相关论文: Slide-free MUSE Microscopy to H&E Histology Modali…

The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…

In this work, we introduce MUSE (Model-based Uncertainty-aware Similarity Estimation), a training-free framework designed for model-based zero-shot 2D object detection and segmentation. MUSE leverages 2D multi-view templates rendered from…

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue…

Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining, serves as the benchmark for disease diagnosis and comprehensive clinical assessment of tissue. However, the process is laborious and time-consuming,…

The classification of histopathological images is of great value in both cancer diagnosis and pathological studies. However, multiple reasons, such as variations caused by magnification factors and class imbalance, make it a challenging…

We present the marginal unbiased score expansion (MUSE) method, an algorithm for generic high-dimensional hierarchical Bayesian inference. MUSE performs approximate marginalization over arbitrary non-Gaussian latent parameter spaces,…

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

We present aMUSEd, an open-source, lightweight masked image model (MIM) for text-to-image generation based on MUSE. With 10 percent of MUSE's parameters, aMUSEd is focused on fast image generation. We believe MIM is under-explored compared…

In computational pathology, few-shot whole slide image classification is primarily driven by the extreme scarcity of expert-labeled slides. Recent vision-language methods incorporate textual semantics generated by large language models, but…

We present a novel information-theoretic approach to introduce dependency among features of a deep convolutional neural network (CNN). The core idea of our proposed method, called MUSE, is to combine MUtual information and SElf-information…

Double staining in histopathology, particularly for metaplastic breast cancer, typically employs H&E and P63 dyes. However, P63's tissue damage and high cost necessitate alternative methods. This study introduces xAI-CycleGAN, an advanced…

Unified visual tokenization faces a fundamental trade-off between high-fidelity pixel reconstruction (spatial equivariance) and semantic abstraction (conceptual invariance). We attribute this conflict to Manifold Misalignment: naive joint…

Self-supervised learning (SSL) enables learning useful inductive biases through utilizing pretext tasks that require no labels. The unlabeled nature of SSL makes it especially important for whole slide histopathological images (WSIs), where…

Histopathology image analysis is fundamental to digital pathology, with hematoxylin and eosin (H&E) staining as the gold standard for diagnostic and prognostic assessments. While H&E imaging effectively highlights cellular and tissue…

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and…

We propose a novel hematoxylin and eosin (H&E) stain normalization method based on a modified U-Net neural network architecture. Unlike previous deep-learning methods that were often based on generative adversarial networks (GANs), we take…

Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular species in biological tissue with…

Confocal laser endomicroscopy (CLE) allow on-the-fly in vivo intraoperative imaging in a discreet field of view, especially for brain tumors, rather than extracting tissue for examination ex vivo with conventional light microscopy.…

Large amounts of digitized histopathological data display a promising future for developing pathological foundation models via self-supervised learning methods. Foundation models pretrained with these methods serve as a good basis for…