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Whole-slide images (WSI) glomerulus segmentation is essential for accurately diagnosing kidney diseases. In this work, we propose a general and practical pipeline for glomerulus segmentation that effectively enhances both patch-level and…

图像与视频处理 · 电气工程与系统科学 2025-02-12 Quan Huu Cap

Application of machine learning techniques enables segmentation of functional tissue units in histology whole-slide images (WSIs). We built a pipeline to apply previously validated segmentation models of kidney structures and extract…

Convolutional neural networks, the state of the art for image segmentation, have been successfully applied to histology images by many computational researchers. However, the translatability of this technology to clinicians and biological…

图像与视频处理 · 电气工程与系统科学 2021-01-19 Brendon Lutnick , David Manthey , Pinaki Sarder

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

图像与视频处理 · 电气工程与系统科学 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Recognition of glomeruli lesions is the key for diagnosis and treatment planning in kidney pathology; however, the coexisting glomerular structures such as mesangial regions exacerbate the difficulties of this task. In this paper, we…

图像与视频处理 · 电气工程与系统科学 2022-03-14 Yang Nan , Fengyi Li , Peng Tang , Guyue Zhang , Caihong Zeng , Guotong Xie , Zhihong Liu , Guang Yang

Joint analysis of multiple biomarker images and tissue morphology is important for disease diagnosis, treatment planning and drug development. It requires cross-staining comparison among Whole Slide Images (WSIs) of immuno-histochemical and…

图像与视频处理 · 电气工程与系统科学 2022-07-05 Abubakr Shafique , Morteza Babaie , Mahjabin Sajadi , Adrian Batten , Soma Skdar , H. R. Tizhoosh

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

计算机视觉与模式识别 · 计算机科学 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

定量方法 · 定量生物学 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

The condition of the Glomeruli, or filter sacks, in renal Direct Immunofluorescence (DIF) specimens is a critical indicator for diagnosing kidney diseases. A digital pathology system which digitizes a glass histology slide into a Whole…

计算机视觉与模式识别 · 计算机科学 2019-09-24 Can Peng , Kun Zhao , Arnold Wiliem , Teng Zhang , Peter Hobson , Anthony Jennings , Brian C. Lovell

Automatic instance segmentation of glomeruli within kidney Whole Slide Imaging (WSI) is essential for clinical research in renal pathology. In computer vision, the end-to-end instance segmentation methods (e.g., Mask-RCNN) have shown their…

图像与视频处理 · 电气工程与系统科学 2020-07-08 Aadarsh Jha , Haichun Yang , Ruining Deng , Meghan E. Kapp , Agnes B. Fogo , Yuankai Huo

There has been a long pursuit for precise and reproducible glomerular quantification on renal pathology to leverage both research and practice. When digitizing the biopsy tissue samples using whole slide imaging (WSI), a set of serial…

计算机视觉与模式识别 · 计算机科学 2021-03-29 Ruining Deng , Haichun Yang , Aadarsh Jha , Yuzhe Lu , Peng Chu , Agnes B. Fogo , Yuankai Huo

The quantitative detection, segmentation, and characterization of glomeruli from high-resolution whole slide imaging (WSI) play essential roles in the computer-assisted diagnosis and scientific research in digital renal pathology.…

计算机视觉与模式识别 · 计算机科学 2022-06-02 Tianyuan Yao , Yuzhe Lu , Jun Long , Aadarsh Jha , Zheyu Zhu , Zuhayr Asad , Haichun Yang , Agnes B. Fogo , Yuankai Huo

A Whole Slide Image (WSI) is a high-resolution digital image created by scanning an entire glass slide containing a biological specimen, such as tissue sections or cell samples, at multiple magnifications. These images are digitally…

This study introduces a new framework for the artificial intelligence-assisted characterization of Gram-stained whole-slide images (WSIs). As a test for the diagnosis of bloodstream infections, Gram stains provide critical early data to…

图像与视频处理 · 电气工程与系统科学 2024-09-30 Jack McMahon , Naofumi Tomita , Elizabeth S. Tatishev , Adrienne A. Workman , Cristina R Costales , Niaz Banaei , Isabella W. Martin , Saeed Hassanpour

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

计算机视觉与模式识别 · 计算机科学 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Glomerulosclerosis, interstitial fibrosis, and tubular atrophy (IFTA) are histologic indicators of irrecoverable kidney injury. In standard clinical practice, the renal pathologist visually assesses, under the microscope, the percentage of…

组织与器官 · 定量生物学 2021-06-23 Brandon Ginley , Kuang-Yu Jen , Avi Rosenberg , Felicia Yen , Sanjay Jain , Agnes Fogo , Pinaki Sarder

Segmentation from renal pathological images is a key step in automatic analyzing the renal histological characteristics. However, the performance of models varies significantly in different types of stained datasets due to the appearance…

图像与视频处理 · 电气工程与系统科学 2020-02-21 Ke Mei , Chuang Zhu , Lei Jiang , Jun Liu , Yuanyuan Qiao

In digital pathology, the multiple instance learning (MIL) strategy is widely used in the weakly supervised histopathology whole slide image (WSI) classification task where giga-pixel WSIs are only labeled at the slide level. However,…

图像与视频处理 · 电气工程与系统科学 2024-03-28 Zhan Shi , Jingwei Zhang , Jun Kong , Fusheng Wang

Whole slide image (WSI) registration is an essential task for analysing the tumour microenvironment (TME) in histopathology. It involves the alignment of spatial information between WSIs of the same section or serial sections of a tissue…

图像与视频处理 · 电气工程与系统科学 2025-02-27 Behnaz Elhaminia , Abdullah Alsalemi , Esha Nasir , Mostafa Jahanifar , Ruqayya Awan , Lawrence S. Young , Nasir M. Rajpoot , Fayyaz Minhas , Shan E Ahmed Raza

The automatic registration of differently stained whole slide images (WSIs) is crucial for improving diagnosis and prognosis by fusing complementary information emerging from different visible structures. It is also useful to quickly…

图像与视频处理 · 电气工程与系统科学 2024-05-22 Marek Wodzinski , Niccolò Marini , Manfredo Atzori , Henning Müller
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