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In the realm of cerebrovascular monitoring, primary metrics typically include blood pressure, which influences cerebral blood flow (CBF) and is contingent upon vessel radius. Measuring CBF non-invasively poses a persistent challenge,…

It has been shown that light speckle fluctuations provide a means for noninvasive measurements of cerebral blood flow index (CBFi). While conventional Diffuse Correlation Spectroscopy (DCS) provides marginal brain sensitivity for CBFi in…

Diffusing wave spectroscopy (DWS) is a group of techniques used to measure the dynamics of a scattering medium in a non-invasive manner. DWS methods rely on detecting the speckle light field from the moving scattering media and measuring…

图像与视频处理 · 电气工程与系统科学 2023-07-03 Yu Xi Huang , Simon Mahler , Jerome Mertz , Changhuei Yang

Significance: Measuring cerebral blood flow (CBF) is crucial for diagnosing various cerebral diseases. An affordable, wearable, and fiber-free continuous-wave speckle contrast flowmetry (CW-DSCF) technique has been developed for continuous…

定量方法 · 定量生物学 2025-02-13 Chaebeom Yeo , Xuhui Liu , Mehrana Mohtasebi , Faezeh Akbari , Faraneh Fathi , Guoqiang Yu

Diffuse correlation spectroscopy (DCS) analyzes the autocorrelation function of photons scattered by red blood cells, enabling non-invasive, continuous measurement of deep tissue blood flow at the bedside. Multi-layer DCS models (two- and…

Speckle contrast optical spectroscopy (SCOS) offers a non-invasive and cost-effective method for monitoring cerebral blood flow (CBF). However, extracting accurate CBF from SCOS necessitates precise noise pre-calibration. Errors from this…

信号处理 · 电气工程与系统科学 2025-06-23 Ninghe Liu , Yu Xi Huang , Simon Mahler , Changhuei Yang

Significance: This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain. Aim: To identify optimal source-detector distances…

医学物理 · 物理学 2023-01-05 Giles Blaney , Cristianne Fernandez , Angelo Sassaroli , Sergio Fantini

Significance: Cerebral blood flow (CBF) imaging is crucial for diagnosing cerebrovascular diseases. However, existing large neuroimaging techniques with high cost, low sampling rate, and poor mobility make them unsuitable for continuous and…

组织与器官 · 定量生物学 2024-08-26 Faezeh Akbari , Xuhui Liu , Fatemeh Hamedi , Mehrana Mohtasebi , Lei Chen , Guoqiang Yu

Diffuse correlation spectroscopy (DCS) is an emerging noninvasive technique that measures the tissue blood flow, by using near-infrared coherent point-source illumination to detect spectral changes. While machine learning has demonstrated…

机器学习 · 计算机科学 2024-02-02 Xi Chen , Xingda Li

One of the essential goals of molecular spectroscopy is to measure all fundamental molecular vibrations simultaneously. To this end, one needs to measure broadband infrared (IR) absorption and Raman scattering spectra, which provide…

Cerebral blood flow is a critical metric for cerebrovascular monitoring, with applications in stroke detection, brain injury evaluation, aging, and neurological disorders. Non-invasively measuring cerebral blood dynamics is challenging due…

Diffuse Correlation Spectroscopy (DCS) allows the label-free investigation of microvascular dynamics deep within living tissue. However, common implementations of DCS are currently limited to measurement depths of $\sim 1-1.5cm$, which can…

Purpose: The goal of this article is to introduce a technique to measure the velocity distribution of water inside each voxel of an MR image. The method is based on the use of motion sensitizing gradients with changing first moment to…

定量方法 · 定量生物学 2025-12-02 Luis Hernandez-Garcia , Alberto L. Vazquez , Doug C. Noll

We report on wide-field imaging of pulsatile microvascular blood flow in the exposed cerebral cortex of a mouse by holographic interferometry. We recorded interferograms of laser light backscattered by the tissue, beating against an…

医学物理 · 物理学 2015-10-08 L. Puyo , I. Ferezou , A. Rancillac , M. Simonutti , M. Paques , J. A. Sahel , M. Fink , M. Atlan

Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests,…

图像与视频处理 · 电气工程与系统科学 2024-07-24 Yu Xi Huang , Simon Mahler , Aidin Abedi , Julian Michael Tyszka , Yu Tung Lo , Patrick D. Lyden , Jonathan Russin , Charles Liu , Changhuei Yang

We demonstrate low-frequency interferometric impulsive stimulated Raman scattering (ISRS) imaging with high robustness to distortions by optical scattering. ISRS is a pump-probe coherent Raman spectroscopy that can capture Raman vibrational…

Intra-pixel sensitivity variations (IPSVs) in charge-coupled devices (CCDs) and complementary metal-oxide-semiconductor (CMOS) detectors constitute a significant source of astrometric error for undersampled stellar observations. Since…

天体物理仪器与方法 · 物理学 2026-03-12 Peipei Wang , Zihuang Cao , Chao Liu , Peng Wei , Xin Zhang , Jialu Nie

We propose a novel femtosecond stimulated Raman spectroscopy (FSRS) technique that combines entangled photons with interference detection to select matter pathways and enhance the resolution. Following photo excitation by an actinic pump,…

量子物理 · 物理学 2014-07-15 Konstantin E. Dorfman , Frank Schlawin , Shaul Mukamel

This paper explores the use of deep learning-based computer vision for real-time monitoring of the flow in intravenous (IV) infusions. IV infusions are among the most common therapies in hospitalized patients and, given that both…

计算机视觉与模式识别 · 计算机科学 2020-11-24 Nicola Giaquinto , Marco Scarpetta , Maurizio Spadavecchia , Gregorio Andria

X-ray photon correlation spectroscopy (XPCS) allows for the resolution of dynamic processes within a material across a wide range of length and time scales. X-ray speckle visibility spectroscopy (XSVS) is a related method that uses a single…

数值分析 · 数学 2023-01-09 Shaswat Mohanty , Christopher B. Cooper , Hui Wang , Mengning Liang , Wei Cai
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