相关论文: Vocal markers from sustained phonation in Huntingt…
Huntington disease (HD) is a fatal autosomal dominant neurocognitive disorder that causes cognitive disturbances, neuropsychiatric symptoms, and impaired motor abilities (e.g., gait, speech, voice). Due to its progressive nature, HD…
Speech is a critical biomarker for Huntington Disease (HD), with changes in speech increasing in severity as the disease progresses. Speech analyses are currently conducted using either transcriptions created manually by trained…
Objective: This study aimed to evaluate which voice features can predict health deterioration in patients with chronic HF. Background: Heart failure (HF) is a chronic condition with progressive deterioration and acute decompensations, often…
Parkinson's disease (PD) is a chronic neurodegenerative disease. Early diagnosis is essential to mitigate the progressive deterioration of patients' quality of life. The most characteristic motor symptoms are very mild in the early stages,…
Background: Huntington's disease (HD) is a rare, genetically determined brain disorder that limits the life of the patient, although early prognosis of HD can substantially improve the patient's quality of life. Current HD prognosis methods…
One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches…
As one of the most prevalent neurodegenerative disorders, Parkinson's disease (PD) has a significant impact on the fine motor skills of patients. The complex interplay of different articulators during speech production and realization of…
Parkinson's disease (PD) is a progressive neurodegenerative disorder that, in addition to directly impairing functional mobility, is frequently associated with vocal impairments such as hypophonia and dysarthria, which typically manifest in…
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including altered voice production in the early stages. Early diagnosis is crucial not only to improve PD patients' quality of life but also to…
Parkinson's disease is a progressive neurodegenerative disorder affecting motor and non-motor functions, with speech impairments among its earliest symptoms. Speech impairments offer a valuable diagnostic opportunity, with machine learning…
Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by…
Voice disorders significantly affect communication and quality of life, requiring an early and accurate diagnosis. Traditional methods like laryngoscopy are invasive, subjective, and often inaccessible. This research proposes a noninvasive,…
Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detection have shown strong performance, their interpretability remains underexplored. This study…
Hypernasality is a common characteristic symptom across many motor-speech disorders. For voiced sounds, hypernasality introduces an additional resonance in the lower frequencies and, for unvoiced sounds, there is reduced articulatory…
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbances, and cognitive decline. The onset of HD is marked by severe motor impairment, which may be predicted…
Huntington Disease (HD) is a progressive disorder which often manifests in motor impairment. Motor severity (captured via motor score) is a key component in assessing overall HD severity. However, motor score evaluation involves in-clinic…
Longitudinal voice biomarkers provide a non-invasive source of information for monitoring Parkinson's disease progression, but their statistical analysis is difficult because repeated measurements from the same subject are correlated,…
In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a…
Parkinson's disease is a neurodegenerative disorder that can be very tricky to diagnose and treat. Such early symptoms can include tremors, wheezy breathing, and changes in voice quality as critical indicators of neural damage. Notably,…
Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…