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Thalamic alterations are relevant to many neurological disorders including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Routine interventions to improve symptom severity in movement disorders, for example, often consist…

计算机视觉与模式识别 · 计算机科学 2018-07-31 Veronica Corona , Jan Lellmann , Peter Nestor , Carola-Bibiane Schoenlieb , Julio Acosta-Cabronero

This work explored an element-wise approach to model transcranial MRI-guided focused ultrasound (TcMRgFUS) thermal ablation, a noninvasive approach to neurosurgery. Each element of the phased array transducer was simulated individually and…

医学物理 · 物理学 2020-01-01 Nathan McDannold , P. Jason White , Rees Cosgrove

The thalamus is a subcortical gray matter structure that plays a key role in relaying sensory and motor signals within the brain. Its nuclei can atrophy or otherwise be affected by neurological disease and injuries including mild traumatic…

图像与视频处理 · 电气工程与系统科学 2023-02-02 Chang Yan , Muhan Shao , Zhangxing Bian , Anqi Feng , Yuan Xue , Jiachen Zhuo , Rao P. Gullapalli , Aaron Carass , Jerry L. Prince

Purpose: To adjust the location of the ablation focus by correcting the spatial discrepancy induced by temperature changes between the target coordinate and the hotspot as seen in MR thermography. Methods: A two-step correction procedure…

医学物理 · 物理学 2025-01-03 Chang-Sheng Mei , Shenyan Zong , Bruno Madore , Garth R. Cosgrove , Nathan J. McDannold

Transcranial MRI-guided focused ultrasound (TcMRgFUS) thermal ablation is a noninvasive functional neurosurgery technique. Previous reports have shown that bone marrow damage in the skull can occur at high acoustic energies. While this…

医学物理 · 物理学 2019-12-03 Nathan McDannold , P. Jason White , Rees Cosgrove

The thalamus is a subcortical structure of central importance to brain function, which is organized in smaller nuclei with specialized roles. Despite significant functional and clinical relevance, locating and distinguishing the different…

The thalamus and its constituent nuclei are critical for a broad range of cognitive and sensorimotor processes, and implicated in many neurological and neurodegenerative conditions. However, the functional involvement and specificity of…

图像与视频处理 · 电气工程与系统科学 2023-09-27 Brendan Williams , Dan Nguyen , Julie Vidal , Alzheimer's Disease Neuroimaging Initiative , Manojkumar Saranathan

Deep Brain Stimulation (DBS) is one of the most successful methods to diminish late-stage Parkinson's Disease (PD) symptoms. It is a delicate surgical procedure which requires detailed pre-surgical patient's study. High-field Magnetic…

图像与视频处理 · 电气工程与系统科学 2024-07-23 Tomás Lima , Igor Varga , Eduard Bakštein , Daniel Novák , Victor Alves

Accurate segmentation of thalamic nuclei is important for better understanding brain function and improving disease treatment. Traditional segmentation methods often rely on a single T1-weighted image, which has limited contrast in the…

图像与视频处理 · 电气工程与系统科学 2024-09-12 Anqi Feng , Zhangxing Bian , Blake E. Dewey , Alexa Gail Colinco , Jiachen Zhuo , Jerry L. Prince

While diffusion MRI has been extremely promising in the study of MTBI, identifying patients with recent MTBI remains a challenge. The literature is mixed with regard to localizing injury in these patients, however, gray matter such as the…

计算机视觉与模式识别 · 计算机科学 2017-08-31 Shervin Minaee , Yao Wang , Sohae Chung , Xiuyuan Wang , Els Fieremans , Steven Flanagan , Joseph Rath , Yvonne W. Lui

The human thalamus is a brain structure that comprises numerous, highly specific nuclei. Since these nuclei are known to have different functions and to be connected to different areas of the cerebral cortex, it is of great interest for the…

Intracorporeal needle-based therapeutic ultrasound (NBTU) is a minimally invasive option for intervening in malignant brain tumors, commonly used in thermal ablation procedures. This technique is suitable for both primary and metastatic…

Accurate neuronavigation is essential for generating the intended effect with transcranial magnetic stimulation (TMS). Precise coil placement also directly influences stimulation efficacy. Traditional neuronavigation systems often rely on…

人机交互 · 计算机科学 2026-01-29 Xuyi Hu , Ke Ma , Siwei Liu , Per Ola Kristensson , Stephan Goetz

Accurate segmentation of thalamic nuclei from magnetic resonance images is important due to the distinct roles of these nuclei in overall brain function and to their differential involvement in neurological and psychiatric disorders.…

图像与视频处理 · 电气工程与系统科学 2025-12-08 Anqi Feng , Zhangxing Bian , Samuel W. Remedios , Savannah P. Hays , Blake E. Dewey , Alexa Colinco , Jiachen Zhuo , Dan Benjamini , Jerry L. Prince

Foot temperature profiling is of utmost importance is mitigating the adverse effects due to foot complications especially due to diabetes. Contactless temperature monitoring methods could be used effectively in large scale for patient…

High Intensity Focused Ultrasound (HIFU) is a promising therapy for thermal ablation and hyperthermia, characterised by it noninvasiveness, high penetration depth. Effective HIFU thermo-therapy requires the ability to accurately predict…

医学物理 · 物理学 2020-07-14 Gajendra Singh , Anup Paul , Himanshu Shekhar , Abhijit Paul

Hyperthermia (HT) in combination with radio- and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures between 39 and 43 $^\circ$C for 60…

Transient brain-wide neuroimaging on a microscopic scale is pivotal for brain research, yet current modalities face challenges in meeting such spatiotemporal requirements. Functional ultrasound (fUS) enables transient neurovascular imaging…

医学物理 · 物理学 2025-12-09 Yang Cai , Shaoyuan Yan , Long Xu , Yanfeng Zhu , Bo Li , Kailiang Xu

Accurate neuronavigation is critical for effective transcranial magnetic stimulation (TMS), as stimulation outcomes depend directly on precise coil placement. Existing neuronavigation systems are often costly, complex, and prone to tracking…

人机交互 · 计算机科学 2026-01-26 Xuyi Hu , Ke Ma , Siwei Liu , Per Ola Kristensson , Stefan Goetz

Intraoperative ultrasound imaging is used to facilitate safe brain tumour resection. However, due to challenges with image interpretation and the physical scanning, this tool has yet to achieve widespread adoption in neurosurgery. In this…

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