理学 2009-11-10 Renat Yulmetyev , Sergey Demin , Natalya Emelyanova , Fail Gafarov , Peter Hanggi

Gait is increasingly recognized as a vital sign, yet current approaches treat it as a symptom of specific pathologies rather than a systemic biomarker. We developed a gait foundation model for 3D skeletal motion from 3,414 deeply phenotyped…

Forensic gait analysis can aid the investigation of crimes through comparing features of gait captured in video footage. Modelling the probative value of gait evidence requires an understanding of the variation of features of gait between…

应用统计 · 统计学 2026-05-06 Ruoyun Hui , Amy L Wilson , Colin Aitken , Ivan Birch , Nadia Asgeirsdottir , Graham Jackson