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The standard paradigm for confirmatory clinical trials is to compare experimental treatments with a control, for example the standard of care or a placebo. However, it is not always the case that a suitable control exists. Efficient…

统计方法学 · 统计学 2024-10-29 Thomas Burnett , Thomas Jaki

Simultaneous tests of superiority and non-inferiority hypotheses on multiple endpoints are often performed in clinical trials to demonstrate that a new treatment is superior over a control on at least one endpoint and non-inferior on the…

统计方法学 · 统计学 2023-10-02 Wenfeng Chen , Naiqing Zhao , Guoyou Qin , Jie Chen

Understanding the continuous evolution of populations from discrete temporal snapshots is a critical research challenge, particularly in fields like developmental biology and systems medicine where longitudinal tracking of individual…

机器学习 · 统计学 2025-10-21 Byoungwoo Park , Juho Lee

In recent years, researchers pay growing attention to the few-shot learning (FSL) task to address the data-scarce problem. A standard FSL framework is composed of two components: i) Pre-train. Employ the base data to generate a CNN-based…

计算机视觉与模式识别 · 计算机科学 2021-12-06 Shuai Shao , Lei Xing , Rui Xu , Weifeng Liu , Yan-Jiang Wang , Bao-Di Liu

We propose nonparametric open-end sequential testing procedures that can detect all types of changes in the contemporary distribution function of possibly multivariate observations. Their asymptotic properties are theoretically investigated…

统计方法学 · 统计学 2022-11-15 Mark Holmes , Ivan Kojadinovic , Alex Verhoijsen

We propose a general method for distributed Bayesian model choice, using the marginal likelihood, where a data set is split in non-overlapping subsets. These subsets are only accessed locally by individual workers and no data is shared…

统计计算 · 统计学 2022-10-18 Alexander Buchholz , Daniel Ahfock , Sylvia Richardson

Joint models of longitudinal and event-time data have been extensively studied and applied in many different fields. Estimation of joint models is challenging, most present procedures are computational expensive and have a strict…

统计方法学 · 统计学 2018-09-05 Yanqiao Zheng , Xiaobing Zhao , Xiaoqi Zhang

Complex statistical machine learning models are increasingly being used or considered for use in high-stakes decision-making pipelines in domains such as financial services, health care, criminal justice and human services. These models are…

应用统计 · 统计学 2017-07-04 Alexandra Chouldechova , Max G'Sell

In this paper, we study different discrete data clustering methods, which use the Model-Based Clustering (MBC) framework with the Multinomial distribution. Our study comprises several relevant issues, such as initialization, model…

机器学习 · 计算机科学 2015-09-08 Md. Abul Hasnat , Julien Velcin , Stéphane Bonnevay , Julien Jacques

This study evaluates the ability of Large Language Model (LLM)-based Subpopulation Representative Models (SRMs) to generalize from empirical data, utilizing in-context learning with data from the 2016 and 2020 American National Election…

机器学习 · 计算机科学 2024-02-13 Gabriel Simmons , Vladislav Savinov

Many data sets contain an inherent multilevel structure, for example, because of repeated measurements of the same observational units. Taking this structure into account is critical for the accuracy and calibration of any statistical…

统计方法学 · 统计学 2020-05-07 Topi Paananen , Alejandro Catalina , Paul-Christian Bürkner , Aki Vehtari

Multilevel regression and poststratification (MRP) is a popular method for addressing selection bias in subgroup estimation, with broad applications across fields from social sciences to public health. In this paper, we examine the…

统计方法学 · 统计学 2023-03-06 Yajuan Si

Ensemble learning combines several individual models to obtain a better generalization performance. In this work we present a practical method for estimating the joint power of several classifiers. It differs from existing approaches which…

人工智能 · 计算机科学 2023-12-22 Simi Haber , Yonatan Wexler

We introduce Midpoint Generative Models (MGM), a principled framework for training one-step generative models. MGM is based on a simple symmetry of Flow Matching with linear interpolation: when the two endpoint distributions coincide, the…

机器学习 · 计算机科学 2026-05-29 Daniil Shlenskii , Nikita Gushchin , Lev Novitskiy , Dmitry V. Dylov , Alexander Korotin

Multilevel models (mixed-effect models or hierarchical linear models) are now a standard approach to analysing clustered and longitudinal data in the social, behavioural and medical sciences. This review article focuses on multilevel linear…

统计方法学 · 统计学 2019-07-16 George Leckie

For solving constrained multicriteria problems, we introduce the multiobjective barrier method (MBM), which extends the scalar-valued internal penalty method. This multiobjective version of the classical method also requires a penalty…

最优化与控制 · 数学 2018-04-02 Ellen H. Fukuda , L. M. Grana Drummond , Fernanda M. P. Raupp

In randomized trials, repeated measures of the outcome are routinely collected. The mixed model for repeated measures (MMRM) leverages the information from these repeated outcome measures, and is often used for the primary analysis to…

统计方法学 · 统计学 2023-07-20 Bingkai Wang , Yu Du

We consider estimation and inference in a linear model with endogenous regressors where the parameters of interest change across two samples. If the first-stage is common, we show how to use this information to obtain more efficient…

计量经济学 · 经济学 2024-06-26 Bertille Antoine , Otilia Boldea , Niccolo Zaccaria

Mixed-effect models are flexible tools for researchers in a myriad of fields, but that flexibility comes at the cost of complexity and if users are not careful in how their model is specified, they could be making faulty inferences from…

统计方法学 · 统计学 2023-08-28 Keith R. Lohse , Allan J. Kozlowski , Michael J. Strube

In many applications, different populations are compared using data that are sampled in a biased manner. Under sampling biases, standard methods that estimate the difference between the population means yield unreliable inferences. Here we…

统计理论 · 数学 2019-11-12 Dave Zachariah , Petre Stoica