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The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development,…

定量方法 · 定量生物学 2025-12-10 Xiao Yuan

Algorithmic decision support is rapidly becoming a staple of personalized medicine, especially for high-stakes recommendations in which access to certain information can drastically alter the course of treatment, and thus, patient outcome;…

计算机视觉与模式识别 · 计算机科学 2021-08-16 Haomin Chen , T. Y. Alvin Liu , Catalina Gomez , Zelia Correa , Mathias Unberath

Explainable AI (XAI) methods generally fall into two categories. Post-hoc approaches generate explanations for pre-trained models and are compatible with various neural network architectures. These methods often use feature importance…

计算机视觉与模式识别 · 计算机科学 2025-05-20 Piotr Borycki , Magdalena Trędowicz , Szymon Janusz , Jacek Tabor , Przemysław Spurek , Arkadiusz Lewicki , Łukasz Struski

Explainable AI (XAI) in medical histopathology is essential for enhancing the interpretability and clinical trustworthiness of deep learning models in cancer diagnosis. However, the black-box nature of these models often limits their…

图像与视频处理 · 电气工程与系统科学 2025-05-06 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H. Graham , Lois Browne , Arcot Sowmya , Erik Meijering

The deployment of Machine Learning models intraoperatively for tissue characterisation can assist decision making and guide safe tumour resections. For image classification models, pixel attribution methods are popular to infer…

计算机视觉与模式识别 · 计算机科学 2025-08-01 Alfie Roddan , Chi Xu , Serine Ajlouni , Irini Kakaletri , Patra Charalampaki , Stamatia Giannarou

Large Multimodal Models (LMMs), or Vision-Language Models (VLMs), have shown impressive capabilities in a wide range of visual tasks. However, they often struggle with fine-grained visual reasoning, failing to identify domain-specific…

计算机视觉与模式识别 · 计算机科学 2025-02-26 Yucheng Shi , Quanzheng Li , Jin Sun , Xiang Li , Ninghao Liu

As lung cancer evolves, the presence of enlarged and potentially malignant lymph nodes must be assessed to properly estimate disease progression and select the best treatment strategy. Following the clinical guidelines, estimation of…

图像与视频处理 · 电气工程与系统科学 2022-05-03 David Bouget , André Pedersen , Johanna Vanel , Haakon O. Leira , Thomas Langø

Deep learning has demonstrated expert-level performance in melanoma classification, positioning it as a powerful tool in clinical dermatology. However, model opacity and the lack of interpretability remain critical barriers to clinical…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Junwen Zheng , Xinran Xu , Li Rong Wang , Chang Cai , Lucinda Siyun Tan , Dingyuan Wang , Hong Liang Tey , Xiuyi Fan

Algorithmic approaches to interpreting machine learning models have proliferated in recent years. We carry out human subject tests that are the first of their kind to isolate the effect of algorithmic explanations on a key aspect of model…

计算与语言 · 计算机科学 2020-05-06 Peter Hase , Mohit Bansal

LIME (Local Interpretable Model-agnostic Explanations) is a popular XAI framework for unraveling decision-making processes in vision machine-learning models. The technique utilizes image segmentation methods to identify fixed regions for…

计算机视觉与模式识别 · 计算机科学 2025-09-22 Patrick Knab , Sascha Marton , Christian Bartelt

In recent years, there has been a significant surge in malware attacks, necessitating more advanced preventive measures and remedial strategies. While several successful AI-based malware classification approaches exist categorized into…

密码学与安全 · 计算机科学 2024-04-22 Quincy Card , Daniel Simpson , Kshitiz Aryal , Maanak Gupta , Sheikh Rabiul Islam

We introduce a method, KL-LIME, for explaining predictions of Bayesian predictive models by projecting the information in the predictive distribution locally to a simpler, interpretable explanation model. The proposed approach combines the…

机器学习 · 计算机科学 2018-10-08 Tomi Peltola

With an increase in deep learning-based methods, the call for explainability of such methods grows, especially in high-stakes decision making areas such as medical image analysis. This survey presents an overview of eXplainable Artificial…

图像与视频处理 · 电气工程与系统科学 2022-05-06 Bas H. M. van der Velden , Hugo J. Kuijf , Kenneth G. A. Gilhuijs , Max A. Viergever

Live-cell imaging of multiple subcellular structures is essential for understanding subcellular dynamics. However, the conventional multi-color sequential fluorescence microscopy suffers from significant imaging delays and limited number of…

亚细胞过程 · 定量生物学 2025-01-13 Mingyang Chen , Luhong Jin , Xuwei Xuan , Defu Yang , Yun Cheng , Ju Zhang

Explainable Deep Learning has gained significant attention in the field of artificial intelligence (AI), particularly in domains such as medical imaging, where accurate and interpretable machine learning models are crucial for effective…

图像与视频处理 · 电气工程与系统科学 2024-09-11 Subhashis Suara , Aayush Jha , Pratik Sinha , Arif Ahmed Sekh

Machine learning applied to generate data-driven models are lacking of transparency leading the process engineer to lose confidence in relying on the model predictions to optimize his industrial process. Bringing processes in the industry…

机器学习 · 计算机科学 2020-07-21 Cedric Schockaert , Vadim Macher , Alexander Schmitz

Protein language models (PLMs) have revolutionised computational biology through their ability to generate powerful sequence representations for diverse prediction tasks. However, their black-box nature limits biological interpretation and…

生物大分子 · 定量生物学 2025-04-11 Jan van Eck , Dea Gogishvili , Wilson Silva , Sanne Abeln

Pathologists have a rich vocabulary with which they can describe all the nuances of cellular morphology. In their world, there is a natural pairing of images and words. Recent advances demonstrate that machine learning models can now be…

机器学习 · 计算机科学 2022-07-14 Simon M. Thomas , James G. Lefevre , Glenn Baxter , Nicholas A. Hamilton

Recent developments in Artificial Intelligence (AI) and their applications in critical industries such as healthcare, fin-tech and cybersecurity have led to a surge in research in explainability in AI. Innovative research methods are being…

人工智能 · 计算机科学 2025-08-26 Aoun E Muhammad , Kin-Choong Yow , Nebojsa Bacanin-Dzakula , Muhammad Attique Khan

Effective AI governance requires structured approaches for stakeholders to access and verify AI system behavior. With the rise of large language models, Natural Language Explanations (NLEs) are now key to articulating model behavior, which…

计算与语言 · 计算机科学 2025-07-16 Isar Nejadgholi , Mona Omidyeganeh , Marc-Antoine Drouin , Jonathan Boisvert