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Large language models (LLMs) have shown various ability on natural language processing, including problems about causality. It is not intuitive for LLMs to command causality, since pretrained models usually work on statistical associations,…

计算与语言 · 计算机科学 2024-08-27 Chenyang Zhang , Haibo Tong , Bin Zhang , Dongyu Zhang

Causal inference is central to many areas of artificial intelligence, including complex reasoning, planning, knowledge-base construction, robotics, explanation, and fairness. An active community of researchers develops and enhances…

人工智能 · 计算机科学 2019-11-05 Amanda Gentzel , Dan Garant , David Jensen

With advanced imaging, sequencing, and profiling technologies, multiple omics data become increasingly available and hold promises for many healthcare applications such as cancer diagnosis and treatment. Multimodal learning for integrative…

基因组学 · 定量生物学 2022-12-20 Sina Tabakhi , Mohammod Naimul Islam Suvon , Pegah Ahadian , Haiping Lu

Consciousness spans macroscopic experience and microscopic neuronal activity, yet linking these scales remains challenging. Prevailing theories, such as Integrated Information Theory, focus on a single scale, overlooking how causal power…

神经元与认知 · 定量生物学 2025-09-16 Zhipeng Wang , Yingqi Rong , Kaiwei Liu , Mingzhe Yang , Jiang Zhang , Jing He

Large language models (LLMs) are trained on enormous amounts of data and encode knowledge in their parameters. We propose a pipeline to elicit causal relationships from LLMs. Specifically, (i) we sample many documents from LLMs on a given…

机器学习 · 计算机科学 2026-03-05 Takashi Kameyama , Masahiro Kato , Yasuko Hio , Yasushi Takano , Naoto Minakawa

Hybrid models composing mechanistic ODE-based dynamics with flexible and expressive neural network components have grown rapidly in popularity, especially in scientific domains where such ODE-based modeling offers important interpretability…

机器学习 · 计算机科学 2026-02-02 Bob Junyi Zou , Matthew E. Levine , Dessi P. Zaharieva , Ramesh Johari , Emily B. Fox

Estimating the causal effect of an exposure on an outcome is an important task in many economical and biological studies. Mendelian randomization, in particular, uses genetic variants as instruments to estimate causal effects in…

统计方法学 · 统计学 2017-06-06 Sai Li

In this paper, the relationship between probabilistic graphical models, in particular Bayesian networks, and causal diagrams, also called structural causal models, is studied. Structural causal models are deterministic models, based on…

人工智能 · 计算机科学 2026-04-24 Peter J. F. Lucas , Eleonora Zullo , Fabio Stella

Deep Learning models have shown success in a large variety of tasks by extracting correlation patterns from high-dimensional data but still struggle when generalizing out of their initial distribution. As causal engines aim to learn…

机器学习 · 计算机科学 2024-01-02 Gaël Gendron , Michael Witbrock , Gillian Dobbie

Medical image analysis is a vibrant research area that offers doctors and medical practitioners invaluable insight and the ability to accurately diagnose and monitor disease. Machine learning provides an additional boost for this area.…

计算机视觉与模式识别 · 计算机科学 2022-11-29 Athanasios Vlontzos , Daniel Rueckert , Bernhard Kainz

The ability to robustly identify causal relationships is essential for autonomous decision-making and adaptation to novel scenarios. However, accurately inferring causal structure requires integrating both world knowledge and abstract…

机器学习 · 计算机科学 2025-06-17 Khurram Yamin , Shantanu Gupta , Gaurav R. Ghosal , Zachary C. Lipton , Bryan Wilder

Causal dynamics models (CDMs) have demonstrated significant potential in addressing various challenges in reinforcement learning. To learn CDMs, recent studies have performed causal discovery to capture the causal dependencies among…

机器学习 · 计算机科学 2024-05-22 Zhongwei Yu , Jingqing Ruan , Dengpeng Xing

Computational analysis of time-course data with an underlying causal structure is needed in a variety of domains, including neural spike trains, stock price movements, and gene expression levels. However, it can be challenging to determine…

人工智能 · 计算机科学 2012-05-14 Samantha Kleinberg , Bud Mishra

We introduce computational causal inference as an interdisciplinary field across causal inference, algorithms design and numerical computing. The field aims to develop software specializing in causal inference that can analyze massive…

统计计算 · 统计学 2020-07-22 Jeffrey C. Wong

One of the basic aims in science is to unravel the chain of cause and effect of particular systems. Especially for large systems this can be a daunting task. Detailed interventional and randomized data sampling approaches can be used to…

统计方法学 · 统计学 2016-11-30 Seyed Mahdi Mahmoudi , Ernst Wit

The continuing advances of omic technologies mean that it is now more tangible to measure the numerous features collectively reflecting the molecular properties of a sample. When multiple omic methods are used, statistical and computational…

基因组学 · 定量生物学 2023-08-14 Tim Downing , Nicos Angelopoulos

While probabilistic models describe the dependence structure between observed variables, causal models go one step further: they predict, for example, how cognitive functions are affected by external interventions that perturb neuronal…

神经元与认知 · 定量生物学 2021-04-12 Sebastian Weichwald , Jonas Peters

Emergence and causality are two fundamental concepts for understanding complex systems. They are interconnected. On one hand, emergence refers to the phenomenon where macroscopic properties cannot be solely attributed to the cause of…

物理与社会 · 物理学 2024-02-27 Bing Yuan , Zhang Jiang , Aobo Lyu , Jiayun Wu , Zhipeng Wang , Mingzhe Yang , Kaiwei Liu , Muyun Mou , Peng Cui

In this paper we review important aspects of semiparametric theory and empirical processes that arise in causal inference problems. We begin with a brief introduction to the general problem of causal inference, and go on to discuss…

统计理论 · 数学 2016-07-25 Edward H. Kennedy

The use of genetic variants as instrumental variables - an approach known as Mendelian randomization - is a popular epidemiological method for estimating the causal effect of an exposure (phenotype, biomarker, risk factor) on a disease or…

统计方法学 · 统计学 2020-12-21 Ioan Gabriel Bucur , Tom Claassen , Tom Heskes