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Hypoxic-Ischemic Encephalopathy (HIE) affects 1 to 5 out of every 1,000 newborns, with 30% to 50% of cases resulting in adverse neurocognitive outcomes. However, these outcomes can only be reliably assessed as early as age 2. Therefore,…

图像与视频处理 · 电气工程与系统科学 2024-11-11 Rina Bao , Sheng He , Ellen Grant , Yangming Ou

Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family…

机器学习 · 计算机科学 2020-06-01 Ali Mert Ertugrul , Yu-Ru Lin , Tugba Taskaya-Temizel

Studies often estimate associations between an outcome and multiple variates. For example, studies of diagnostic test accuracy estimate sensitivity and specificity, and studies of predictive and prognostic factors typically estimate…

Rich meta-epidemiological data sets have been collected to explore associations between intervention effect estimates and study-level characteristics. Welton et al. proposed models for the analysis of meta-epidemiological data, but these…

应用统计 · 统计学 2017-11-28 Kirsty Rhodes , David Mawdsley , Rebecca Turner , Hayley Jones , Jelena Savovic , Julian Higgins

We develop a nonparametric Bayesian modeling framework for clustered ordinal responses in developmental toxicity studies, which typically exhibit extensive heterogeneity. The primary focus of these studies is to examine the dose-response…

统计方法学 · 统计学 2024-08-22 Jizhou Kang , Athanasios Kottas

Propensity scores are commonly used to reduce the confounding bias in non-randomized observational studies for estimating the average treatment effect. An important assumption underlying this approach is that all confounders that are…

统计方法学 · 统计学 2022-08-02 Youfei Yu , Jiacong Du , Min Zhang , Zhenke Wu , Andrew M. Ryan , Bhramar Mukherjee

In meta-learning an agent extracts knowledge from observed tasks, aiming to facilitate learning of novel future tasks. Under the assumption that future tasks are 'related' to previous tasks, the accumulated knowledge should be learned in a…

机器学习 · 统计学 2019-05-21 Ron Amit , Ron Meir

While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best approach under non-proportional hazards. A wide range of parametric and non-parametric…

Maternal exposure to environmental chemicals during pregnancy can alter birth and children's health outcomes. Research seeks to identify critical windows, time periods when the exposures can change future health outcomes, and estimate the…

统计方法学 · 统计学 2022-04-14 Daniel Mork , Ander Wilson

We investigate the task of estimating the conditional average causal effect of treatment-dosage pairs from a combination of observational data and assumptions on the causal relationships in the underlying system. This has been a…

机器学习 · 计算机科学 2022-05-31 Alexis Bellot , Anish Dhir , Giulia Prando

We present new results on average causal effects in settings with unmeasured exposure-outcome confounding. Our results are motivated by a class of estimands, e.g., frequently of interest in medicine and public health, that are currently not…

统计方法学 · 统计学 2023-12-25 Lan Wen , Aaron L. Sarvet , Mats J. Stensrud

Meta-analyses in orphan diseases and small populations generally face particular problems including small numbers of studies, small study sizes, and heterogeneity of results. However, the heterogeneity is difficult to estimate if only very…

统计方法学 · 统计学 2018-09-11 Tim Friede , Christian Röver , Simon Wandel , Beat Neuenschwander

Prescription opioids relieve moderate-to-severe pain after surgery, but overprescription can lead to misuse and overdose. Understanding factors associated with post-surgical opioid refills is crucial for improving pain management and…

统计方法学 · 统计学 2025-09-16 Eileen Yang , Donglin Zeng , Mark Bicket , Yi Li

Depression and post-traumatic stress disorder (PTSD) are psychiatric conditions commonly associated with experiencing a traumatic event. Estimating mental health status through non-invasive techniques such as activity-based algorithms can…

Inferring causal effects of continuous-valued treatments from observational data is a crucial task promising to better inform policy- and decision-makers. A critical assumption needed to identify these effects is that all confounding…

Background: Adverse Childhood Experiences (ACEs), a set of negative events and processes that a person might encounter during childhood and adolescence, have been proven to be linked to increased risks of a multitude of negative health…

计算机与社会 · 计算机科学 2019-12-12 Jon Hael Brenas , Eun Kyong Shin , Arash Shaban-Nejad

In this paper, we show that organisms can be modeled as hierarchical Bayesian control systems with small world and information bottleneck (bow-tie) network structure. Such systems combine hierarchical perception with hierarchical goal…

神经元与认知 · 定量生物学 2021-02-03 Rutger Goekoop , Roy de Kleijn

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

定量方法 · 定量生物学 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

Masked autoencoder (MAE), a simple and effective self-supervised learning framework based on the reconstruction of masked image regions, has recently achieved prominent success in a variety of vision tasks. Despite the emergence of…

机器学习 · 计算机科学 2023-06-09 Lingjing Kong , Martin Q. Ma , Guangyi Chen , Eric P. Xing , Yuejie Chi , Louis-Philippe Morency , Kun Zhang

When considering the effect a treatment will cause in a population of interest, we often look to evidence from randomized controlled trials. In settings where multiple trials on a treatment are available, we may wish to synthesize the…

统计方法学 · 统计学 2023-09-08 Nicole Schnitzler , Eloise Kaizar
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