相关论文: Handling confounding variables in statistical shap…

Cardiac deformation is a crucial biomarker for the evaluation of cardiac function. Current methods for estimating cardiac strain might underestimate local deformation due to through-plane motion and segmental averaging. Mesh-based mapping…

Confounder selection, namely choosing a set of covariates to control for confounding between a treatment and an outcome, is arguably the most important step in the design of an observational study. Previous methods, such as Pearl's…

Representing 3D shape deformations by linear models in high-dimensional space has many applications in computer vision and medical imaging, such as shape-based interpolation or segmentation. Commonly, using Principal Components Analysis a…

Recent developments in computer vision have enabled the availability of segmented images across various domains, such as medicine, where segmented radiography images play an important role in diagnosis-making. As prediction problems are…

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

Statistical shape modeling aims at capturing shape variations of an anatomical structure that occur within a given population. Shape models are employed in many tasks, such as shape reconstruction and image segmentation, but also shape…

Learning spatial-temporal correspondences in cardiac motion from images is important for understanding the underlying dynamics of cardiac anatomical structures. Many methods explicitly impose smoothness constraints such as the…

Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. Many approaches have been developed to better estimate the cardiac muscle deformation, and to obtain a practical model to be used in diagnostic…

We present an unsupervised data-driven approach for non-rigid shape matching. Shape matching identifies correspondences between two shapes and is a fundamental step in many computer vision and graphics applications. Our approach is designed…

We describe and analyze algorithms for shape-constrained symbolic regression, which allows the inclusion of prior knowledge about the shape of the regression function. This is relevant in many areas of engineering -- in particular whenever…

Quantification of anatomical shape changes currently relies on scalar global indexes which are largely insensitive to regional or asymmetric modifications. Accurate assessment of pathology-driven anatomical remodeling is a crucial step for…

Cardiac parametric mapping is useful for evaluating cardiac fibrosis and edema. Parametric mapping relies on single-shot heartbeat-by-heartbeat imaging, which is susceptible to intra-shot motion during the imaging window. However, reducing…

Marginal structural models are a popular tool for investigating the effects of time-varying treatments, but they require an assumption of no unobserved confounders between the treatment and outcome. With observational data, this assumption…

Missingness and measurement frequency are two sides of the same coin. How frequent should we measure clinical variables and conduct laboratory tests? It depends on many factors such as the stability of patient conditions, diagnostic…

Spatial confounding is a fundamental issue in spatial regression models which arises because spatial random effects, included to approximate unmeasured spatial variation, are typically not independent of covariates in the model. This can…

In cases of pressure or volume overload, probing cardiac function may be difficult because of the interactions between shape and deformations.In this work, we use the LDDMM framework and parallel transport to estimate and reorient…

The lack of non-parametric statistical tests for confounding bias significantly hampers the development of robust, valid and generalizable predictive models in many fields of research. Here I propose the partial and full confounder tests,…

This study addresses the challenges of confounding effects and interpretability in artificial-intelligence-based medical image analysis. Whereas existing literature often resolves confounding by removing confounder-related information from…

The reliability of machine learning systems critically assumes that the associations between features and labels remain similar between training and test distributions. However, unmeasured variables, such as confounders, break this…

The desire to train complex machine learning algorithms and to increase the statistical power in association studies drives neuroimaging research to use ever-larger datasets. The most obvious way to increase sample size is by pooling scans…