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Several biomarkers are hypothesized to indicate early stages of Alzheimer's disease, well before the cognitive symptoms manifest. Their precise relations to the disease progression, however, is poorly understood. This lack of understanding…

应用统计 · 统计学 2025-05-12 Mingyuan Li , Zheyu Wang , Akihiko Nishimura

To improve the statistical power for imaging biomarker detection, we propose a latent variable-based statistical network analysis (LatentSNA) that combines brain functional connectivity with internalizing psychopathology, implementing…

统计方法学 · 统计学 2023-09-21 Selena Wang , Yunhe Liu , Wanwan Xu , Xinyuan Tian , Yize Zhao

Statistical shape analysis is a powerful tool to assess organ morphologies and find shape changes associated to a particular disease. However, imbalance in confounding factors, such as demographics might invalidate the analysis if not taken…

Cerebrovascular pathology significantly contributes to cognitive decline and neurological disorders, underscoring the need for advanced tools to assess vascular integrity. Three-dimensional Time-of-Flight Magnetic Resonance Angiography (3D…

图像与视频处理 · 电气工程与系统科学 2025-07-11 Abrar Faiyaz , Nhat Hoang , Giovanni Schifitto , Md Nasir Uddin

Objective: ascending aortic aneurysm growth prediction is still challenging in clinics. In this study, we evaluate and compare the ability of local and global shape features to predict ascending aortic aneurysm growth. Material and methods:…

Modern neuroimaging technologies, combined with state-of-the-art data processing pipelines, have made it possible to collect longitudinal observations of an individual's brain connectome at different ages. It is of substantial scientific…

应用统计 · 统计学 2019-08-16 Lu Wang , Zhengwu Zhang

Estimating time-varying graphical models are of paramount importance in various social, financial, biological, and engineering systems, since the evolution of such networks can be utilized for example to spot trends, detect anomalies,…

机器学习 · 统计学 2023-02-07 Hang Yu , Songwei Wu , Justin Dauwels

Advances in experimental neuroscience have transformed our ability to explore the structure and function of neural circuits. At the same time, advances in machine learning have unleashed the remarkable computational power of artificial…

神经元与认知 · 定量生物学 2021-11-23 SueYeon Chung , L. F. Abbott

In recent years, convolutional neural networks for semantic segmentation of breast ultrasound (BUS) images have shown great success; however, two major challenges still exist. 1) Most current approaches inherently lack the ability to…

图像与视频处理 · 电气工程与系统科学 2024-03-26 Kyle Lucke , Aleksandar Vakanski , Min Xian

Exponential random graph models (ERGMs), also known as p* models, have been utilized extensively in the social science literature to study complex networks and how their global structure depends on underlying structural components. However,…

应用统计 · 统计学 2015-05-19 Sean L. Simpson , Satoru Hayasaka , Paul J. Laurienti

The characterisation of the brain as a functional network in which the connections between brain regions are represented by correlation values across time series has been very popular in the last years. Although this representation has…

机器学习 · 计算机科学 2021-09-28 Ahmed El-Gazzar , Rajat Mani Thomas , Guido van Wingen

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

神经元与认知 · 定量生物学 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

A thorough understanding of the neuroanatomy of peripheral nerves is required for a better insight into their function and the development of neuromodulation tools and strategies. In biophysical modeling, it is commonly assumed that the…

Multivariate regression models for age estimation are a powerful tool for assessing abnormal brain morphology associated to neuropathology. Age prediction models are built on cohorts of healthy subjects and are built to reflect normal aging…

计算机视觉与模式识别 · 计算机科学 2018-04-05 Benjamin Gutierrez Becker , Tassilo Klein , Christian Wachinger

It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the…

神经元与认知 · 定量生物学 2024-11-01 Hina Shaheen , Roderick Melnik

We propose a curve-based Riemannian-geometric approach for general shape-based statistical analyses of tumors obtained from radiologic images. A key component of the framework is a suitable metric that (1) enables comparisons of tumor…

应用统计 · 统计学 2017-02-07 Karthik Bharath , Sebastian Kurtek , Arvind Rao , Veerabhadran Baladandayuthapani

Human brain networks can be characterized at different temporal or spatial scales given by the age of the subject or the spatial resolution of the neuroimaging method. Integration of data across scales can only be successful if the combined…

Brain aging is a widely studied longitudinal process throughout which the brain undergoes considerable morphological changes and various machine learning approaches have been proposed to analyze it. Within this context, brain age prediction…

计算机视觉与模式识别 · 计算机科学 2020-11-30 Matthias Wilms , Jordan J. Bannister , Pauline Mouches , M. Ethan MacDonald , Deepthi Rajashekar , Sönke Langner , Nils D. Forkert

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

神经元与认知 · 定量生物学 2023-08-24 Yihan Wu , Lana Vasung , Camilo Calixto , Ali Gholipour , Davood Karimi

We propose a mesh-based technique to aid in the classification of Alzheimer's disease dementia (ADD) using mesh representations of the cortex and subcortical structures. Deep learning methods for classification tasks that utilize structural…

图像与视频处理 · 电气工程与系统科学 2022-03-14 Emanuel A. Azcona , Pierre Besson , Yunan Wu , Arjun Punjabi , Adam Martersteck , Amil Dravid , Todd B. Parrish , S. Kathleen Bandt , Aggelos K. Katsaggelos